The purpose of this review is to explain the function of LL-37 in the pathogenesis of chronic sinusitis. LL-37 is the only human cathelicidin identified so far. LL-37 is an integral part of the innate immune,the role of which in chronic sinusitis is attracting more and more s attention.
Cathelicidins ; metabolism ; Chronic Disease ; Humans ; Sinusitis ; immunology ; metabolism ; pathology

Objective To investigate researches on magnet hospital and nursing management from January 1,2010 to December 31,2014 in PubMed database and provide reference information for the majority of professionals in deep research.Methods Bibliographies from research literature of magnet hospital and nursing management from January 1,2010 to December 31,2014 in PubMed database were downloaded.The publication years,journals,countries of publication,the high yielding first authors and the high frequency of main subject were counted by Bicomb 2.0 software.The affiliations were analyzed artificially.main subject appeared no less than two times were intercepted as high frequency ones and the high frequency main subject co-occurrence matrix were formed.SPSS20.0 statistical software were applied for clustering analysis with matrix,then to get the topic hotspots.Results A total of 62 literatures were screened out.The data of research trend,journals,research degree of countries were acquired.The number of high frequency main subject were 18 and among which 4 research hotspots were clustered,respectively workplace environment and job satisfaction,nursing education,nursing quality administration,creation and leadership.Conclusions Researches on magnet hospital and nursing management from January 1,2010 to December 31,2014 in PubMed database are mainly in terms of workplace environment and job satisfaction,nursing education,nursing quality administration,creation and leadership.They are the foundation of the current research situation and trend of magnet hospital nursing management,and can improve management efficiency and provide reference for scientific research topic selection project.

Obejective To analyze the related papers on nursing competency in China from 2004 to2014,and to learn the current status and developing trends of nursing competency,so as to provide reference for further research and development of nursing competency.Methods All literature related to nursing competency from 2004 to 2014 were searched in the China National Knowledge Infrastructure(CNKI),VIP Database for Chinese Technical Periodicals (VIP),and Wanfang database.Bibliometric analysis methods were used to analyze the distribution time,area,journal distribution and research categories by using Microsoft Excel.Results Totally 199 articles related to nursing competency were collected and the number of publications increased in recent years.About 78.89％ (157/199) papers were published in the statistical source journal and 34.17％ (68/199) papers were focused on survey research about nursing competency.Conclusions Nursing competency have been paid more attention to,but the quality of the literature still need to be improved.

Since the transcranial magnetic stimulation (TMS) is a non-invasive technique to interfere neu-ral activity of brain, the combination of TMS and other neuron-imaging techniques has been widely used, espe-cially in cognitive research. Electroencephalogram (EEG) occupies a special position in this field due to its higher time resolution and lower experimental cost. The present paper reviews the application of TMS-EEG combined technique from the aspects of the main research topics, simultaneous recording, artifacts elimination, data pro-cessing and so on. Current problems and possible solution related to this technique are also discussed in the pa-per. With those new related solutions being put forward, more achievements will be obtained in the research area of TMS-EEG combined technique.

Objective To investigate the charge nurses' leadership style perceived by nurses and nurse's self-efficacy,and then analyze the relationship between them.Methods Totally 368 staff nurses from 3A hospitals in Sichuan were investigated with questionnaires.The results underwent analysis.Results The score of charge nurses' transformational leadership style was 58.06±12.10,from high to low in turn was intellectual stimulation (3.10±0.69),inspirational motivation (2.92±0.73),idealized influence (2.88±0.67) and individualized consideration (2.71±0.74).The score of charge nurses' transactional leadership style was 35.77±8.58,from high to low in turn was contingency reward (3.11±0.71),passive exemplary management (3.09±0.75) and active exemplary management (2.75±0.90).The score of nurses' self-efficacy was 83.51±11.62.The transformational leadership style had positively predictive impact on nurses' selfefficacy.Conclusions Nursing managers should apply transformational leadership to improve nurses selfefficacy,promote the physical and mental health of nurses and the long-term development of hospital.

Objective To investigate the nurses′tasks in community hospitals in southwest China, so as to provide references for building nursing profession advanced examination system matching with the clinical requirements of community. Methods Different Professional Titles Nurses′ Tasks Questionnaire developed by the Ministry of Health was used to investigate 201 nurses in 10 community hospitals that were randomly selected in southwest China. Results Nurse professional title with primary title mainly accounted for 59.20% (119/201),and the nurses who had received secondary and college degree accounted for 43.28%(87/201), 38.81%(78/201). 120 items of nursing tasks were divided into 8 dimensions, the highest of implementation frequency score was the dimension related with drug treatment which scored 3.05±1.18, while the lowest was related with meeting the patients′basic needs which scored 1.40 ± 1.05; the highest of tasks′ importance assess score was the task dimension related with drug treatment which scored 3.36 ± 0.56, while the lowest was the dimension of communications which scored 2.74 ± 0.81. The correlation analysis of execution frequency and importance assess of each dimension showed a significant positive correlation (r=0.161-0.397,P<0.05), except the dimension related with drug treatment(r=0.128,P>0.05). Score difference of tasks’execution frequency and importance evaluation for different Professional titles nurses had no statistical significance (P>0.05). Conclusions The reform of the nurses′career advanced examination should be combined with development status and nurses′tasks in community, in addition, both raising the nurses′ comprehensive quality and improving job responsibilities and functions division of community is the basis of the reform.

This article described how simulation is used at Loma Linda University Medical Simulation Center.Detail description and examples were provided to help medical educators undemmnd the method of using the virtual simulator for teaching fast and efficient decision making skills at a high level of interactive medical education.

Objective To analyze the trend of nursing information system(Nursing Information System,NIS) and contemporary situation,so as to provide a reference for the further development of NIS in China.Methods Based on China Academic Journal Network Publishing Database,Wanfang database and VIP Chinese academic periodical database,retrieval published NIS literature from 2009 to 2013 in China.Seven aspects were analyzed:time,areal distribution,cooperative rate,authors,institutions,periodicals and keywords.Results There were 438 articles from 128 published journals,47.9％ papers were in the statistical source journals.Research content mainly involved clinical nursing and nursing management.Conclusions NIS research has achieved great development in the past 5 years,but the researches should be strengthened in breadth and depth.

Objective To determine the inhibitory effect of the synthetic Nrf 2 siRNA on the expression of Nrf2 gene in human laryngeal cancer cell lines Hep2 and to investigate the effects of Nrf2 siRNA on chemosensitivity of laryngeal carcinoma to cisplatin by detection growth and apoptosis in Hep2 cells .Methods The recombinant plas‐mid control siRNA and Nrf2 siRNA were transfected into Hep2 cells ,and western blot analysis of Nrf2 expression in Hep2 cells was performed 48 h after transfection .In order to determine whether Nrf2 siRNA can enhance the sensi‐tivity of Hep2 laryngeal cells to cisplatin ,we treated Hep2 cells with different concentrations of cisplatin after 24 h , and evaluated these cells for proliferation ,and apoptosis .CCK - 8 and flow cytometry assay were used for determi‐nation of cells proliferation and apoptosis in Hep2 cells .We calculated the inhibition rate and IC50 of the cell after treating with different concentrations of ciplatin .Results The laryngeal carcinoma cell stain Hep2 was transfected by Nrf2 siRNA and control siRNA respectively .The result of western blot showed the Nrf 2 expression was signifi‐cantly impeded at protein levels .CCK - 8 assay showed the proliferation of Hep2/Nrf2 siRNA and Hep2/ control siRNA was inhibited to 35 .55% to 46 .07% at 24 h respectively after treating with 4 μg/ml cisplatin .The chemo‐sensitivity to cisplatin in Hep2/Nrf2 siRNA was markly increased compared with Hep2/control siRNA .The IC50 in Hep2/Nrf2 siRNA was 5 .27 μg/ml contrast to 8 .107 μg /ml compared in Hep2/control siRNA .The result of flow cytometry analysis showed the apoptosis rate after Nrf 2 depletion was increased from 17 .1% to 26 .6% .Conclusion This study demonstrates that Nrf2 siRNA effectively inhibits Nrf2 gene expression in Hep2 cells leading to growth suppression and induction of apoptosis in Hep2 cells under cisplatin .The use of siRNA technique may pro‐vide a novel therapeutic approach to treat laryngeal cancer for enhance chemosensitivity .

Objective To understand status quo of the domestic and foreign iceberg competency model application,and to provide basis for further study in the nursing iceberg competency model.Methods A literature review about the application of competency iceberg model at home and abroad since 2009 was carried out,the relevant data was listed,and the research situation of domestic and foreign nursing iceberg competency model was summarized.Results According to the 141 total literatures whose theme was the iceberg competency model,only 3 articles were related to the nursing field,while most of the iceberg competency model aimed at the study of enterprises in the high-level management personnel,sales personnel and so on.More researches on competency iceberg model were conducted abroad,involved in all walks of life,an research direction of nursing had turned from general iceberg competency model to the study of specific posts.Conclusions The iceberg competency model applied to the management of nursing human resources in China is developed lately and the studies lack breadth,depth and scientificalness.Compared with foreign countries,there is a big gap.A thorough iceberg competency model for human resource management is ought to be studied to provide a new perspective and a more useful tool for the early Chinese nursing theory and practice.