Diabetic dry eye is a prevalent ocular surface disease and has a profound impact on patients'quality of visual acuity.The pathological changes of diabetic dry eye are influenced by a multitude of factors,involving the effects of hyperglycemia on the ocular surface microenvironment and corneal nerves,oxidative stress and the accumulative effect of glycation end products.Current therapeutic strategies include physiotherapy,tear replacement therapy,promotion of ocu-lar surface repair,and anti-inflammatory therapy.However,these treatments have certain limitations.This article presents a summary of the research conducted on the pathogenesis and clinical treatment of diabetic dry eye in recent years,aiming to provide clinicians with new ideas for developing personalized treatment plans for diabetic dry eye patients.

Diabetes mellitus(DM)is a chronic metabolic disease characterized by persistent hyperglycemia and rapidly increasing. The ocular surface microbiota(OSM)consists of microbial communities that colonize the eye surface, mainly bacteria, and perform an important role in maintaining ocular health. Hyperglycemia creates a favorable microenvironment for the OSM, leading to an imbalance of the microflora. However, unpredictable changes in OSM are strongly associated with dry eye disease, corneal neuropathy, and infectious ocular surface diseases in environmental changes. In recent years, next-generation sequencing technology has been applied to detect the OSM and confirm that the eye microbiome is closely related to DM. Research indicates that dysbiosis of the OSM plays a critical role in the onset and progression of DM-related ocular surface diseases. This review investigates the correlation between OSM and patients with DM. Moreover, we provide a reference for the occurrence and development of diabetes-related ocular surface diseases and their treatment.