Objective:To investigate the correlation between the change of color vision and anxiety or depression in patients with Parkinson's disease (PD). Methods:From November, 2018 to November, 2019, 63 PD patients from the PD database of Department of Neurology, Dalian Friendship Hospital were selected, and they were tested with Farnsworth-Munsell 100 Hue Test (FMT), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS) and Hospital Anxiety and Depression Scale (HADS). Their age, gender, course of disease, education level, Hoehn-Yahr (H-Y) stage, Unified Parkinson's Disease Rating Scale part III (UPDRSIII), levodopa dose, and scores of Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were collected as related factors, and anlyzed with correlation analysis and multivariate regression. Results:The score of FMT was correlated with the scores of HAMA, SAS, HAMD, SDS, and both HADS anxiety and depression (r > 0.561,P < 0.001). Age, H-Y stage, course of disease, score of UPDRSIII, levodopa dose and scores of MMSE and MoCA were related with the score of FMT independently. Conclusion:Color vision dysfunction in PD patients is correlated to the severity of anxiety and depression, and it is affected with age, severity of PD and cognitive impairment.

OBJECTIVE: To explore the relationship among character strength,life stress events and emotional well-being in nursing staffs. METHODS: A total of 2 160 nursing staffs in 8 grade 3 A Hospitals in Liaoning Province were selected as study subjects by cluster random sampling method. The Chinese version of General Information Questionnaire of Character Strengths Scale,Life Event Scale,Emotional Well-Being Scale were used to explore the character strength,life stress events and emotional well-being in these nursing staffs,as well as the mediating effect of character strength in life stress events and emotional well-being. RESULTS: The total score of character strength was( 42. 59 ± 5. 78),the total score of life stress events was( 139. 32 ± 3. 26),and that of emotional well-being was( 23. 26 ± 5. 18). The total score of life stress events was negatively correlated with emotional well-being score [correlation cofficient( r) =-0. 382,P < 0. 01 ],the total score of character strength was positively correlated with emotional well-being( r = 0. 453,P < 0. 01). The mediating effect of character strength in life stress events and emotional well-being was-0. 332,accounting for 50. 84% of the total effect. CONCLUSION: The life stress events in nursing staffs can negatively predict their emotional well-being. The character strength plays a mediating role affecting the life stress events and the emotional well-being.

Objective To observe the effect of marrow mesenchymal stem cells(MSCs)transplantation combined with Qidantongmai tablet and simple MSCs transplantation on myocardial cells apoptosis and heart function in acute myocardial ischemia rats.Method Rat MSCs were isolated by density gradient method,and then cultured and amplified to the third passage labeled with BrdU.16 SD rats were divided into two groups randomly,transplantation combined with Qidantongmai tablet group and simple transplantation group.The isochoric of suspension of Qidantongmai tablet(2 g/kg)and NS were administered to SD rats by gastrogavage respectively for 14 days.The left anterior descending coronary artery of rat was ligated to establish animal models of acute myocardial infarction.The MSCs labeled with BrdU were implanted intramyocardially into the infarct area.After 3 hours,the heart function were detected by an echocardiographic system(HP 5500 system),equipped with a 12 MHz probe.After 4 weeks,the heart function were rechecked and MVD were detected by immunofluorescence,myocardial cells apoptosis were detected by TUNNEL.Results Heart function were improved in both groups,and was more significant in MSCs transplantation combined with Qidantongmai tablet group.Apoptotic index were decreased and the MVD of ischemic zone were increased in transplantation combined with Qidantongmai tablet group than simple transplantation group.Conclusion MSCs transplantation combined with Qidantongmai tablet could improve heart function of acute myocardial ischemia rats,decrease apoptosis of myocardial cells,increase the MVD of ischemic zone,the therapeutic effect were more significant than simple MSCs transplantation.

AIM: To explore the changes of related proteins of neural stem cell differentiation and proliferation in rats treated with corticosterone (CORT). METHODS: Western blot method was used to investigate the changes of related protein of neural stem cell differentiation and proliferation. RESULTS: Compared with the normal control group, related proteins (Notch1, hes5, Mash1 and NeuroD) of neural stem cell differentiation and proliferation were significantly decreased in the CORT rats on the day 30 and 60, especially for Mash1 and NeuroD (P

This paper introduces the structure and main features of TMS320VC5416, the 16-bit fixed-point DSP of TI company. It discusses the principle and scheme of the adaptive filter using LMS and FX-LMS algorithm to distill voice form noises and to cancel noises with this kind of DSP. It also describes the problems during the process of designing the hardware and software.

Objective To establish rat models with Sporadic Alzheimer’s disease(SAD) induced by intracerebroventricular administration of streptozotocin(ic-STZ),and observe the effects of compound Jinsiwei(GETO) on learning and memorizing ability of rats.Methods To establish the Sporadic Alzheimer’s disease model by intracerebroventricular micro-injection of STZ bilaterally.GETO groups were treated with gastric perfusion of GETO in three different dosage for 3 months.Learning and memorizing ability of the rats were inspected through Morris water maze test.The effects of GETO and Donepezil were observed and compared.Results In place navigation test,the escape latency and swimming distance were significantly longer in the model group than that in the sham group(P

OBJECTIVE: To explore the effect of premenstrual syndrome( PMS) on the quality of life( QOL) of female medical staffs. METHODS: By convenient sampling method,1 007 female medical workers from three Grade A class 3 hospitals were selected as study subjects and investigated by PMS Scale,World Health Organization Quality of Life Assessment Instrument Brief Version,Simplified Coping Style Questionnaire and Social Support Rating Scale. RESULTS: The detection rate of PMS among medical staffs was 52. 0%,and the total score of QOL of PMS medical staffs was lower than that of non-PMS medical staffs [( 84. 3 ± 12. 4) vs( 90. 5 ± 11. 6),P < 0. 01]. The multivariate linear logistic regression analysis results showed that the PMS medical staffs who often stay up late,with higher degree of dysmenorrhea,higher job stress,lower positive coping style score,higher negative coping style score,and poor support have lower QOL( P < 0. 05). The coping style and social support of PMS medical staffs can directly affect the QOL. The social support can also indirectly affect the QOL through coping style. CONCLUSION: Coping style is a mediator of social support and QOL.Adopting coping style can improve the QOL of PMS medical staffs.

OBJECTIVE: To explore the relationship among occupational stress,job satisfaction and psychological capital in oil workers,to analyze the role of psychological capital in mediating occupational stress and job satisfaction. METHODS: By cluster random sampling method,1 837 oil workers in western Liaoning area were chosen as study subjects. The EffortReward Imbalance,Minnesota Satisfaction Questionnaire and Psy Cap Questionnaire( PCQ-24) were used to investigate their occupational stress, job satisfaction and psychological capital. RESULTS: The average score of oil workers in occupational stress was( 66. 17 ± 6. 78),and the score of job satisfaction was( 68. 13 ± 14. 03),the score of psychological capital was( 96. 65 ± 20. 36). Internal investment,return on dimension of occupational stress and psychological capital and job satisfaction was positively correlated [the correlation coefficient( r) was 0. 09,0. 25,0. 62,respectively,P <0. 05]. The external dimensions and job satisfaction was negatively correlated( r =- 0. 27,P < 0. 05). Occupational stress and psychological capital had direct prediction on job satisfaction( P < 0. 05). Psychological capital on the mediation effect of occupational stress and job satisfaction was 0. 34,29. 11 % of the total effect. CONCLUSION: Occupational stress and job satisfaction was partially mediated by psychological capital. Adjusting the psychological capital can reduce the occupational stress and affect job satisfaction of oil workers.

Objective To investigate the effect of Fingomod（FTY720）on the cerebral ischemia-reperfusion injury in rats. Methods SPF rats（250 g～300 g）of 8 weeks old were divided into sham operation group，blank control group，group of Clopidogrel and group of FTY720.Rat model of ischemic stroke was made by tMCAO. The behavioral disorder scores were scored in different groups after different drug treatments. And observing the area of infarctus tissue by the TTC method and the nerve cells changed by HE method in different groups. The levels of inflammatory factors IL-1β and IL-6 in brain tissue of rats were changed by method of ELISA. The level of p-p38MAPK and NF-κB in brain tissue of rats were determined by Western-blot method. Results（1）FTY720 can alleviate the behavior disorder of rats（P<0.01）；（2）FTY720 can reduce the area of infarctus tissue（P<0.01）and the injury of neurology cells in rats；（3）FTY720 can reduce the level of p-p38MAPK and NF-κB（P<0.01）in the ischemic brain tissue of rats；4，FTY720 can be reduced The level of IL-1β（P<0.01）and IL-6（P<0.01）in the ischemic brain tissue. Conclusion Fingomod（FTY720）has a protective effect on the cerebral ischemia-reperfusion rat model by decreasing the level of inflammatory response.

Objective To evaluate the effect of sodium-dependent glucose transporters 2(SGLT-2)inhibitors on carotid artery elasticity in patients with diabetes mellitus type 2 by applying the ultrafast pulse wave velocity(UFPWV).Methods A total of 82 patients with diabetes mellitus type 2 admitted to the First Affiliated Hospital of Jinzhou Medical University from January to June 2022 were selected and randomly divided into control group(n=41)and observation group(n=41),and both groups were treated with conventional hypoglycemic therapy,and patients in observation group were combined with the treatment of SGLT-2 inhibitor on the basis of control group,and the patients of both groups were treated for 1 year.Systolic blood pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI),fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c),carotid intima-media thickness(CIMT),and UFPWV technique was used to measure the common carotid artery pulse wave velocity-beginning of systole(PWV-BS)and pulse wave velocity-end of systole(PWV-ES).Results ①The comparison between SBP,DBP,BMI,FPG,2h PG,HbA1c,CIMT,PWV-BS,PWV-ES indexes of the two groups of patients before treatment,the difference was not significant(P>0.05);② After receiving treatment,SBP,DBP,BMI,FPG,2hPG,HbA1c,CIMT,PWV-BS,PWV-ES of patients in observation group were lower than those of control group before treatment,and the differences were statistically significant(P<0.05);③ FPG,2hPG,HbA1c,SBP,DBP,BMI,CIMT,PWV-BS,PWV-ES indexes of observation group were lower than those of control group after treatment,and the difference was statistically significant(P<0.05).Conclusion UFPWV can effectively assess the value of SGLT-2 inhibitors in improving carotid artery elasticity in patients with diabetes mellitus type 2 with high accuracy and simplicity.