1.Clinical characteristics, diagnosis and treatment of Castleman's disease
Xibo FU ; Jinyun HE ; Hai SHANG
Cancer Research and Clinic 2010;22(10):716-718
Castleman's disease is a rare disorder of the lymphoid system characterized by noncancerous growths that may develop in lymph node tissues throughout the body. The incidence of this disease has been increasing in recent years. Because of the difficulty of diagnosis and high-misdiagnosis, more and more clinicians have paid close attention to this disease. By the clinical work, and with the help of related reports, the preliminary summary of this disease is made.
2.Searching of medical English teaching in physical medical physicians training
Xuemei HE ; Xiaojuan JI ; Jinyun CHEN ; Yan WANG ; Jianzhong ZOU
Chinese Journal of Medical Education Research 2011;10(3):362-364
Requirement for Medical English teaching in physical medicine physicians training has been on the agenda to fit the new condition of globalization. According to the development of physical medicine in China and students English level, courses of medical English were set to match the requirements of both scientific research and clinic works. We try to improve students' medical English level through lectures in multimedia classroom and a lot of practical activities after class.
3.Application of oral administration of mannitol and intramuscular injection of anisodamine in magnetic resonance enteroclysis
Xiaoying PENG ; Jinyun HE ; Zhi LIN ; Zhuhao LI ; Xun ZENG ; Shiting FENG ; Xiyun SHE
Modern Clinical Nursing 2014;(10):29-31
ObjectiveTo study the effects of oral administration of mannitol and intramuscular injection of anisodamine in magnetic resonance enteroclysis.Methods After complete intestinal cleaning,29 patients undergoing magnetic resonance enteroclysis were orally administered with 5% oral isotonic mannitol solution 2000 mL and treated with intramuscular injection of anisodamine before the operation.The adverse reactions were observed,the image quality was inspected and the dilatation of small bowel was detected.Results All of the patients lived through the magnetic resonance enteroclysis.Two patients contracted Crohn’s disease with mild nausea consciousness.Conclusion For magnetic resonance imaging,preoperative oral administration of 2.5% oral isotonic mannitol solution and intramuscular injection of anisodamine after complete intestinal cleaning is beneficial for fully expanding the small intestine,achieving quality imaging and therefore improving the diagnosis of small intestinal lesions.
4.Application of small intestine double stoma and succus entericus reinfusion in the patients with severe intra-abdominal infection.
Jinguo ZHU ; Jian WANG ; Yuan HE ; Haiwen ZHUANG ; Jinyun YANG
Chinese Journal of Gastrointestinal Surgery 2015;18(7):667-670
OBJECTIVETo evaluate the application of small intestine double stoma and succus entericus reinfusion in the patients with severe intra-abdominal infection.
METHODSTen patients with high intestinal perforation from February 2005 to November 2014 were enrolled in the study. All the cases received emergency operation. Small bowel with intestinal perforation was resected, and double stoma was applied in the proximal and distal small intestine. When abdominal infection under control, total enteral nutrition was successfully administered from nasogastric tube. The succus entericus from the proximal intestine was collected and transfused back to the distal intestine. Stool was collected and fecal nitrogen, fat and carbohydrate contents were determined. Related serum protein levels were measured.
RESULTSAs compared to pre-reinfusion, the absorption rate of carbohydrate [(90.9±7.8)% vs. (82.7±15.2)%], fat [(87.6±6.4)% vs. (59.1±10.8)%], and nitrogen [(82.4±9.8)% vs. (67.2±15.4)%] increased after succus entericus reinfusion (P<0.05). The serum protein levels increased significantly as well[fibronectin: (285.6±3.6) vs. (157.0±22.6) mg/L, P<0.01; transferrin: (4.86±0.21) vs. (3.60±0.25) g/L, P<0.05; pre-albumin: (291.3±112.5) vs. (199.1±53.3) mg/L, P<0.05].
CONCLUSIONSmall intestine double stoma and succus entericus reinfusion are effective in improving the absorption of carbohydrate, fat and nitrogen in the patients with severe intra-abdominal infection.
Enteral Nutrition ; Humans ; Intestinal Perforation ; Intestinal Secretions ; Intestine, Small ; Intraabdominal Infections ; Surgical Stomas
5.A study on the present situation and influencing factors of outpatient nurses'caring behavior
Xiyun SHE ; Jinyun HE ; Xun ZENG
Modern Clinical Nursing 2023;22(10):24-29
Objective To investigate caring behavior and empathy ability of outpatient nurses and analyse the correlation between them,and explore the influencing factors of caring behavior,then to provide basis for the management of outpatient nurses.Methods Convenience sampling method was employed to enroll 335 outpatient nurses from class 3 Grade A hospitals in Guangdong Province from February to April 2023 as research subjects.Surveys were conducted with general information questionnaire,caring behaviors inventory and the Jefferson scale of empathy-health professionals.Pearson correlation was used to analyze the correlation between caring behavior and empathy ability of outpatient nurses,and multiple regression was used to analyze the influencing factors of caring behavior.Results A total of 307 outpatient nurses completed the study.The total score of caring behavior of outpatient nurses was(5.14±0.72)points and the scores of each dimension were opinion selection,perspective-taking and emotional care from high to low.The total score of empathy ability of outpatient nurses was(5.81±0.66)points,and was at a high level,and the scores of each dimension were opinion selection,perspective-taking and emotional care from high to low.Pearson correlation analysis showed that the total score of caring behavior and scores of each dimension of outpatient nurses were positively correlated with the total score of empathy ability and scores of each dimension(all P<0.01).Multiple linear regression analysis showed that opinion selection was an independent factor affecting the caring behavior of outpatient nurses(P<0.01).Conclusions The caring behavior and empathic ability of outpatient nurses are both at a high level,and their caring behavior is related to their empathic ability.The empathy ability of outpatient nurses is the key to affect their caring behavior.Hospital managers should teach outpatient nurses to consider problems from the standpoint of patients and give humanistic care to patients,so as to improve outpatient'medical experience and improve outpatients'satisfaction.
6.Exploratory study on noninvasive evaluation of renal histopathology by ultrasonic shear wave elastography
Jinyun PU ; Lei YE ; Yonghua HE ; Rongrong XU ; Siying YANG ; Huiqing YUAN ; Siyuan LIU ; Wenpei LIANG ; Liru QIU
Chinese Journal of Nephrology 2023;39(8):587-594
Objective:To determine a relationship between ultrasound shear wave elastography (SWE) and pathological lessions of renal tissues in children with chronic kidney disease (CKD).Methods:It was a cross-sectional observational study, involving children admitted to the Department of Pediatrics of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from January to December 2021 with definite pathological diagnosis through kidney biopsy. The SWE was used to determine the Young's modulus (elastic modulus) of the cortex and medulla of the upper, middle, and lower poles of the kidney. The renal histopathology was classified or graded. The statistical method was used to analyze the relationship between Young's modulus of the inferior polar cortex (YM cor) and medulla (YM med) of the right kidney and renal pathology. Results:The study included 110 children with definite pathological diagnosis through renal biopsy, aged (10.1±3.4) years old (2-17 years old), with 55 males (50.0%). The body mass index was (20.6±2.4) kg/m 2, and mean arterial pressure was (95±24) mmHg. There were 94 patients (85.4%) with CKD stage 1, 8 patients (7.3%) with CKD stage 2, and 8 patients (7.3%) with CKD stage 3. There was no significant difference of YM cor and YM med in the upper and middle poles of the right kidneys, and YM med in the lower poles of right kidneys in CKD patients with different stages (all P>0.05). Both YM cor [(15.75±3.36) kPa] and YM med [(13.50±2.43) kPa] of CKD stage 3 patients were significantly higher than those of CKD stage 1 patients [(12.94±2.45) kPa, (11.88±2.23) kPa](both P<0.05). There was no significant difference of YM cor and YM med in the lower poles of right kidneys between stage 1 and stage 2 CKD patients (both P>0.05). YM cor[(17.93±3.23) kPa] and YM med [(15.50±1.48) kPa] in patients with crescentic glomerulonephritis were higher than those in patients with focal segmental glomerulosclerosis [(12.71±2.42) kPa, (11.57±2.63) kPa] and mesangial proliferative glomerulonephritis [(12.73±2.04) kPa, (11.48±2.10) kPa](all P<0.05). There was no significant difference of YM cor and YM med between focal segmental glomerulosclerosis and mesangial proliferative glomerulonephritis (both P>0.05). YM cor [(16.30±2.63) kPa] and YM med [(15.54±1.59) kPa] of Lee's Ⅳ grade of IgA nephropathy were higher than those of Lee's Ⅲ grade [(13.32±2.70) kPa, (12.57±2.50) kPa](both P<0.05), while the International Study of Kidney Disease in Children grade of purpura nephritis had no significant correlation with YM cor and YM med (both P>0.05). YM cor [(15.41±2.37) kPa] and YM med [(13.82±2.59) kPa] of interstitial fibrosis/tubular atrophy (T1/T2) group of IgA nephropathy mixed with purpura nephritis were significantly higher than those of T0 group's [(12.99±2.40) kPa, (11.79±2.05) kPa] (both P<0.05). Moreover, crescent formation (C1) group had a higher YM cor [(14.21±2.77) kPa] and YM med [(12.80±2.47) kPa] than those in C0 group [(12.73±2.15) kPa, (11.59±1.97) kPa] (both P<0.05), while YM cor and YM med were unrelated to the mesangial hypercellularity (M), endocapillary cellularity (E), segmental sclerosis or adhesion (S) indicators (all P>0.05). In lupus nephritis patients, YM cor ( r=0.744, P=0.035) and YM med ( r=0.728, P=0.009) were favorably linked with the chronic index, but not with the activity index (both P>0.05). Conclusions:Renal interstitial fibrosis/tubular atrophy and crescentic development are connected with YM cor and YM med at the lower pole of the kidney as measured by SWE. SWE can be used to assess the chronic renal lesions in children with CKD in the early and middle stages. It may develop into a new noninvasive way to assess renal pathology.
7.The radionuclide imaging and therapy for metastatic prostate cancer
Xuexin HE ; Jinyun ZHOU ; Haoran LI ; Chentao JIN ; Mei TIAN
Chinese Journal of Urology 2021;42(10):792-796
Metastatic prostate cancer is one of the most malignancies and do harm to the health and life expectancy of men. The popularization and application of 68Gallium or 18Fluorine labeled prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) benefit for the excellent diagnostic efficacy, unique value in the diagnosis of metastatic prostate cancer, clinical decision-making guidance, efficacy in monitoring and prognosis evaluation. 223Radium and 177Lu-PSMA radioligand therapy (RLT) could effectively alleviate bone pain, and prolong the overall survival time (OS) as wellas progression-free survival time (PFS) with good safety. In addition, survival of patients with metastatic prostate cancer is expected to be further improved with the advance in the combination therapies with PSMA RLT, androgen-deprivation therapy (ADT), chemotherapy, targeted therapy and immunotherapy.
8.Shoot rot of Zizania latifolia and the first record of its pathogen Pantoea ananatis in China.
Zilan XIAO ; Jianping DENG ; Xiaojun ZHOU ; Liyan ZHU ; Xiaochan HE ; Jingwu ZHENG ; Deping GUO ; Jingze ZHANG
Journal of Zhejiang University. Science. B 2022;23(4):328-338
The aquatic grass Zizania latifolia grows symbiotically with the fungus Ustilago esculenta producing swollen structures called Jiaobai, widely cultivated in China. A new disease of Z. latifolia was found in Zhejiang Province, China. Initial lesions appeared on the leaf sheaths or sometimes on the leaves near the leaf sheaths. The lesions extended along the axis of the leaf shoots and formed long brown to dark brown streaks from the leaf sheath to the leaf, causing sheath rot and death of entire leaves on young plants. The pathogen was isolated and identified as the bacterium Pantoea ananatis, based on 16S ribosomal RNA (rRNA) gene sequencing, multilocus sequence analysis (atpD (β-subunit of ATP synthase F1), gyrB (DNA gyrase subunit B), infB (translation initiation factor 2), and rpoB (β-subunit of RNA polymerase) genes), and pathogenicity tests. Ultrastructural observations using scanning electron microscopy revealed that the bacterial cells colonized the vascular tissues in leaf sheaths, forming biofilms on the inner surface of vessel walls, and extended between vessel elements via the perforated plates. To achieve efficient detection and diagnosis of P. ananatis, species-specific primer pairs were designed and validated by testing closely related and unrelated species and diseased tissues of Z. latifolia. This is the first report of bacterial sheath rot disease of Z. latifolia caused by P. ananatis in China.
Pantoea/genetics*
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Plant Diseases/microbiology*
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Poaceae/microbiology*
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Virulence
9. Structural, Functional, and Molecular Imaging of Autism Spectrum Disorder
Xiaoyi LI ; Xiao HE ; Jinyun ZHOU ; Chentao JIN ; Yuanxue GAO ; Mei TIAN ; Hong ZHANG ; Xiaoyi LI ; Xiao HE ; Jinyun ZHOU ; Chentao JIN ; Yuanxue GAO ; Mei TIAN ; Hong ZHANG ; Hong ZHANG ; Kai ZHANG ; Lesang SHEN ; Xiaoyi LI ; Xiao HE ; Jinyun ZHOU ; Chentao JIN ; Yuanxue GAO ; Mei TIAN ; Hong ZHANG ; Hong ZHANG
Neuroscience Bulletin 2021;37(7):1051-1071
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder associated with both genetic and environmental risks. Neuroimaging approaches have been widely employed to parse the neurophysiological mechanisms underlying ASD, and provide critical insights into the anatomical, functional, and neurochemical changes. We reviewed recent advances in neuroimaging studies that focused on ASD by using magnetic resonance imaging (MRI), positron emission tomography (PET), or single-positron emission tomography (SPECT). Longitudinal structural MRI has delineated an abnormal developmental trajectory of ASD that is associated with cascading neurobiological processes, and functional MRI has pointed to disrupted functional neural networks. Meanwhile, PET and SPECT imaging have revealed that metabolic and neurotransmitter abnormalities may contribute to shaping the aberrant neural circuits of ASD. Future large-scale, multi-center, multimodal investigations are essential to elucidate the neurophysiological underpinnings of ASD, and facilitate the development of novel diagnostic biomarkers and better-targeted therapy.
10.Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor cells in rats with cerebral ischemia.
Yao YAO ; Rui ZHOU ; Rui BAI ; Jing WANG ; Mengjiao TU ; Jingjing SHI ; Xiao HE ; Jinyun ZHOU ; Liu FENG ; Yuanxue GAO ; Fahuan SONG ; Feng LAN ; Xingguo LIU ; Mei TIAN ; Hong ZHANG
Frontiers of Medicine 2021;15(3):472-485
Hypoxia conditioning could increase the survival of transplanted neuronal progenitor cells (NPCs) in rats with cerebral ischemia but could also hinder neuronal differentiation partly by suppressing mitochondrial metabolism. In this work, the mitochondrial metabolism of hypoxia-conditioned NPCs (hcNPCs) was upregulated via the additional administration of resveratrol, an herbal compound, to resolve the limitation of hypoxia conditioning on neuronal differentiation. Resveratrol was first applied during the in vitro neuronal differentiation of hcNPCs and concurrently promoted the differentiation, synaptogenesis, and functional development of neurons derived from hcNPCs and restored the mitochondrial metabolism. Furthermore, this herbal compound was used as an adjuvant during hcNPC transplantation in a photothrombotic stroke rat model. Resveratrol promoted neuronal differentiation and increased the long-term survival of transplanted hcNPCs. 18-fluorine fluorodeoxyglucose positron emission tomography and rotarod test showed that resveratrol and hcNPC transplantation synergistically improved the neurological and metabolic recovery of stroke rats. In conclusion, resveratrol promoted the neuronal differentiation and therapeutic efficiency of hcNPCs in stroke rats via restoring mitochondrial metabolism. This work suggested a novel approach to promote the clinical translation of NPC transplantation therapy.
Animals
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Brain Ischemia/drug therapy*
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Cell Differentiation
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Hypoxia
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Neurons
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Rats
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Resveratrol/pharmacology*