1.Incidentally Detected Hypopharyngeal Mass during Endotracheal Intubation
Ana CHO ; Jinyoung SO ; Eun Young KO ; Dasom CHOI
Soonchunhyang Medical Science 2020;26(1):45-47
Hypopharyngeal mass is an uncommon condition in the aerodigestive tract. There were only a few cases have been published in the medical literature. We experienced a case of incidentally detected hypopharyngeal mass during endotracheal intubation. Hypopharyngeal mass was located at the right posterior pharyngeal wall. The hypopharyngeal mass was small and not obstruct the glottis, and endotracheal intubation was performed successfully. We have also briefly discussed symptoms, diagnosis, and related problems during general anesthesia of hypopharyngeal mass.
2.A Case of Plasmodium malariae Infection Imported from Guinea.
Yun Jung KANG ; Moon Jung SHIM ; Jung Yeon KIM ; So Young JI ; Won Ja LEE ; Jinyoung YANG
Laboratory Medicine Online 2015;5(1):33-37
Recently, the number of Korean travelers and workers to malaria-endemic regions has increased, and the number of patients with imported malaria cases has increased as well. In Korea, most cases of imported malaria infections are caused by Plasmodium falciparum and P. vivax. Only one report of imported P. malariae infection has been published thus far. Here, we describe a case of imported P. malariae infection that was confirmed by peripheral blood smear and nested PCR targeting the small subunit ribosomal RNA (SSU rRNA) gene. A 53-yr-old man, who had stayed in the Republic of Guinea in tropical West Africa for about 40 days, experienced fever and headache for 3 days before admission. The results of rapid malaria test using the SD Malaria Antigen/Antibody Kit (Standard Diagnostics, Korea) were negative, but Wright-Giemsa stained peripheral blood smear revealed Plasmodium. To identify the Plasmodium species and to examine if the patient had a mixed infection, we performed nested PCR targeting the SSU rRNA gene. P. malariae single infection was confirmed by nested PCR. Sequence analysis of the SSU rRNA gene of P. malariae showed that the isolated P. malariae was P. malariae type 2. Thus, our findings suggest that when cases of imported malaria infection are suspected, infection with P. malariae as well as P. falciparum and P. vivax should be considered. For the accurate diagnosis and treatment of imported malaria cases, we should confirm infection with Plasmodium species by PCR as well as peripheral blood smear and rapid malaria antigen test.
Africa, Western
;
Coinfection
;
Diagnosis
;
Fever
;
Genes, rRNA
;
Guinea*
;
Headache
;
Humans
;
Korea
;
Malaria
;
Plasmodium
;
Plasmodium falciparum
;
Plasmodium malariae*
;
Polymerase Chain Reaction
;
RNA, Ribosomal
;
Sequence Analysis
3.Squamous Cell Carcinoma Developed in Nevus Sebaceus: A Case Report.
Hyun Joo CHOI ; Jinyoung YOO ; Lee So MAENG ; Seok Jin KANG ; Chang Suk KANG
Korean Journal of Pathology 2004;38(1):60-63
We report a case of squamous cell carcinoma developed within the nevus sebaceus (NS) and review the literature. An 82-year-old woman presented with a 3-month history of pain within the lifelong skin lesion on her right cheek. Examination revealed a 1.0 x 1.0 cm poorly marginated, slightly raised yellow-brown nodule. Microscopically, the skin nodule revealed the typical findings of NS. Squamous cell carcinoma developed contiguously within the keratin-filled infundibulocyst of NS disconnected from the epidermis. We suggest that squamous cell carcinoma is derived from the embryonal stratum germinativum de-differentiated from the primary epithelial germ cells in the infundibulocyst of NS. Most secondary carcinomas associated with NS grow slowly over a period of years. In contrast, squamous cell carcinoma developed in NS often grow rapidly with aggressive behavior. Thus, the accurate pathologic diagnosis is necessary.
Aged, 80 and over
;
Carcinoma, Squamous Cell*
;
Cheek
;
Diagnosis
;
Epidermis
;
Female
;
Germ Cells
;
Humans
;
Nevus*
;
Skin
4.The Risk of Microalbuminuria by Obesity Phenotypes according to Metabolic Health and Obesity: The Korean National Health and Nutrition Examination Survey 2011–2014.
Inyoung CHOI ; Heesun MOON ; So Young KANG ; Hyeonyoung KO ; Jinyoung SHIN ; Jungkwon LEE
Korean Journal of Family Medicine 2018;39(3):168-173
BACKGROUND: The present study aimed at identifying the difference in the risk of microalbuminuria among individuals with various obesity phenotypes in terms of metabolic health and obesity. METHODS: This cross-sectional study included 15,268 individuals and used data from the National Health and Nutrition Survey conducted from 2011 to 2014. Obesity was defined as body mass index ≥25 kg/m2. Metabolically unhealthy was defined as meeting two or more of the following criteria: systolic and diastolic blood pressure ≥130/85 mm Hg or current use of hypertensive drugs; triglyceride level ≥150 mg/dL; high-density lipoprotein level < 40/50 mg/dL (in both men and women); and fasting blood glucose level ≥100 mg/dL or current use of oral antidiabetic medications. The participants were further classified into four subgroups: metabolically healthy non-obese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy non-obese (MUNO), and metabolically unhealthy obese (MUO). RESULTS: A significant difference was observed in the microalbuminuria ratio among the four groups. The MHNO group was considered as the reference group, and the MHO, MUNO, and MUO groups were at an increased risk for microalbuminuria by 1.42 fold (95% confidence interval [95% CI], 1.03–1.96), 2.02 fold (95% CI, 1.61–2.53), and 3.40 fold (95% CI, 2.70–4.26), respectively, after adjusting confounding factors. CONCLUSION: The MUNO group had a higher risk of developing microalbuminuria than the MHNO group. Thus, based on this result, differences were observed in the risk of developing microalbuminuria among individuals with various obesity subtypes.
Albuminuria
;
Blood Glucose
;
Blood Pressure
;
Body Mass Index
;
Creatinine
;
Cross-Sectional Studies
;
Fasting
;
Humans
;
Lipoproteins
;
Male
;
Metabolic Diseases
;
Nutrition Surveys*
;
Obesity*
;
Phenotype*
;
Triglycerides
5.IgG4-Related Lung Disease without Elevation of Serum IgG4 Level: A Case Report.
Min Kyu KANG ; Yongseon CHO ; Minsoo HAN ; Sun Young JUNG ; Kyoung Min MOON ; Jinyoung KIM ; Ju Ri KIM ; Dong Kyu LEE ; Jun Hyung PARK ; So Hee CHUNG
Tuberculosis and Respiratory Diseases 2016;79(3):184-187
Since IgG4-related pancreatitis was first reported in 2001, IgG4-related disease has been identified in other organs such as salivary gland, gallbladder, thyroid, retroperitoneum and kidney; but lung invasion is rare. A 63-year-old man presented with hemoptysis at the pulmonary clinic and chest computed tomography revealed about 4.1 cm irregular shaped mass with spiculated margin at the left upper lobe. Despite no elevation of serum IgG4 level, he was finally diagnosed as IgG4-related lung disease by transthoracic needle biopsy. After treatment with oral glucocorticoids, hemoptysis disappeared and the size of lung mass was decreased.
Biopsy, Needle
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Gallbladder
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Glucocorticoids
;
Hemoptysis
;
Humans
;
Immunoglobulin G*
;
Immunoglobulins
;
Kidney
;
Lung Diseases*
;
Lung*
;
Middle Aged
;
Pancreatitis
;
Salivary Glands
;
Thorax
;
Thyroid Gland
6.Pulmonary Cryptococcosis Mimicking Primary Lung Cancer with Multiple Lung Metastases.
Yu Seung KIM ; In Hee LEE ; Hyun Seon KIM ; Su Sin JIN ; Jong Hwan LEE ; Sung Kyoung KIM ; So Hyang SONG ; Jinyoung YOO ; Chi Hong KIM ; Soon Seog KWON
Tuberculosis and Respiratory Diseases 2012;73(3):182-186
Cryptococcosis is an invasive fungal infection, which is more common in immunocompromised patients. However, pulmonary cryptococcosis can occur in immunocompetent patients and should be considered on a differential diagnosis for nodular or mass-like lesions in chest radiograph. Recently, we experienced a patient with pulmonary cryptococcosis, successfully treated with oral fluconazole therapy. A 74-year-old female patient was referred for an evaluation of abnormal images, a large consolidative mass with multiple nodular consolidations and small nodules that mimics primary lung cancer with multiple lung to lung metastases. Computed tomography-guided lung biopsy confirmed the diagnosis of pulmonary cryptococcosis. The follow-up image taken after 4 months with oral fluconazole treatment showed marked improvement.
Aged
;
Biopsy
;
Cryptococcosis
;
Diagnosis, Differential
;
Female
;
Fluconazole
;
Follow-Up Studies
;
Humans
;
Immunocompromised Host
;
Lung
;
Lung Neoplasms
;
Multiple Pulmonary Nodules
;
Neoplasm Metastasis
;
Thorax
7.Kleefstra syndrome combined with vesicoureteral reflux and rectourethral fistula: a case report and literature review
Chae Won LEE ; Min Ji PARK ; Eun Joo LEE ; Sangyoon LEE ; Jinyoung PARK ; Jun Nyung LEE ; So Mi LEE ; Shin Young JEONG ; Min Hyun CHO
Childhood Kidney Diseases 2022;26(2):111-115
Kleefstra syndrome is a rare genetic disease characterized by mental retardation, hypotonia, and a characteristic facial appearance. Furthermore, in some cases, Kleefstra syndrome is associated with various anorectal and genitourinary complications, including imperforated anus, vesicoureteral reflux, hydronephrosis, and chronic kidney disease. Herein, we present a case of Kleefstra syndrome with recurrent urinary tract infections associated with vesicoureteral reflux and rectourethral fistula, which was treated by a multidisciplinary approach.
8.A Rare Case of Hyperfunctioning Lipoadenoma Presenting as a Cystic Pararthyroid Lesion
Jinyoung KIM ; Ohjoon KWON ; Tae-Jung KIM ; So Lyung JUNG ; Eun Ji HAN ; Ki-Ho SONG
Journal of Bone Metabolism 2023;30(2):201-207
A 58-year-old woman visited the hospital complaining of fatigue and indigestion lasting for more than 3 months. She had no medical history other than taking a calcium plus vitamin D supplement for osteopenia. The initial blood test showed a high calcium level of 14.0 mg/dL. Additional tests were performed to differentially diagnose hypercalcemia. The blood test results were as follows: serum parathyroid hormone (PTH)=247.0 pg/mL, PTH-related peptide <1.0 pg/mL, phosphorous=2.6 mg/dL, 25-hydroxy-vitamin D=14.5 pg/mL, creatinine=1.09 mg/dL, and 24 hr urine calcium=215 mg/dL. A 4.5 cm sized cystic lesion on the intra-thyroidal space was confirmed on neck sonography and 4-dimensional parathyroid computed tomography, but technetium-99m methoxyisobutylisonitrile parathyroid scintigraphy showed equivocal results. After removal of the cystic lesion, serum calcium and PTH were normalized, and parathyroid lipoadenoma was confirmed in the postoperative pathology. Clinical features of parathyroid lipoadenoma are known to be similar to common parathyroid adenoma, but imaging studies often report negative findings. Therefore, it is necessary to better understand this rare disease for the differential diagnosis. For the final diagnosis and treatment of this disease, parathyroidectomy with intraoperative PTH measurement may be required.
9.Expression of c-kit and p53 in Non-small Cell Lung Cancers.
Jinyoung YOO ; Chi Hong KIM ; So Hyang SONG ; Byoung Yong SHIM ; Youn Ju JEONG ; Meyung Im AHN ; Sung Whan KIM ; Deog Gon CHO ; Min Seop JO ; Kyu Do CHO ; Hong Joo CHO ; Hoon Kyo KIM
Cancer Research and Treatment 2004;36(3):167-172
PURPOSE: Increasing experimental evidence indicates that abnormal expression of c-kit may be implicated in the pathogenesis of a variety of solid tumors. It has been reported that over 70% of small cell lung cancer (SCLC) contain the c-kit receptor. In the present study, a c-kit analysis has been extended to non-small cell lung cancer (NSCLC). The expressions of p53, vascular endothelial growth factor (VEGF) and cd34, in addition to c-kit, were evaluated to investigate the correlations between these proteins and to determine their potential relationships with the clinicopathological data. MATERIALS AND METHODS: Paraffin-embedded tumor sections, obtained from 147 patients with NSCLC, were immunohistochemically investigated using anti-c-kit, anti- p53, anti-VEGF and anti-cd34 antibodies. RESULTS: c-kit was expressed in 40 (27%) of the tumors examined: 27% of the adenocarcinomas, 27% of the squamous cell carcinomas and 29% of the undifferentiated carcinomas. p53 and VEG F immunoreactivities were present in 107 (73%) and 110 (75%) carcinomas, respectively. Anti-cd34 was negative in all samples. No associations were established among these proteins. The c-kit, however, showed a strong correlation with the T factor: T1 (n=11), 0%; T2 (n=49), 16% and T3 (n=87), 37% (p=.006). CONCLUSION: It is suggested that in NSCLC c-kit is expressed relatively frequently and may become a therapeutic target for the patients with inoperable or recurrent c-kit positive tumors. The alterations in p53 probably constitute an early event, whereas the activated c-kit may contribute to tumor progression.
Adenocarcinoma
;
Antibodies
;
Carcinoma
;
Carcinoma, Non-Small-Cell Lung
;
Carcinoma, Squamous Cell
;
Humans
;
Immunohistochemistry
;
Lung Neoplasms*
;
Lung*
;
Proto-Oncogene Proteins c-kit
;
Small Cell Lung Carcinoma
;
Vascular Endothelial Growth Factor A
10.Expression of Thymidylate Synthase in Non-Small Cell Lung Cancer.
Jinyoung YOO ; Suzi KIM ; Byoung Yong SHIM ; Sung Hwan KIM ; So Hyang SONG ; Deog Gon CHO ; Meyung Im AHN ; Chi Hong KIM ; Kyu Do CHO ; Seok Jin KANG ; Hoon Kyo KIM
Korean Journal of Pathology 2005;39(6):412-417
BACKGROUND: Thymidylate synthase (TS) catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), and this is an essential step in DNA biosynthesis. The present investigation was designed to determine the expression of TS in the patients with non-small cell lung cancer (NSCLC) and to assess the possible associations between the TS status and the p53 or proliferative index (PI). METHODS: The archival tumor tissues from 56 previously untreated NSCLC patients were examined by immunohistochemistry for TS, p53 and Ki-67. RESULTS: Forty-one men and 15 women (age range: 35 to 79 years, mean age: 62 years) were included in this study. The TS expression was high in 40 patients (71.4%) and low in 16 patients (28.6%). The aberrant expression of p53 was detected in 35 patients (62.5%). The mean PI for all the patients was 31.4+/-12.1. The TS-high tumors tended to be more poorly differentiated (p=0.069). The TS expression by a semiquantitative fourscale grading system was significantly correlated with the PIs (p=0.003). No correlation was established between the TS expression and the p53 status (p=0.806) or survival (p=0.951). CONCLUSIONS: TS was not confirmed to be a useful marker for determining the prognosis of NSCLC patients. However, our data suggest that the tumor cells with higher TS expression have a higher proliferative activity.
Carcinoma, Non-Small-Cell Lung*
;
Deoxyuridine
;
DNA
;
Female
;
Humans
;
Immunohistochemistry
;
Lung Neoplasms
;
Male
;
Methylation
;
Prognosis
;
Thymidine
;
Thymidylate Synthase*