1.Effects of preoperative chemotherapy on apoptosis of breast carcinoma at the advanced stage
Yonge OUYANG ; Jianliang ZHUANG ; Jinyang ZHENG ; Rongyu XU ; Wenbin CHEN
Chinese Journal of Clinical and Experimental Pathology 2001;(1):26-27
To determine the effect of pre-operative chemotherapy on apoptosis in breast cancer and to evaluate its signif icance as a prcgnostic marker. MethodsPatients with breast cancer were divided into preoperative chemotherapy group (40 cases)and control group (42 cases). Two groups were analyzed for the appearance of apoptosis by using TUNEL method and electron mi croscope in tissue sections. ResultsApoptosis occurred in 92.5 % of preoperative chemotherapy group and in 78.5 % of control group. The apoptotic indexes were 19.37 + 6.49 and 9.26 + 5.04 ( P < 0.01 ) respectively. Low apoptotic index was related to disease-free survival of patients with breast cancer (P < 0.01 ). ConclusionThe preoperative chemotherapy can induce apoptcsis of breast cancer and improve disease-free survival.
2.Application prospects of trigonelline in regulating metabolic disorders after renal transplantation
Zhongda LI ; Dong LIU ; Xiao WANG ; Jinyang ZHUANG
Organ Transplantation 2021;12(3):363-
Metabolic disorders, such as glucose and lipid, are likely to occur after renal transplantation, leading to graft dysfunction and reduced long-term survival. Trigonelline is a type of natural alkaloid with various biological activities, which can alleviate the metabolic disorders of glucose, lipid and other types, and relieve inflammatory reaction, oxidative stress and cell apoptosis of the kidney, thereby protecting the renal function. Therefore, trigonelline may be a potential drug to regulate metabolic disorders after renal transplantation. In this article, the role of trigonelline in metabolic disorders of glucose, lipid and other types, and its application prospect in renal transplantation were reviewed, aiming to provide reference for alleviating metabolic disorders after renal transplantation and improving the long-term survival of renal transplant recipients and transplanted kidneys.
3.Klotho: a potential protective protein for renal graft
Jinyang ZHUANG ; Dong LIU ; Gengguo DENG ; Xiao WANG
Organ Transplantation 2020;11(4):508-
Klotho gene is an anti-aging gene that is highly expressed in the kidney. Its encoding product Klotho protein can inhibit inflammation, oxidative stress injury, and apoptosis in renal tissue. It is regarded as a renal protective protein and expected to be a new target for the treatment of renal diseases. This article reviewed the biological characteristics of Klotho and the protective effect of Klotho on renal graft function.
4.Application of Mirror Therapy in Rehabilitation for Lower Extremities Motor Function after Stroke (review)
Chinese Journal of Rehabilitation Theory and Practice 2018;24(9):1048-1051
Lower extremities motor dysfunction after stroke severely affects the patients' transfer ability and quality of life. This article reviewed the mirror therapy in rehabilitation of lower extremities motor function in stroke patients.
5. Predictive value of prostate biopsy results based on predictive model established by the PI-RADS version 2
Jinyang LUO ; Jiaxin ZHENG ; Zonglong CAI ; Xiongbo YAO ; Jiaxin CHEN ; Jiecheng ZHANG ; Rui WAN ; Guishuang LIANG ; Jinchun XING ; Xuan ZHUANG
Chinese Journal of Urology 2019;40(9):673-679
Objective:
To explore a predictive nomogram for the result of prostate biopsy based on Prostate Imaging Reporting and Data System version 2(PI-RADS v2)combined with prostate specific antigen (PSA) and its related parameters, and to assess its ability to diagnose prostate cancer by internal validation.
Methods:
We retrospectively analyzed the clinical data of 509 patients who underwent transrectal prostate biopsy guided by ultrasound during the period from January 2014 to December 2018 in the Department of Urology, First Affiliated Hospital of Xiamen University. In 509 cases, the mean age was (68.1±7.2) years. The mean prostate volume(PV) was (55.8±30.7) ml. The mean tPSA value was (19.86±18.94) ng/ml. The mean value of fPSA was (2.63±3.60) ng/ml and the mean f/tPSA was 0.14±0.08. The mean PSAD was (0.46±0.52) ng/ml2. Based on the PI-RADS v2, score 1 point have 37 cases, score 2 point have 131 cases, score 3 point have 152 cases, score 4 point have 102 cases, score 5 point have 87 cases. Of these patients, we randomly selected 80% (407 cases) as development group, and the other 20% (102 cases) as validation group. Univariate and multivariate logistic regression analysis of the development group was performed to identify the independent influence factors that can predict prostate cancer (PCa), thereby establishing a predictive model for the result of prostate biopsy. In the development group, validation group and tPSA was between 4.1-20.0 ng/ml, the model was evaluated by analyzing the receiver operating characteristic (ROC) curve, calibration curve and decision curve, and compared to PSA, fPSA, f/tPSA, PSAD, PI-RADS v2.
Results:
Among the 509 patients enrolled in the study, the detection rate of PCa was 43.0% (219/509). In the development group, the logistic regression analysis demonstrated that patient age (