Objective:To observe the effect of 1 470nm laser anterograde enucleation on benign prostatic hypertrophy (BPH), and its influence on stress response and quality of life.Methods:From July 2018 to May 2019, 90 patients with BPH diagnosed and treated by urology department in Rizhao Central Hospital were selected in the study.According to the different treatment methods, they were divided into two groups, with 45 cases in each group.In the observation group, 1 470nm laser anterograde enucleation of prostate was used.The control group was treated with transurethral plasma resection.The operation time, bladder flushing time, indwelling catheter time and hospitalization time of the two groups were compared.The stress responses of the two groups were compared, including CK, CRP, cortisol and adrenaline levels.The differences of IPSS score, QOL score, maximum urine flow rate (Qmax) and residual urine test (PVR) between the two groups were compared after 6 months of follow-up.The incidence of complications of the two groups was compared.Results:The operation time of the observation group was significantly longer than that of the control group[(80.2±23.5)min vs.(69.5±19.2)min], and the bladder washing time[(1.4±0.3)d vs.(1.7±0.4)d], indwelling catheter time[(5.2±0.9)d vs.(6.2±1.1)d] and hospitalization time[(6.7±1.1)d vs.(8.3±1.6)d] were significantly shorter than those of the control group ( t=4.576, 4.025, 4.719, 5.528, all P<0.05). After operation, the levels of CK[(100.5±11.5)U/L vs.(86.5±9.2)U/L, (103.5±15.4)U/L vs.(87.3±9.9)U/L], CRP[(14.5±2.9)mg/L vs.(12.5±2.5)mg/L, (16.3±3.1)mg/L vs.(12.6±1.9)mg/L], cortisol[(285.2±45.6)ng/mL vs.(235.6±36.5)ng/mL, (310.2±55.6)ng/L vs.(241.6±43.2)ng/L] and adrenaline[(57.8±8.7)pg/mL vs.(51.5±7.8)pg/mL, (62.5±9.9)pg/L vs.(50.9±8.9)pg/L] in the two groups were significantly higher than those before operation ( t=6.377, 6.478, 3.504, 5.125, 5.696, 6.752, 3.617, 4.992, all P<0.05). The levels of CRP, cortisol and adrenaline in the observation group were significantly lower than those in the control group (all P<0.05). After operation, the IPSS score[(7.5±1.6)points vs.(24.2±6.8)points, (7.7±1.9)points vs.(23.8±7.6)points] and QOL score[(1.4±0.5)points vs.(5.0±0.6)points, (1.6±0.6)points vs.(4.9±0.7)points] of the two groups were significantly reduced, Qmax[(21.7±3.5)mL/s vs.(7.5±2.1)mL/s, (22.1±4.3)mL/s vs.(7.8±2.5)mL/s] were significantly increased, PVR[(28.6±7.2)mL vs.(111.2±26.5)mL, (29.3±8.1)mL vs.(114.5±32.5)mL] were significantly increased, the differences were statistically significant ( t=16.037, 14.251, 30.920, 27.528, 23.338, 22.527, 20.178, 21.852, all P<0.05), but there were no statistically significant differences between the two groups (all P>0.05). There was no significant difference in the incidence of postoperative complications between the two groups ( P>0.05). Conclusion:1 470nm laser anterograde enucleation of prostate is a reliable method for the treatment of BPH.

Rheumatoid arthritis is a chronic, systemic autoimmune disease predominantly based on joint lesions with an extremely high disability and deformity rate. Several drugs have been used for the treatment of rheumatoid arthritis, but their use is limited by suboptimal bioavailability, serious adverse effects, and nonnegligible first-pass effects. In contrast, transdermal drug delivery systems (TDDSs) can avoid these drawbacks and improve patient compliance, making them a promising option for the treatment of rheumatoid arthritis (RA). Of course, TDDSs also face unique challenges, as the physiological barrier of the skin makes drug delivery somewhat limited. To overcome this barrier and maximize drug delivery efficiency, TDDSs have evolved in terms of the principle of transdermal facilitation and transdermal facilitation technology, and different generations of TDDSs have been derived, which have significantly improved transdermal efficiency and even achieved individualized controlled drug delivery. In this review, we summarize the different generations of transdermal drug delivery systems, the corresponding transdermal strategies, and their applications in the treatment of RA.