OBJECTIVE One of the objective of the study was to analyze the reliability and validity of the Chinese version of Glasgow children's benefit inventory (GCBI). The other was to explore whether the Chinese version of GCBI could be used as a appropriate evaluation method on children's quality of life (QOL) after tonsillectomy and adenoidectomy (T&A). METHODS Firstly, seventy-three eligible children and their proxies were interviewed with this survey scale, the survey scale was assessed by split-half reliability, internal consistency, content validity and construct validity. Second, the Chinese version of GCBI used to evaluate the changes of these 73 children's QOL at 12 to 18 months after operation. RESULTS First, the reliability coefficient and the construct validity of the Chinese version of GCBI was satisfactory. Second, almost all children's QOL changed better after operation, it improved the most in physical aspects. CONCLUSION The Chinese version of GCBI had good reliability and validity, and is suitable for assessing QOL of children after T&A. It can help clinician evaluate therapeutic effect in pediatric otolaryngology.

Objective: To investigate the rate of post-stroke depression and psychosocial factors related to it, and to provide the direction and the basis for clinical nursing. Methods: 69 patients with stroke were assessed by Zung Self-rating Depression Scale and Type A Behavior Pattern Scale. Their sex, age, behavior type, marital condition, level of education, supportor of medical expenses were collected and analysed statistically. Results: The rate of post-stroke depression was 59.42%, and the rate in type A behavior group was higher than that in the other behavior groups(P

Xuan Fei Run Zao Decoction was used for treatment of 486 cases of psoriasis with a total effective rate of 90. 3%, so as to test and verify the TCM theory of the lung being in charge of the hair and the lung being closely related with derma tosis. Clinical study found that in patients of psoriasis there was humoral immunological hyperfunction, manifesting increases of IgG and IgA; trace elements copper and ferrum levels increased and zinc, manganese and calcium decreased In the hair: packed cell volume and viscosity of whole blood increased, and erythrocyte sedimentation rate increased. It is suggested that psoriasis is possibly related to changes of immunity, blood rheology and trace elements in the body.

Screening of CHD of infants (11 178) born from May 1st 2012 to April 30th 2013.92 infants were screening positive,68 were diagnosed.The detectable rate of CHD was 6.08‰,while boys were 3.31‰,girls were 2.77‰.68 CHD patients,the top three were VSD(2.14‰),PDA(1.34‰) and ASD (0.89‰).In these infants,detectable cardiac souffle were 61,abnormal pulse oximetry were 40.The detectable rate of CHD among infants was identical compare the average level of whole country,but the distributional characteristics was disparity.The screening of CHD was feasible,and cardiac souffle and pulse oximetry were recommended.

Objective To propose A brain computer interface paradigm based on the combination of the motion-onset visual evoked potential(mVEP) and the steady state visual evoked potential(SSVEP).Methods By designing a 3 ×3 character spelling matrix,a vertical white bar in the column of matrix which flicks at a pre-set frequency induced the corresponding SSVEP.The vertical white bar also randomly moved horizontally so as to induce mVEP.Then the two types of features were extracted by time frequency analysis.Finally the support vector machine was applied to compare the target character identification rate between the proposed paradigm and the single mVEP paradigm.Results The target character identification accuracy of subject S1 and S6 was improved by about 2％ comparing the proposed paradigm to the single paradigm.Other subjects achieved the improvement of 6％ for the same performance comparison.The averaged identification accuracy of the proposed paradigm could reach 91.4％ if the same stimulus repeated for more than 3 times,while the accuracy of single paradigm achieved 85.6％.Conclusions The proposed brain computer interface paradigm could effectively induce many kinds of brain feature signals.The identification accuracy by the proposed paradigm is higher than that by the single paradigm for various numbers of repeated trials.The proposed paradigm of combined visual stimulus merges the motion induction and the flash frequency modulation together and hence reduces the stimulation time and increases the efficiency of the feature extraction.

Objective To investigate the role of serum S-100B of umbilical cord blood in the early diagnosis of newborn hypoxic ischemic encephalopathy(HIE).Methotis 307 full-term newborns with asphyxia were selected as subiects and 43 normal full-term newborns delivered during the corresponding period were selected as controls.The umbilical cord blood sample was acquired.46 cases of 307 subjects with asphyxia developed into HIE,31 cases with mild HIE and 15 cases with moderate and severe HIE.The serum S-100B concentration of umbilical cord blood was detected by ELISA analysis.Results ①There was no significant difference in the serum S-100B concentration of umbilical cord blood between the male sub-group and female sub-group in normal group;②The concentration in control group and HIE group were(1.03±0.32)μg/L and(2.53±1.1)μg/L respectively(t=8.848,P＜0.05＝;③The concentration in mild HIE group and moderate to severe HIE group were(1.03±0.32)μg/L nd(3.49±1.23)μg/L respectively,which were significantly different with control group(F=79.6909,P＜0.01).Conclusion Sex has no significant relation to the serum S100B concentration.Serum S-100B concentration of umbilical cord blood can be biomarkers for early diagnosis of newborn HIE.

Objective To establish a system of the screening, evaluation and intervention of congenital heart disease (CHD) in China. Methods All infants (16070) born in Changzhou Maternal and Child Health Hospital from May 1st 2011 to April 30th 2013 were screened for CHD. The infants with CHD were followed up till 1 year of age. Results One hundred and three infants were diagnosed with CHD, and the incidence rate was 0.641%. The top three CHD types in incidences were VSD (0.205%), PDA (0.174%) and ASD (0.10%), respectively. In these infants, 94 cases were followed-up and 9 cases were lost. The incidence of small gapped VSD, ASD and premature PDA were high. Some infants with serious CHD were subjected to surgery, and others were still followed up. Conclusions The incidence of CHD in Changzhou is comparable with that in the whole country. The follow-up can improve the life quality of CHD infants.

Objective To understand the needs of health education of TCM health preservation and re-habilitation in community patients with chronic disease in order to instruct nurses to carry out health education pur-posively. Methods A questionnaire survey was carried out in 320 patients with coronary heart disease, hyper-tension, chronic liver disease, diabetes mellitus, chronic obstructive pulmonary disease(COPD) and other chronic diseases. The investigation contents included cognition of TCM health preservation and rehabilitation, knowledge needs and demand patterns and the results underwent analysis. Results In 320 patients, 11% of patients understood the TCM health preservation and rehabilitation-related knowledge, 43% understood part of it, 46% knew nothing about it. All patients showed different degree of needs for TCM .health preservatiou and reha-bilitatiou and different demand patterns,and the total demand for various educational content was above 90%. Needs for disease prevention, health seasons, TCM dietetic therapy occupied the first three. Health care workers o-ne- to-one education was the most popular form of health education. 75% of the patients hoped that the family members were given health education at the same free. Conclusions Patients with chronic disease possess de-ficient but greater needs for knowledge about TCM health preservation and rehabilitalion. The awareness and ca-pability of serf-care, health preservation and rehabilitation and prevention-tirst should be improved.

The fifth muscarinic receptor (M5), the last one of the mus ca rinic receptor family to be cloned, has the same basic formation characterizatio n as G-protein coupled receptor family. M5 transduces signals by coupling with G-proteins, which then modulate the activities of a number of effector enzymes and ion channels. As M5 also plays a variety of prominent physiological roles by regulating central transmitters NO and DA, it has been considered as a novel dr ug therapy target for drug addiction, dysfunction of dopamine-ergic nervous sys tem, Alzheimers disease and cerebral ischemia.

Objective To discuss the prognostic impact of atrial fibrillation (AF) in patients with chronic heart failure(CHF).Methods From January,2005 through December,2006 we studied 461 patients with a discharge diagnosis of CHF.Patients were divided by baseline rhythm in sinus rhythm(SR) or AF groups.The main endpoints were all cause death within 3 years and readmission to the hospital for heart failure.Results AF group were more likely to be older and female and to have a history of valvular disease and have a higher left ventricular ejection fraction (LVEF).However,SR group were more likely to have a history of ischemic heart disease.During 3 year follow-up,the main endpoints was higher in AF group than in those with SR group (P ＜0.01).After adjusting for other covariables,AF and age were related to increased the risk of main endpoints during 3 years follow-up (RR =1.311,95％ CI:1.002-1.715,P ＜0.05 ; RR =1.014,95％ CI:1.004-1.024,P ＜ 0.01).Conclusion AF and age were the main risk factors of increased adverse forward prognosis in patients with CHF.