Purpose: To observe the clinical effect of combination of acupuncture and Chinese herbal drugs for genual osteoarthritis. Methods: 138 cases of the patients were randomly divided into the treatment group of 85 cases treated by electric acupuncture and moxibustion plus Chinese herbal drugs and the control group of 53 cases treated by oral administration of medications. The patients stopped treatment for one month after the treatment for one month, then the therapeutic effects were observed and compared. Results: The total effective rate was 89.4% in the treatment group and 56.6% in the control group, with extremely significant difference (P ＜ 0.01) between the two groups.Conclusion: Electric acupuncture and moxibustion plus Chinese herbal drugs have a marked and irrefutable therapeutic effect on genual osteoarthritis.