Objective To investigate the status of work-family balance,and explore the relationship between work-family balance and well-being of female prison police.Methods 185 female prison police from one of prison of Sichuan province were assessed using the questionnaires of work-family balance ques tionnaire and well-being scale,and the data were analyzed using t test,one-way ANOVA,pearson correlation analysis and logical multiple linear regression analysis.Results The total score of work-family balance was (10.22± 1.32).The dimension score of work-family balance from high to low were:resource sharing(3.44± 0.60),family balance (3.38±0.53) and work balance (3.12±0.60).There was no remarkable difference on work-family balance between stage of age and family monthly income;but work-family balance declined with the increases of marriageable age and working age (F=13.01,8.25,both P＜ 0.01).Work balance,family balance resource sharing,work-family balance had significant positive correlation with well-being and it's dimensions(r=0.15 ～ 0.60,P＜0.05).Regression analysis showed that age,marriageable age had a negative predic tive effect on job satisfaction and emotion satisfaction(β=-0.20,-0.24,both P＜0.01),and work family balance and it's dimensions had a positive predictive effect on well-being(3=0.282～0.679,P＜0.01).Conclusion Work-family balance has a significant predictive effect on well-being of female prison police.

Objective:To explore improving impact of Sdosodine Hydrochlorida(SBHL) on immune fuction in mice treated with cyclophosphamide(CTX).Methods:BALB/c mice treated with CTX were administrated with SBHL(40 mg/kg) for 7 d.The weights of spleens and thymus of the mice,specific antibody formation of splenocytes,serum agglutinin titer and hemolysin CH50 in mice immunized with SRBC were assayed.The proliferation of mouse splenic lymphocytes actived with ConA were measured.The peritoneal macrophage phagocytosis in mice were analysized.Results:After treatment with SBHL,the indexes of thymus and spleen,and the proliferation of mouse splenic lymphocytes activated with ConA were increased markedly in a dose-dependent manner.The peritoneal macrophage phagocytosis was also improved.Only at the dose of 40 mg/kg were the weights of spleens of mice,specific antibody formation by splenocytes,serum agglutinin titer,hemolysin CH50 of the mice immunized with SRBC increased significantly.Conclusion:SBHL has a remarkable improving effect on the immune functions inhibited by CTX in mice,which may be another important antitumor mechanism of SBHL.

Objective To investigate the perioperative nursing demands of elderly patients receiving laparoscopic cholecystectomy ( LC) . Methods A total of 195 elderly patients receiving LC were interviewed .The nursing care demands at admission, preoperation, postoperation, and discharge were collected respectively . Results On the day of admission, all the 195 patients (100%) wished to be aware of their surgeons , 191 patients ( 97.9%) wished to understand causes of disease and its prevention, 189 patients (96.9%) were willing to know the operation costs , and 124 patients (63.6%) wanted to know the influences of basic diseases on operation.During preoperative periods, 194 patients (98.5%) expected to understand the safety and time of operation, 187 patients (95.9%) were interested in the preparedness before operation , and 135 patients (69.2%) wanted to know about the strategy for treating operation stress .During postoperative periods , 195 patients ( 100%) wanted to know the operation process and outcomes , 185 patients ( 94.9%) wanted necessary cares from nurses , 172 patients ( 88.2%) wanted to know the management for postoperative pain , 148 patients ( 75.9%) expected to understand the drug prescription after operation , and 146 patients (74.9%) were interested in diets and physical activities .At the time of discharge, 195 patients (100%) wanted to be aware of reexamination time and follow-up context, 193 patients (99.0%) wanted to know dietary recommendation , and 177 patients (90.8%) were willing to know the exercise options and time . Conclusion Nurses should be aware of the perioperative care demands in elderly patients receiving LC and provide specific care services to reduce complications and improve rehabilitation .

Objective To revise the American College of Rheumatology classification criteria for rheumatoid arthritis(RA)with anti-cyclic citrullinated peptide(anti-CCP)antibodies and to evaluate its utility in the diagnosis of Chinese patients.Methods All patients from the Department of Rheumatology and Immunology of Peking University People's Hospital who had arthritis complaints in recent two years were enrolled.Patients were divided into RA group and non-RA group according to the clinical diagnosis by experienced rheumatologists.The diagnostic value of ACR criteria and the anti-CCP revised criteria(RA-6,RA-7 and RA-8)were evaluated by analyzing the clinical and laboratory parameters.Results A total of 604 patients were included in the study.312 patients were diagnosed as RA and 292 were diagnosed as other rheumatic diseases by rheumatologists.For those patients who had disease course for less than 2 years,the sensitivity of 1987 ACR criteria,RA-6,RA-7 and RA-8 criteria was 82.0%,91.0%.87.0%and 87.0%,respectively.The specificity of them was 95.6%,83.9%,95.6%and 95.6%.respectively.The sensitivity of 1987 ACR criteria,RA-6,RA-7 and RA-8 criteria for all the RA patients was 92.3%,96.8%.94.6%and 94.6%,respectively.The speciflcity of them was 92.8%,83.6%,92.8%and 92.8%.respectively.Conclusion The 1987 ACR criteria have high sensitivity and specificity in established RA.but its sensitivity in early RA is low.The RA-6criteria can improve the sensitivity dramatically but with reduced specificity.The RA-7 criteria can increase the sensitivity without sacrifice the specificity,especially in early RA patients.It may be used as a new set of classification criteria in clinical practice.

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To explore novel coumarin derivatives with more potent anti-proliferative activity, a series of novel compounds were designed and synthesized by linking Schiff base and N, N-bis (2-chloroethyl) amine pharmacophore of nitrogen mustards to the coumarin's framework. Their structures were confirmed by 1H NMR, MS and element analysis techniques. In vitro anti-proliferative activities were evaluated against HepG2, DU145 and MCF7 cell lines by the standard MTT assay. The results showed that some of the target compounds exhibited strong anti-proliferative activities against selected tumor cells, and compounds 7c, 7f, 7g, 7h and 7q were better than or equal to the activities of positive control, they deserved further development.

Objective To explore the ability of copeptin to predict infarction severity and prognosis after 3 months in patients with acute cerebral infarction .Methods One hundred and thirty‐eight consecutive patients were included with an acute cerebral in‐farction and admitted to the hospital within 72 h .Plasma copeptin levels were measured by double antibody enzyme linked immu‐nosorbent assay and neurological impairment were evaluated by the national institutes of health stroke scale score (NIHSS) after hospitalization .The patients were divided into mild ,moderate and severe groups according to NIHSS score .At the same time ,60 healthy adults were selected as control group .Unfavorable outcome was defined as a modified rankin scale score>2 .The correlation of plasma copeptin levels with 3 month unfavorable outcome was analyzed .Results Upon admission ,plasma copeptin level in pa‐tients was statistically significantly higher than that in healthy controls (P<0 .01) ,the highest was found in severe subgroup (P<0 .05) .Multivariate logistic regression analysis revealed that copeptin was independently associated with unfavorable outcome within 3 months (OR=4 .403 ,95% CI:1 .120-8 .328 ,P<0 .05) .Conclusion Copeptin levels contribute to mirror the initial infarction se‐verity and even bear an association with poor outcome of patients with cerebral infarction within 3 months .

Objective:To propose a method to evaluate the total body water (TBW) of patients on hemodialysis with urea kinetic model (UKM), and compare it with body surface bio-impedance spectrum (BIS) analysis. Methods:We enrolled 24 adult patients with end stage renal disease (ESRD) without hyper-catabolism in our dialysis center. All of them had been on hemodialysis for more than 3 months. TBW was measured with BIS analysis immediately before and after dialysis session, and one hour after hemodialysis session. Spent dialysate was collected; blood samples were taken before and one hour after hemodialysis session, TBW before hemodialysis session were calculated by UKM. Results:Patients were 6 men and 18 women, the average age was (51.2?13.5) years and the average time on dialysis was (33.2?36.7) months. Causes of ESRD included chronic glomerulonephritis (8 patients), diabetic nephropathy (1 patients), hypertensive renal damage (1 patients), interstitial nephritis(two patients), chronic pyelonephritis (two patients). The average ultrafiltration volume was (2.7?1.0) L (0.5-4.4 L) . Plasma urea concentrations were (23.06?5.76) mmol/L and (8.15?2.06) mmol/L before and one hour after hemodialysis session, respectively. There was no significant difference between TBW measured immediately after and one hour after hemodialysis session with BIS analysis [(29.9?8.8) L and (29.8?8.6) L, respectively; average difference was (0.1?0.9)L, P=0.70]. These two measurements correlated very well (Pearson r=0.99, P