1.Correlative study on TCM syndrome and laboratory indices in 265 cases of diabetic nephropathy renal failure
Xin MOU ; Danyang ZHOU ; Jinxi ZHAO
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(12):-
Objective:To discuss relativity of different TCM syndrome with sex,age and laboratory indices in 265 cases of diabetic nephropathy renal failure,and this work is meaningful to open out the naure of TCM syndrome.Methods:The research proceeded the questionary of diabetic nephropathy established according to task group.Including commonly instances,four diagnostic methods information of TCM and correlative laboratory indices.Canonical correlative analysis was adopted to research the relativity of laboratory indices with different TCM syndrome.Results:The results of canonical correlative analysis displayed that phlegm-dampness and BMI,dampness-turbid and creatinine clearance rate,deficiency of yin and glycosylated hemoglobin had pertinence(P
2.Research on knowledge discovery based on non-interactive literatures analysis of diabetic nephropathy diagnose and therapy
Hongjie GAO ; Yingkai ZHAO ; Meng CUI ; Jinxi ZHAO
International Journal of Traditional Chinese Medicine 2011;33(8):710-712
Objective To explore more effective treatments of Chinese medicine for diabetic nephropathy.Methods This study took opened non-relevant documents knowledge discovery method to study the diabetic nephropathy literatures in order to find the hidden links among literatures. A valuable scientific hypothesis will be put forward upon the study to guide or implement a new knowledge discovery after it acquire the agreement of experts. Results Use keywords frequency statistics method based on open non-related literature knowledge discovery, the anti-inflammatory herbs were filtered out Most herbs with anti-inflammatory effects had the functions of clearing away heat and detoxicating, expelling wind and removing dampness. Conclusion Prescriptions with the functions of clearing away heat and detoxicating, expelling wind and removing dampness may delay the occurrence and development of diabetic nephropathy and play an important role in curing this disease.
3.Effect of immune enhanced enteral nutrition on immune function in postoperative patients with gastric cancer:a Meta-analysis
Jinxi WANG ; Lei ZHAO ; Qiang GUO ; Kun ZHANG ; Xiaodong MA
Cancer Research and Clinic 2017;29(6):398-403
Objective To evaluate the effect of immune enhanced enteral nutrition on immune function in postoperative patients with gastric cancer by using meta-analysis. Methods The databases of PubMed, the Cochrane Library, CNKI, CBM, VIP and Wanfang Data were used to search randomized controlled trials (RCT) about the effect of immune enhanced enteral nutrition and conventional enteral nutrition on immune function in postoperative patients with gastric cancer. The retrieval time span was from inception to Sept 1, 2016. The studies were screened according to the inclusion and exclusion criteria, the data were extracted and the quality was evaluated by 2 reviewers independently. Besides, the meta-analysis was conducted by using RevMan 5.3 software. Results Meta-analysis included 5 RCT, 216 cases in total. The results showed that the immune parameters of immune enhanced enteral nutrition such as IgA (MD=0.18, 95 % CI 0.09-0.27, P< 0.001), IgG (MD= 0.76, 95 % CI 0.43-1.09, P< 0.001), IgM (MD= 0.13, 95%CI 0.07-0.20, P<0.001), CD3 (MD=4.74, 95%CI 2.99-6.48, P<0.001), CD4 (MD=3.6, 95%CI 2.14-5.06, P< 0.001), CD4/CD8 (MD= 0.58, 95 %CI 0.20-0.97, P< 0.003) were significantly higher than those of conventional enteral nutrition after 9 or 10 days of gastric surgery. The CD8 level of conventional enteral nutrition were higher than immune enhanced enteral nutrition after 9 or 10 days of gastric surgery (MD = -1.26, 95 %CI-2.21 - -0.30, P= 0.01). The difference between two groups had no statistical significance in immune parameters such as IgA, IgG, IgM, CD3, CD4, CD8, CD4/CD8 after 1 day of gastric surgery (P>0.05). Regarding to cellular factor, the IL-6 level of immune enhanced enteral nutrition was lower than conventional enteral nutrition after 9 days of gastric surgery (MD=-77.40, 95 %CI-112.25 - -42.55, P< 0.001). The difference between two groups enteral nutrition had no statistical significance about IL-6, TNF-αafter 1 day of gastric surgery, TNF-α, IL-2 after 9 days of gastric surgery (P> 0.05). Conclusion Immune enhanced enteral nutrition for postoperative patients with gastric cancer can improve and enhance the immune function under stress, and reduce the excessive inflammatory reaction, which is more conducive to the safety of patients with gastric cancer.
4.Trinity of physique differentiation, diagnosis of disease and syndrome differentiation and clinical practice of diabetes
Jinxi ZHAO ; Yingjun DING ; Yinhui WANG ; Jing LI
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(08):-
It expounded the important position of physique in etiology and process of disease,investigated essence and application of physique in disease control,revealed the classifi cation of physique in three yin three yang.Also it expounded the signif icance of diagnosis of disease in TCM theory and clinical therapy,then revealed basic pathogenesis of diabetes:damaged yin and qi due to inner heat.Then it discussed the syndrome differentiation in the TCM treatment and suggested that it should combine with physique differentiation and diagnosis of disease.At last it expounded the trinity of physique differentiation,diagnosis of disease and syndrome differentiation in treating diabetes and its complication.
5.Commentary on study of diabetic nephropathy pathogenesis
Yinghui WANG ; Bo PANG ; Jing LI ; Jinxi ZHAO
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(03):-
To summarize current pathogenesis theories of diabetic nephropathy,focusing on kidney theory,spleen theory,collateral disease theory,toxicity injuring kidney meridian collaterals theory and micro-zhengjia theory.As for the study development,new research idea has been put forwards which highlights basic TCM syndrome study,clinical trial and experimental study,as it will improve the research works in this field.
6.An approach for the measurement of the surface area of scalp flap over the cranial defect after decompressive craniectomy.
Qinhu ZHANG ; Lanjuan LIU ; Ninghui ZHAO ; Jinxi ZHAO ; Lian GAO ; He SUN ; Xinling SHI
Chinese Journal of Medical Instrumentation 2013;37(6):401-403
OBJECTIVETo introduce a simple, fast and universal measuring method used in measurement of the surface area of scalp flap over the cranial defect after decompressive craniectomy.
METHODSThe first step: CT images of the patient with craniocerebral trauma after decompressive craniectomy were obtained and imported into Mimics. The second step: based on the defined threshold, the 3D geometric models of brain and skull were reconstructed after the original Dicom format pictures three-dimensional processed by Mimics. The third step: based on the two builded 3D models, utilizing the segmentation and measurement tools of Mimics to conduct cutting, splitting and measuring operations for the 3D model of brain. The forth step: estimating the surface area of scalp flap over the removed bone flap by using mathematical computation methods.
RESULTSThe application of the introduced method estimated the surface area of scalp flap over the cranial defect of different people with different position of craniocerebral trauma.
CONCLUSIONSThis paper introduces a simple, fast and universal new measuring method. We can conveniently estimate the surface area of scalp flap by using the introduced method.
Decompressive Craniectomy ; methods ; Humans ; Imaging, Three-Dimensional ; Models, Anatomic ; Scalp ; surgery ; Surgical Flaps ; Tomography, X-Ray Computed
7.Talking about education and hospital of Korean medicine
Jinxi ZHAO ; Yonghua XIAO ; Li ZHU ; Huiyi SUN ; Xi LI ; Zhenzhen CHU
International Journal of Traditional Chinese Medicine 2015;(1):8-11
Being introduced in Korean peninsula, Chinese medicine, which is called Korean medicine in Korea, has caused great influence in Korean ethnomedicine, culture and living.Korean medicine takes an important part in Korean medical education and medical treatment. This paper introduces the origin of Korean medicine, the current mode and feature of Korean medicine education, as well as the overview and characteristic of Korean Hospital Affiliated Qing Xi University and Korean Hospital Affiliated Daejeon University. The mode of Korean medical education and hospital can offer reference for Chinese medicine education.
8.Application of Mixed Programming Skill of VC++ and Matlab in Development of MRI Software
Jinxi WANG ; Xiaoyan WANG ; Yun YUE ; Xin ZHAO ; Changyuan WANG ; Weigang ZHONG
Chinese Medical Equipment Journal 1989;0(03):-
Objective To realize K space image reconstruction by using VC++ and Matlab in the development of MRI software.Methods VC++ called FFT(Fast Fourier Transform Algorithm) function of matlab math dlls to realize transforming the data from k space to real space.Results Image reconstruction was realized successfully for the clinical demand.The development circle and programming workload were greatly reduced.Conclusion The mixed programming by VC++ and Matlab can reduce the developing process and improve the reliability of the software.
9.lncRNA GAS5 enhances the radiosensitivity of colon cancer cells by down-regulating miR-223 expression
Xiaomin LI ; Haoliang ZHAO ; Peng MA ; Jinxi WANG ; Xiudong GUO
Chinese Journal of Radiological Medicine and Protection 2018;38(10):734-740
Objective To explore the effect of lncRNA of growth arrest-specific 5 (lncRNA GAS5) on the radiosensitivity of colon cancer cells by targeting miR-223.Methods The expressions of lncRNA GAS5 in a few of colon cancer cell lines were detected by real-time quantitative PCR (qPCR).The cell lines with low expression level of lncRNA GAS5 were selected for subsequent study.The effect of overexpression of lncRNA GAS5 on the radiosensitivity of colon cancer SW480 cells was detected by cell cloning experiments.The target gene miR-223 of lncRNA GAS5 was predicted and validated by the bioinformatics database starBase and dual luciferase reporter assays.qPCR was used to detect the expression of miR-223 in various colon cancer cell lines and the influence of lncRNA GAS5 overexpression on the expression of miR-223 in SW480 cells.Results Compared with normal human colonic epithelial cells (NCM460),the expressions of lncRNA GAS5 in the colon cancer SW480,LOVO,HT-29 and SW620 cell lines were significantly lower(t =15.25,8.69,14.42,11.62,P < 0.05),with the lowest level in SW480 cells.Both overexpression of lncRNA GAS5 and down-regulation of miR-223 significantly increased the radiosensitivity of colon cancer cells by decreasing cell survival fraction (at 8 Gy,lncRNA GAS5,t =13.51,P < 0.05;anti-miR-223,t =14.93,P < 0.05)and promoting apoptosis (lncRNA GAS5,t =8.30,P < 0.05;anti-miR-223,t =7.32,P < 0.05).Bioinformatics analysis showed that the 3'sequence of lncRNA GAS5 contained the binding sites with miR-223.After overexpression or downregulation of lncRNA GAS5,the expression of miR-223 was enhanced or reduced.Conclusions The lncRNA GAS5 promotes the apoptosis of colon cancer cells and inhibits its survival by targeting miR-223 expression,thereby increases the radiosensitivity of colon cancer cells.
10. Efficacy and mechanism of Xiaobanxia Decoction and categorized formula in preventing and treating delayed chemotherapeutic vomiting
Jiyan ZHAO ; Jinxi LI ; Yimin ZHANG ; Zhenfei DONG ; Junning WANG
International Journal of Traditional Chinese Medicine 2020;42(2):138-143
Objective:
To observe the pharmacodynamic effect of