1.Differential Expression of CXCR4 in Conventional High-grade and Low-grade Central Osteosarcoma and Its Prognostic Implications.
Hye Rim PARK ; Jinwon SEO ; Patrizia BACCHINI ; Franco BERTONI ; Yong Koo PARK
The Journal of the Korean Bone and Joint Tumor Society 2012;18(1):20-27
PURPOSE: The chemokine receptor CXCR4 has been reported to be aberrantly expressed in human cancer and has been shown to participate in cancer metastasis. We compared the expression of CXCR4 in conventional high-grade and low-grade central osteosarcomas, and determined if an association between CXCR4 expression and prognosis could be made. MATERIALS AND METHODS: We performed the immunohistochemistry for CXCR4 in a total of 63 patients with osteosarcoma and determined the relationships according to the clinicopathologic variables and overall survival rates. RESULTS: CXCR4 was detected in 76.3% of conventional high-grade osteosarcoma patients and in 36% of low-grade central osteosarcomas. Diffuse expression was noted in 47.4% of the high-grade osteosarcomas and all low-grade cases were focal positive. CXCR4 expression was significantly correlated with histologic grade (p<0.0001). While overall survival rate was reduced significantly with increased CXCR4 expression (p=0.0058), higher histologic grade (p<0.0001), and younger age (p=0.0140), survival rate did not correlate with gender, tumor size, or AJCC stage. CONCLUSION: Our results suggest that CXCR4 expression is associated with higher-grade tumors and with poor prognosis for osteosarcoma patients.
Humans
;
Immunohistochemistry
;
Neoplasm Metastasis
;
Osteosarcoma
;
Prognosis
;
Survival Rate
2.Small Cell Carcinoma of the Uterine Cervix.
Jinwon SEO ; Jong Sun CHOI ; Geunghwan AHN
Korean Journal of Pathology 2003;37(6):373-378
BACKGROUND: Small cell carcinoma of the uterine cervix is a rare and aggressive neoplasm, for which there have been few diagnostic markers. METHODS: Eleven cases of small cell carcinoma of the uterine cervix were retrieved from pathology files. Immunohistochemical stains were performed for two epithelial markers (cytokeratin [AE1/AE3] and epithelial membrane antigen [EMA]) and four neuroendocrine markers (neuron-specific enolase [NSE], CD56, chromogranin, and synaptophysin). RESULTS: Of the nine cases followed up, two with initial distant metastasis died within one year. All seven remaining cases were diagnosed at stage Ib, and showed no evidence of recurrence. Nine cases were positive for one or more epithelial markers. Two cases showed positivity for epithelial markers in less than 10% of their tumor cells. The immunoreactivity for neuroendocrine markers showed variable results; four cases were reactive for chromogranin, four were positive for synaptophysin, and seven were reactive for CD56. All cases were positive for NSE. CONCLUSIONS: A diagnostic panel of chromogranin, synaptophysin, and CD56 rather than a single marker would be useful for the diagnosis of small-cell carcinoma of the uterine cervix.
Carcinoma, Small Cell*
;
Cervix Uteri*
;
Coloring Agents
;
Diagnosis
;
Female
;
Mucin-1
;
Neoplasm Metastasis
;
Pathology
;
Phosphopyruvate Hydratase
;
Recurrence
;
Synaptophysin
3.Expression of Carbonic Anhydrase IX Correlates with Histologic Grade and Metastasis in Osteosarcoma.
Hye Rim PARK ; Jinwon SEO ; Patrizia BACCHINI ; Franco BERTONI ; Yong Koo PARK
Korean Journal of Pathology 2010;44(4):384-389
BACKGROUND: Carbonic anhydrase IX (CA9) is reportedly overexpressed in several types of carcinomas, but little is known about the expression pattern of CA9 in osteosarcoma. We aimed to assess the prevalence of CA9 expression and its prognostic implications in osteosarcoma patients. METHODS: We compared immunohistochemical expression of CA9 between conventional, high-grade and low-grade, central osteosarcomas. Specimens were obtained before chemotherapy and stained with anti-human CA9 antibody. We also evaluated the histologic grade, presence of metastasis, and patient prognosis. RESULTS: Among 38 samples of conventional high-grade osteosarcoma, 22 (57.9%) tumors displayed CA9 overexpression. Twenty-five cases of low-grade central osteosarcomas were all negative (p < 0.0001). CA9 expression was significantly associated with the presence of metastasis (p = 0.0010). The overall survival rate was significantly reduced with increased CA9 expression (p = 0.0012), higher histologic grade (p < 0.0001), and younger age (p = 0.0140). However, the overall survival rate was not significantly correlated with gender, tumor size, or American Joint Committee on Cancer stage. CONCLUSIONS: CA9 expression is a frequent and tumor-specific event in osteosarcoma. CA9 expression is associated with higher grade tumors, metastasis and poor prognosis for the osteosarcoma patients.
Antigens, Neoplasm
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Carbon
;
Carbonic Anhydrases
;
Humans
;
Joints
;
Neoplasm Metastasis
;
Osteosarcoma
;
Prevalence
;
Prognosis
;
Survival Rate
4.A Case of Hemangioma in the External Auditory Canal with Pulsatile Tinnitus.
Hyeonseok KIM ; Jinwon SEO ; Hyo Jeong LEE
Korean Journal of Otolaryngology - Head and Neck Surgery 2017;60(3):140-143
Hemangiomas are relatively common in the head and neck region, but their occurrence in the temporal bone are extremely rare. The hemangioma of the external auditory canal (EAC) is a rare otologic entity as only 22 cases of hemangioma of the EAC have been reported worldwide. Here we report a patient presenting with pulsatile tinnitus, which turned out to be caused by capillary hemangioma arising from the posterior medial portion of external auditory canal touching the tympanic membrane. Surgical excision of the tumor was successful. The clinical manifestations and management of benign vascular lesions of the EAC are discussed with a review of literature.
Ear Canal*
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Head
;
Hemangioma*
;
Hemangioma, Capillary
;
Humans
;
Neck
;
Temporal Bone
;
Tinnitus*
;
Tympanic Membrane
5.Giant Multilocular Cystadenoma of the Prostate: A Case Report.
Chang Ohk SUNG ; Jinwon SEO ; Sang Yong SONG
Korean Journal of Pathology 2004;38(2):106-108
Large multilocular cysts and cystic neoplasms of the prostate are very rare. A healthy 52-year-old man presented with acute urinary retension. Physical examination revealed a large abdominal mass. Pelvic MRI showed a 15x10x9 cm, lobulated, and multiseptated cystic mass in the pelvic cavity. Exploration laparotomy revealed a large cytic mass that compressd and displaced the urinary bladder antero-laterally, and adhered to the prostate and the sigmoid colon. Macroscopically, the mass was grayish white colored, multilocular cysts containing reddish-brown serous fluid. Microscopically, the tumor was composed of glands and cysts lined by the prostatic-type epithelium in the fibrous stroma. The prostatic nature of the lesion was confirmed by the lining epithelium expressing prostate-specific antigen.
Colon, Sigmoid
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Cystadenoma*
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Epithelium
;
Humans
;
Laparotomy
;
Magnetic Resonance Imaging
;
Middle Aged
;
Physical Examination
;
Prostate*
;
Prostate-Specific Antigen
;
Prostatic Neoplasms
;
Urinary Bladder
6.The Analysis of Indeterminate Category in Thyroid Fine Needle Aspiration.
Soo Kee MIN ; Jinwon SEO ; Sun Young JUN ; Kwangseon MIN ; Hye Rim PARK
Korean Journal of Pathology 2010;44(6):657-661
BACKGROUND: Descriptive diagnosis reports have been causing some problems in communication. Our institution decided to use the category diagnosis system since June, 2008. So we evaluated the effectiveness of this change. METHODS: The category system is composed of unsatisfactory, suboptimal for diagnosis but suggestive of, most probably benign, indeterminate, suspicious for malignancy and malignancy. We evaluated 1,525 cases from June, 2008 to September, 2009. We analyzed 159 cases of the indeterminate category. RESULTS: Among the 159 cases, 21 were re-aspirated and 63 underwent an operation. The diagnoses of the re-aspirated cases were 2 positive for malignancy, 5 indeterminate, 13 most probably benign, and 1 unsatisfactory. The surgical diagnoses were 39 malignancies, 2 follicular adenomas and 1 Hurthle cell adenoma, and 21 benign lesions. Re-aspiration for the indeterminate cases could help decide whether the lesions need to be operated or not at above 70%. The indeterminate category could predict the surgical diagnosis of the thyroid nodule with statistical significance when the subcategories were indicated (p < 0.001). CONCLUSIONS: The category diagnosis is replacing the descriptive diagnosis for the thyroid fine needle aspiration. The indeterminate category is useful and effective for making the decision to operate and especially when the indeterminate subcategories are used.
Adenoma
;
Biopsy, Fine-Needle
;
Thyroid Gland
;
Thyroid Nodule
7.Primary Extracranial Meningioma Presenting as a Cheek Mass.
Jin Woo MAENG ; Yong Hyun KIM ; Jinwon SEO ; Si Whan KIM
Clinical and Experimental Otorhinolaryngology 2013;6(4):266-268
Meningioma is well known as common disease of the central nervous system, whereas primary extracranial meningioma is rare, representing 1% to 2% of all meningiomas. We have experienced a case of primary extracranial meningioma presenting as a right cheek mass. The tumor was completely excised via a right lateral rhinotomy incision. Histopathologic examination confirmed the diagnosis of primary extracranial meningioma.
Central Nervous System
;
Cheek*
;
Diagnosis
;
Meningioma*
8.Solitary Pulmonary Lymphangioma in an Adult: A Brief Case Report.
Hye Jong SONG ; Joungho HAN ; Kwhanmien KIM ; Kyung Soo LEE ; Jinwon SEO
Korean Journal of Pathology 2008;42(2):125-127
Solitary pulmonary lymphangiomas are extremely rare. We report here on an unique case of solitary pulmonary lymphangioma in an adult. A well-circumscribed, 6 cm-sized, pleural based lesion with fluid attenuation was found in a 50-year-old Korean male. He had no previous history of disease or trauma. The wedge-resected lung revealed an ill-demarcated lesion with multiple microscopic cysts and the cystic walls had loose intervening stroma.
Adult
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Male
;
Female
;
Humans
;
Cysts
9.Ultrasound and MRI Findings of Giant Cell Fibroblastoma in the Abdominal Wall: Radiologic-Pathologic Correlations
Soyoon MIN ; Sun Young PARK ; Jinwon SEO ; Sung Hye KOH ; Kwanseop LEE
Journal of the Korean Radiological Society 2020;81(1):237-242
Giant cell fibroblastoma (GCF) is a rare soft-tissue sarcoma of fibroblastic origin. To the best of our knowledge, only one brief description of the MRI findings of GCF exists in the pathologic literature. Herein, we report a case of histologically proven GCF in a 3-year-old boy who underwent ultrasonography and MRI of a superficial mass in the abdominal wall.
10.Diffuse-Type Tenosynovial Giant Cell Tumor of the Tendon Sheath in Both Wrists
Sunah HEO ; Sun-Young PARK ; Jinwon SEO ; Sung Hye KOH ; In Jae LEE
Journal of the Korean Radiological Society 2021;82(1):250-254
Diffuse-type tenosynovial giant cell tumor (D-TSGCT), previously known as pigmented villonodular synovitis, is a locally aggressive neoplasm that may arise from the synovium, bursa, or tendon sheath. D-TSGCT is usually monoarticular and can be classified into intra- and extra-articular forms, the latter of which is rarer. Here, we report a case of D-TSGCT in a 64-year-old female that involved the entire flexor and extensor tendon sheaths of both wrists. We describe the ultrasonography and MRI findings, as well as review the relevant literature.