Objective To explore the resistance to antibacterial drugs in Mycoplasma pneumoniae (Mp) isolated from the chil-dren with community acquired pneumonia (CAP) in Shiyan area .Methods A total of 426 throat swabs and serum samples were collected from children patients with suspected CAP in Shiyan area from Feb .2013 to Apr .2015 .The throat swabs were used to culture Mp .The serum Mp-IgM was detected by ELISA ,the positive samples were confirmed by plate culture method ,meanwhile , the drug sensitivity test was taken .Results Among 426 children cases ,69 cases were confirmed as Mp infection ;the drug suscepti-bility test results showed that the resistance rate of Mp was 76 .8(53/69) to erythromycin ,65 .2% (45/69) to azithromycin ,18 .8%(13/69) to levofloxacin ,4 .3% (3/69) to tetracycline ,4 .3% (3/69) to minocycline and 24 .6% (17/69) to gentamicin .Conclusion Mp is one of the key pathogens of CAP in Shiyan area ,which is severely resistant to macrolide .The treatment should choose sensi-tive drugs as the treatment drug ,but it is important to consider the toxicity and adverse reactions of these several kinds of drugs to children .The blind medication should be avoided .

Objective To explore the efficacy and safety of irinotecan as neoadjuvant chemotherapy (INAC) plus radical surgery (RS) for cervical cancer.Methods According to International Federation of Gynecology and Obstetrics (FIGO),81 cases were divided into Ⅱ B,ⅡA,and Ⅰ B2 groups.According to the tests of UGT1A1 gene polymorphisms,we adjusted the injection dose of irinotecan.The parameters were analyzed,including the efficacy,operation time and bleeding volume,postoperative pathology,survival time,and adverse reactions.The articles on irinotecan or paclitaxel combined with cisplatin for neoadjuvant chemotherapy between 2005 and 2015 were collected,and compared.Results The effective rate of chemotherapy was 81.5％ (Ⅰ B2 group:85.7％;Ⅱ A group:83.3％;and ⅡB group:72.2％),operation time was (5.3 ± 1.1) h,and blood loss was (781 ± 361.7) ml.After chemotherapy,37 cases were delayed diarrhea,70 cases were nausea,48 cases were vomiting,and 40 cases were bone marrow suppression.The infiltration rate,operation time,and blood loss on Ⅱ B group was significantly higher than that on Ⅱ A and Ⅰ B2 groups(P ＜ 0.05),and there was no significant difference in the chemotherapy efficiency,invasion depth,lymphatic metastasis,survival time and adverse reactions(P ＞0.05).Compared to three articles,the total effective rate in this study was higher than that in previous studies,also in Ⅱ A and Ⅱ B group.Conclusions Irinotecan chemotherapy regimens combined with cisplatin is effective and well tolerated.It is worthy of popularization and application.Detection of UGT1A1 gene polymorphism has guiding significance for chemotherapy regimen on irinotecan combined with cisplatin.