For observation of the therapeutic effect of some foods on hyperlipi-demia in men, study was perfomed with subjects of hyperlipidemia by using mushroom, soya bean meat, beans, garlic, spring onions, prawn, chives, walnut seeds, peanut seeds, fishes etc. After 3 months treatment, the average values of serum total cholesterol and triglyceride were decreased significantly. The percentage of serum high-density lipoprotein cholesterol in the total cholesterol was increased from 24.7% to 31.3%; the percentage of serum low-density lipoprotein cholesterol was decreased from 61.8% to 49.2%. The curative rates of subjects with hypercholesterolemia were 93.3%, and the subjects with hypertriglyceridemia were only 50.0% and 57.1%. The effective rates were 79-87%.

The therapeutic effects of Chinese mushroom on hyperlipidemia in male adults were investigated. The subjects taking mushroom tablet (10g/day) were divided into ordinary diet (n = 18) group and hypernutritive diet (n = 16) group. After 3-month treatment, the mean values of serum total cholesterol and triglyceride were significantly decreased by 59.5 (P

The effects of 4 kinds of edible oils on serum lipid levels, morphological changes of cardiovascular tissues, fatty acid compositions of various tissues and platelet function in rats had been observed. 40 adult Wistar rats fed semi-synthetic diet containing edible oil to supply 41% energy were divided into 5 group, i. e. control group (18.7% energy from fat), soy bean oil group, peanut oil group, lard group and rape seed oil group. The animals were fed the diets and water ad libitum for 2 months. The results showed that the lard gave the most serious detrimental effect but the soy bean oil was the least. The difference between these two groups was significant. The platelet number was 223?109/L and aggregation rate was 21.8% of the soy bean oil group but. the lard group 149?109/L and 30.2%. The composition (%) of PUFA in tissues was higher and that of saturated fatty acid was tower in soy bean ou group than those in lard group.Electron microscopical studies showed that the animals with vascular endothelial cells changes were more and the pathological changes were more serious in the lard group than those in the soy bean group.All groups except rape seed oil group increased weights in the experi-mental period at the similar rate. Rape seed oil group gained very little weights and aggregated more C22:1 especially in myocardium.

Objective: To observe the effects of nutrients-compound supplementation (NS) on cognitive function. Method: Forty six young male volunteers were randomly divided into 2 groups, NS and control (CT). NS group was supplemented with nutrients-compound while CT group received placebo for 60 d.The cognitive function of all volunteers were examined by 《CHANG-AN Handbook of Group Intelligence Test》 and Wechsler Memory Scale(WMS). Their vitamin status was assessed by 4-h load test at the end of experiment. Results : The vitamin nutriture of NS group was significantly better than that of CT. Many achievements of cognitive test of NS group were obviously increased compared to that before supplementation or that of CT. The visual responding time was shortened in 3 tests and the error number was decreased in 1 test of NS group, while no significant change was observed in CT group. Conclusion: Supplementation with the nutrients-compound is beneficial to improvement of cognitive function such as learning, memory and understanding.

Ankylosing spondylitis (AS) is a type of autoimmune disease that predominantly affects the spine and sacroiliac joints. However, the pathogenesis of AS remains unclear. Some evidence indicates that infection with bacteria, especially Gram-negative bacteria, may have an important role in the onset and progression of AS. Recently, many studies have demonstrated that mesenchymal stem cells (MSCs) dysfunction may contribute to the pathogenesis of many rheumatic diseases. We previously demonstrated that MSCs from AS patients exhibited markedly enhanced osteogenic differentiation capacity in vitro under non-inflammatory conditions. However, the properties of MSCs from AS patients in an inflammatory environment have never been explored. Lipopolysaccharide (LPS), a proinflammatory substance derived from the outer membrane of Gram-negative bacteria, can alter the status and function of MSCs. However, whether MSCs from AS patients exhibit abnormal responses to LPS stimulation has not been reported. Autophagy is a lysosome-mediated catabolic process that participates in many physiological and pathological processes. The link between autophagy and AS remains largely unknown. The level of autophagy in ASMSCs after LPS stimulation remains to be addressed. In this study, we demonstrated that although the basal level of autophagy did not differ between MSCs from healthy donors (HDMSCs) and ASMSCs, LPS-induced autophagy was weaker in ASMSCs than in HDMSCs. Specifically, increased TRAF4 expression in ASMSCs impaired LPS-induced autophagy, potentially by inhibiting the phosphorylation of Beclin-1. These data may provide further insight into ASMSC dysfunction and the precise mechanism underlying the pathogenesis of AS.
Autoimmune Diseases ; Autophagy* ; Bacteria ; Gram-Negative Bacteria ; Humans ; In Vitro Techniques ; Membranes ; Mesenchymal Stromal Cells* ; Pathologic Processes ; Phosphorylation ; Rheumatic Diseases ; Sacroiliac Joint ; Spine ; Spondylitis, Ankylosing* ; Tissue Donors ; TNF Receptor-Associated Factor 4*

Surgery is a classic traditional method for the treatment of early-stage esophageal cancer, and it is also recognized as an effective first-choice method in the medical community. With the development of endoscopic technology, esophagus-preserving comprehensive treatment of esophageal cancer has almost the same or even better effects in some aspects in the treatment of early esophageal cancer than surgery. Many clinical guidelines have also recommended it as the first-choice treatment for early esophageal cancer. The room for surgical treatment of esophageal cancer has been further compressed. This article discusses the comprehensive treatment model of esophageal cancer from the perspective of thoracic surgery, aiming to find a new position of thoracic surgery in the treatment of esophageal cancer.