1.Identification of the Thioredoxin-Like 2 Autoantibody as a Specific Biomarker for Triple-Negative Breast Cancer.
Jee Min CHUNG ; Yongsik JUNG ; Young Pil KIM ; Jinsue SONG ; Soyeon KIM ; Ji Young KIM ; Mira KWON ; Jung Hyun YOON ; Myo Deok KIM ; Jun Kyoung LEE ; Da Yoon CHUNG ; Seo Yun LEE ; Jooseong KANG ; Ho Chul KANG
Journal of Breast Cancer 2018;21(1):87-90
Triple-negative breast cancer (TNBC) has a higher risk of death within 5 years of being diagnosed than the other forms of breast cancer. It is the second leading cause of death due to cancer among women. Currently, however, no diagnostic blood-based biomarker exists to identify the early stages of TNBC. To address this point, we utilized a human protein microarray system to identify serum autoantibodies that showed different expression patterns between TNBC and normal serum samples, and identified five autoantibodies showing TNBC-specific expression. Among them, we selected the thioredoxin-like 2 (TXNL2) autoantibody and evaluated its diagnostic relevance by dot blot analysis with the recombinant TXNL2 protein. We demonstrated that the TXNL2 autoantibody showed 2- to 6-fold higher expression in TNBC samples than in normal samples suggesting that serum TXNL2 autoantibodies are potential biomarkers for TNBC.
Autoantibodies
;
Biomarkers
;
Breast Neoplasms
;
Cause of Death
;
Female
;
Humans
;
Protein Array Analysis
;
Triple Negative Breast Neoplasms*
Result Analysis
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