Objective:With biomechanical trial, the feasibility was investigated using the indentation method to assess myocardium viscoelasticity and the change of viscoelasticity after old myocardial infarction was also investigated. Method:The old myocardial infarction moldel was established using ligating the left anterior descending branch under thoracotomy.With the instrument of indentation, creep test was applied to the normal and old infarcted canine ventricular myocardium. Results:The viscoelastic parameteres of normal group:E164?9kPa,E2565?148kPa,E∞57?7kPa,?1.7?0.9?105kPa.s;old infarcted group: E1130?30kPa,E21076?466kPa,113?27kPa,?2.8?1.0?105kPa.s.The difference of parameteres in above two groups is significant in statistics(P

Objective To explore the clinical efficacy of cetuximab combined FOLFOX chemotherapy on colon and colorectal cancer.Methods Forty patients with colon and colorectal cancer were randomly divided into observation group and control group,and 20 cases for each group.Patients in control group were treated with oxaliplatin + leucovorin + 5-fluorouracil,and in the observation group were given cetuximab (the first does was 400 mg/m2 at the first week,then the second week and follow weeks was 250 mg/m2 1 time/week for 6 week) plus the treatment as control group.The clinical efficacy,adverse effect and 1-year survival in the two groups were recorded.Results The total effective rate and clinical benefit rate in observation group were 60％ (12/20)and 85％ (17/20) respectively,which significantly higher than the control group (30％ (6/20) and 65 ％ (13/ 20),x2 =18.18,10.67,P ＜ 0.05).Skin rash rate in observation group was 55％ (11/20),which was significantly higher than that of control group (15％ (3/20),x2 =35.16,P ＜0.05).Half-year survival rate and 1-year survival rate of patients in observation group were 75％ (15/20) and 45％ (9/20) respectively,significantly higher than the control group (50％ (10/20) and 25％ (5/20),x2 =13.33,8.791,P ＜ 0.05)~ Conclusion Treatment scheme of Cetuximab combined FOLFOX chemotherapy is proved to be an effect of treating advanced colon and colorectal and be with the low adverse effect.

Ischemia-reperfusion injury is a pathophysiological process caused by a number of gene expression changes,with the development of artery occlusion-reperfusion and surgery involved in vascular,such as thrombolytic therapy,cardiopulmonary bypass heart surgery and organ transplants,etc.it has been more and more important.Gene chip technology provides a powerful means for the systematic study of the mechanisms of incidence and prevention of ischemia-reperfusion injury,for its unique advantage in high throughput,high-efficiency,large-scale research.Since gaining importance in recent years,it has been widely used in various organs and tissues,and has achieved some progress.In this paper,the application of gene chip technology in the incidence and prevention of ischemia-reperfusion injury of various organs and tissues in recent years is given a certain summary.

Objectives: Inquirying the ability of the earlier diagnosis and studying the surgical management of intra and extra middle skull base tumors. Methods: A retrospective study has been made on 43 cases of malignant skull base tumor extended into cavernouse sinus. CT and MRI evaluation were made for all patients. Different approaches have been utilized to remove tumors. Results: In early period there was no obviously clinical sign. 5 year survival rate was 35.1%. Seven cases of no removing totally tumors in cavernous sinus had been alive for 7 months. Conclusions: The symptoms of skull base carcinoma is less, which often leads to false diagnosis and management. Total resection via different approaches may improve clinical results.

A biological study was made to estimate the influence of excess dietary zinc, in vivo, on iron and copper status and their antagonism. Chicks were randomly divided into four groups (n= 22 each) according to body weight and were fed on experimental diet with different amounts of zinc, iron and copper for 28 days. The results were as follows; 1. Excess dietary zinc (400ppm) caused retardation of growth rate in experimental chicks, hypochromic anemia, elevation of blood and tissues (liver, kidney) zinc levels and lowering iron, copper and ceruloplasmin content,and eryth-rocyte Cu-Zn-superoxide dismutase activity; 2. Copper alone supplemented up to 40ppm to the excess zinc diet was able to improve the growth rate, body copper status and Cu-Za-superoxide dismutase activity, but no effect on anemia and body iron status; 3. Iron and copper were supplemented up to 400ppm and 40ppm respectively to excess zinc diet at same time, all the parameters were similar to the chicks fed basal diet. These data suggested that supplement of iron and copper at proper proportion to excess zinc diet can prevent the adverse effects of excess zinc on chicks.

OBJECTIVE To prevent the nosocomial infection event in the clinical laboratory. METHODS To enhance the conception of self-protection,amplify necessary rules and regulation,fine technique training,establish the health-record of the department staff,purchase the facilities of protection,and disinfect the instrument and environment of laboratory even the test report sheet. RESULTS By means of above mentioned measures and management,it could control in most degree of nosocomial infection in clinical laboratory,and ensure the safety and health of the department staff. CONCLUSIONS The nosocomial infection event of clinical laboratory can be prevented by amplification of necessary rules and regulation as well as enhancement of the management.

OBJECTIVE:To screen the formulations of bioadhesive danazol suppository,and to study its drug release in vitro.METHODS:Hydroxypropyl methylcellulse(HPMC),polyethylene glycol(PEG)6000and PEG600were employed in the bioadhesive sustained-release formulation.Suppositories were prepared and the correlation between drug release rate from suppositories and the ratio of HPMC to PEGs used in the formulae was studied.RESULTS:HPMC retarded drug release,and drug gradually released in the12-hours period when the ratio of HPMC to PEGs was1∶6.5;the law of drug release was conformed to weibull models and mono-exponential models.CONCLUSION:HPMC,PEG6000and PEG600were suitable to the formulation of bioadhesive danazol suppositories,and HPMC could slow down the drug release from the this preparation;the best ratio of HPMC to PEGs was1∶6.5.

60 years senile autopsy cases w as about half of that of western countries,most of latent carcinomas were well a nd moderate differentiated.HGPIN was closely associated with prostatic adenocar cinoma.

Objective To investigate the survival principle of SARS-conarovirus (SARS-Cov) in environments and to explore the inactivation effect of chlorine and chlorine dioxide on SARS-Cov with the aim of providing some basis for blocking its'main route of transmission. Methods SARS-Cov were added into the excrement samples, urine samples and other water samples and were disinfected by sodium chlorite and chlorine dioxide. The survival ability of SARS-Cov and the effects of those two disinfectants on the inactivation of SARS-Cov were observed. Results The survival of SARS-Cov changed with the variation of temperature in external environment.It was showed that SARS-Cov could only survive for 2 days in hospital sewage, domestic sewage and dechlorinated tap water, while 3 days in excrement samples, 14 days in physiological saline and 17 days in urine samples protected from light in vitro at 20 ℃ . At 4 ℃, SARS-Cov could survive for 14 days in all above water samples and 17 days in excrement samples and urine samples. Resistibility of SARS-Cov to disinfectants in sewage sample was lower than those of E. coli and f2 phage. At the same disinfectant dosage or residual chlorine concentration , chlorine had better inactivation effect than chlorine dioxide did.The residual chlorine concentration of more than 0.5 mg/L or chlorine dioxide concentration of more than 2.19 mg/L was enough for the complete inactivation of SARS-Cov in sewage, but not enough for E. coli and f2 phage. Conclusion The survival time of SARS-Cov was shorter and more susceptible to chlorine and chlorine dioxide in external environment.