Objective:With biomechanical trial, the feasibility was investigated using the indentation method to assess myocardium viscoelasticity and the change of viscoelasticity after old myocardial infarction was also investigated. Method:The old myocardial infarction moldel was established using ligating the left anterior descending branch under thoracotomy.With the instrument of indentation, creep test was applied to the normal and old infarcted canine ventricular myocardium. Results:The viscoelastic parameteres of normal group:E164?9kPa,E2565?148kPa,E∞57?7kPa,?1.7?0.9?105kPa.s;old infarcted group: E1130?30kPa,E21076?466kPa,113?27kPa,?2.8?1.0?105kPa.s.The difference of parameteres in above two groups is significant in statistics(P

Objectives: Inquirying the ability of the earlier diagnosis and studying the surgical management of intra and extra middle skull base tumors. Methods: A retrospective study has been made on 43 cases of malignant skull base tumor extended into cavernouse sinus. CT and MRI evaluation were made for all patients. Different approaches have been utilized to remove tumors. Results: In early period there was no obviously clinical sign. 5 year survival rate was 35.1%. Seven cases of no removing totally tumors in cavernous sinus had been alive for 7 months. Conclusions: The symptoms of skull base carcinoma is less, which often leads to false diagnosis and management. Total resection via different approaches may improve clinical results.

Ischemia-reperfusion injury is a pathophysiological process caused by a number of gene expression changes,with the development of artery occlusion-reperfusion and surgery involved in vascular,such as thrombolytic therapy,cardiopulmonary bypass heart surgery and organ transplants,etc.it has been more and more important.Gene chip technology provides a powerful means for the systematic study of the mechanisms of incidence and prevention of ischemia-reperfusion injury,for its unique advantage in high throughput,high-efficiency,large-scale research.Since gaining importance in recent years,it has been widely used in various organs and tissues,and has achieved some progress.In this paper,the application of gene chip technology in the incidence and prevention of ischemia-reperfusion injury of various organs and tissues in recent years is given a certain summary.

Objective To explore the clinical efficacy of cetuximab combined FOLFOX chemotherapy on colon and colorectal cancer.Methods Forty patients with colon and colorectal cancer were randomly divided into observation group and control group,and 20 cases for each group.Patients in control group were treated with oxaliplatin + leucovorin + 5-fluorouracil,and in the observation group were given cetuximab (the first does was 400 mg/m2 at the first week,then the second week and follow weeks was 250 mg/m2 1 time/week for 6 week) plus the treatment as control group.The clinical efficacy,adverse effect and 1-year survival in the two groups were recorded.Results The total effective rate and clinical benefit rate in observation group were 60％ (12/20)and 85％ (17/20) respectively,which significantly higher than the control group (30％ (6/20) and 65 ％ (13/ 20),x2 =18.18,10.67,P ＜ 0.05).Skin rash rate in observation group was 55％ (11/20),which was significantly higher than that of control group (15％ (3/20),x2 =35.16,P ＜0.05).Half-year survival rate and 1-year survival rate of patients in observation group were 75％ (15/20) and 45％ (9/20) respectively,significantly higher than the control group (50％ (10/20) and 25％ (5/20),x2 =13.33,8.791,P ＜ 0.05)~ Conclusion Treatment scheme of Cetuximab combined FOLFOX chemotherapy is proved to be an effect of treating advanced colon and colorectal and be with the low adverse effect.

A biological study was made to estimate the influence of excess dietary zinc, in vivo, on iron and copper status and their antagonism. Chicks were randomly divided into four groups (n= 22 each) according to body weight and were fed on experimental diet with different amounts of zinc, iron and copper for 28 days. The results were as follows; 1. Excess dietary zinc (400ppm) caused retardation of growth rate in experimental chicks, hypochromic anemia, elevation of blood and tissues (liver, kidney) zinc levels and lowering iron, copper and ceruloplasmin content,and eryth-rocyte Cu-Zn-superoxide dismutase activity; 2. Copper alone supplemented up to 40ppm to the excess zinc diet was able to improve the growth rate, body copper status and Cu-Za-superoxide dismutase activity, but no effect on anemia and body iron status; 3. Iron and copper were supplemented up to 400ppm and 40ppm respectively to excess zinc diet at same time, all the parameters were similar to the chicks fed basal diet. These data suggested that supplement of iron and copper at proper proportion to excess zinc diet can prevent the adverse effects of excess zinc on chicks.

Objective To determine whether sleep structures,the waveform components of NREM and rapid eye movement (REM) sleep, and the relationship between sleep variables and mental status are altered. Methods Totally 16 Alzheimer's disease(AD) patients and 16 age-matched controls were studied for two consecutive nights.All cases were video-monitored during the recordings of electroencephalography,electro-oculography,electrocardiography,electromyography in chin,and nasal airflow. Results (1) Compared with normal controls,duration of total sleep ( F =6.30, P =0.017 9),stage Ⅱ sleep ( F =16.03, P =0.000 4),and REM sleep ( F =9.84, P =0.002 1) were remarkably decreased,but waveform components of slow-wave (stage Ⅲ-IV) sleep ( F =11.50, P =0.004) were increased in AD patients.(2) Sleep spindle duration and density,and its relative and absolute power,and K complex density ( F =13.64～79.11, P

Objective:To study the surgical skills of reconstruction of the skull base after resection of skull base tumors.Methods:Thirty-one cases of skull base reconstruction were studied.Galeo-pericranial flaps were used for anterior cranial base defects and tempero muscle flaps for the middle skull base respectively.Results:All the 31 patients with skull base tumors,underwent reconstruction of the skull base of whom,30 experienced no complications,but 1 died of CSF leak.Conclusion:Galeo-pericranial flaps and tempero muscle flaps are reliable materials for the reconstruction of the skull base.

Component separation technique in recent years both at home and abroad is mainly used in the repair of abdominal wall defects and abdominal wall reconstruction,especially for the great defect of the abdominal wall repair.Combined with laparoscopic minimadly invasive techniques,synthetic patch reflects the technology advantage in the abdominal wall reconstruction.This paper focuses on the surgical principle of component separation technique,indications,advantages,methods of operation,complications and related progress

In order to establish more simple and effective rat orthotopic lung transplantation models, 20 rats were divided into donor and recipient groups. Rat lung transplantation models were established by using improved cuff technique. All the 10 operations were accomplished successfully. The mean operative time of recipients was 45 +/- 4 min. The survival time was over 30 days after lung transplantation. The checks of X-ray were almost normal. There was no significant difference in the blood gas analysis before and after clipping the right hilum (P > .05). This method is more simple, applicable and requires less time.
*Lung Transplantation/methods ; Models, Animal ; Rats, Sprague-Dawley