Objective To analyze the level of blood lipid in healthy Tibetans and Han natives in Lasa through the detection of serum lipids. Methods The serum TC, LDL-C, HDL-C and TG were detected by Hitachi 7060 automatic biochemical analyzer in 13 037 healthy adults (8 163 Tibetan individuals and 4 874 Han individuals). After that, all data were statistically analyzed by age (Tibetan:298 cases of ＜25 year-old group, 1 136 cases of 25-year-old group, 2 039 cases of 35-year-old group, 2 119 cases of 45-year-old group, 1 580 cases of 55-year-old group, 905 cases of 65-year-old group, 86 cases of ≥75 year-old group; Han population:307 cases of ＜25 year-old group, 1 254 cases of 25-year-old group, 1 874 cases of 35-year-old group, 1 022 cases of 45-year-old group, 272 cases of 55-year-old group, 129 cases of 65-year-old group, 16 cases of≥75 year-old group), sex (Tibetan: men 4 505 cases, women 3 658 cases; Han population:men 2 976 cases,women 1 898 cases). Results The average TC, HDL-C and LDL-C levels of Tibetans were (5.07 ± 1.10), ( 1.54 ±0. 49) and (3.33 ± 1.31 ) mmol/L respectively while the average levels of Han natives in Lasa were (4. 60 ± 0. 98 ), ( 1.45 ± 0. 44 ) and ( 2. 85 ± 1.0g ) mmol/L, which showed the levels of the Tibetans were higher than the Han natives in each age group(t =24. 78, 10. 53,21.46, P＜0.05). The TG levels was 1.38 ( 0. 20-2. 99 ) mmol/L in Tibetans and 1.54 (0.20-2.99)mmol/L in Han natives ( F = 224. 88, P ＜ 0. 05 ). The prevalence of total dyslipidemia was 75. 32% in Tibetans and 69. 02% in Han natives of Lasa. The prevalence of total dyslipidemia was 78. 56% in male and 65.42% in female. There were significant differences in both ethic and sex groups(x2 = 9. 678, 44. 138,P ＜0. 05). Conclusion The TC, LDL-C levels and prevalence of dylipidemia in Tibetans are higher than the Han residents in Lasa.