1.Analysis of etiological changes of atrial fibrillation in Zhanjiang
Jinrong XU ; Wubiao CHEN ; Pinghu CHEN
Chinese Journal of Primary Medicine and Pharmacy 2009;16(7):1224-1225
Objective To analyze the etiological changes of atrial fibrillation(AF) in Zhanjiang. Methods The etiology of 592 AF cases during 1990~1997 were analyzed, and 610 cases during 2000~2007 were analyzed as comparison. Results Rheumatic heart disease(36.8%) was main etiology of AF during 1990~1997. But coronary artery disease(33.1%) has surpassed rheumatic heart disease recently, and the hyperthyroidism and undetermined-e-tiology of atrial fibrillation were decreasing. The etiology of atrial fibrillation in different age groups was significantly different(P <0.05 or P <0.01). Conclusion The etiology of atrial fibrillation changes every year,and age is a pre-dictable factor to the etiology of atrial fibrillation.
3.The observation of right chest electric admittance plethsmography in patients with coronary heart disease
Huimin CHEN ; Xuesi WU ; Jinrong ZHANG
Chinese Journal of Interventional Cardiology 1996;0(04):-
The right chest electric admittance plethsmography (RCEAP) is a simple no invasive and reliable method in detecting the blood flow volume in the pulmomary artery and vein, an indirection of the left heart function. In this clinical study, the RCEAP, left heart catheterization for measurement of LVEDP and coronary angiogram and echocardiography for investigating the LVEF were performed on 34 patients with coronary heart disease. Of these 34 patients,24 had single or no left vessel lesion (Group A), 10 had left main coronary artery or its double branches lesions (Group B) ;8 underwent percutaneous trans-lumin coronary angioplasty (PTCA)and 10 had coronary artery bypass graft (CABG).The data obtained were analysed and compared to evaluate their respective diagnostic values. Correlation analysis demonstrated the values of hc/hz ratio, ha/hz ratio were moderated with LVEDP(r = 0. 68 or 0. 73,P
4.Distribution and drug resistance of common pathogens in Xinjiang area
Huixia YI ; Jinrong CHEN ; Na SU ; Yumei LIU
International Journal of Laboratory Medicine 2015;(8):1047-1049
Objective To investigate the distribution and drug resistance of common pathogens in Xinjiang ,aare so as to provide references for reasonable use of antibiotics .Methods The strains of common pathogens isolated from patients in the First Teaching Hospital of Xingjiang Medical University from 2012 to 2013 were collected ,and the drug susceptibility testing were performed by K‐B methods recommended by CLSI .Results Totally 18 374 strains were isolated ,among them 13 323 strains were gram negative and 5 051 strains were gram positive .Escherichia coli ,Klebsiella pneumoniae ,Staphylococcus aureus ,Acinetobacter baumannii and Pseudomonas aeruginosa occupied the top 5 .Most of strains were isolated from sputum (accounted for 36 .1% ) .Escherichia coli and Klebsiella pneumoniae showed high resistance rate to cefazolin sodium ,cefotaxime and quinolones .The detection rate of ESBLs pro‐ducing Escherichia coli and Klebsiella pneumoniae were 48 .4% and 41 .7% ,respectively .The resistance rate of Pseudomonas aerug‐inosa to commonly used antibiotics was 10 .0% ~20 .0% .Methicillin resistant staphylococcus aureus(MRSA) accounted for 44 .7%of all Staphylococcus aureus ,and no strains of Staphylococcus resistant to vancomycin ,teicoplanin and Linezolid were found .Conclu‐sion Gram negative bacteria are the most common strains isolated from clinical in this area ,and strains are mainly isolated from samples of respiratory tract and genitourinary tract ,and the situation of drug resistance is severe ,which indicate the clinicians should strengthen the monitoring of drug‐resistant bacteria and promote rational use of antimicrobial agents .
5.Existing Problems and Strategies of Medical Equipment Management in CPAPF's Hospitals
Jinrong JIANG ; Jing LI ; Hongmei CHEN ; Yuhong LI
Chinese Medical Equipment Journal 1993;0(05):-
The reason on existing problems of medical equipment management in CPAPF's hospitals are discussed and analyzed from lack of management and maintainer, the phenomenon of highlighting use while ignoring management, without timely equipment maintenance and strict system implementation, and then to put forward the main ways of medical equipment management that the introduction of talent, diathesis enhancement, emphasis training, strict operating standards, implementing system and strengthen standardization management and the establishment sense of cherishing and managing equipment, which can provide strategies and ways for medical equipment management in CPAPF.
6.Analysis of epidemic characteristics and clinical features of inpatients with pertussis in 2012-2014
Cong DOU ; Fengqin LIU ; Chunyan GUO ; Jinrong WANG ; Xing CHEN
Chinese Journal of Applied Clinical Pediatrics 2016;31(20):1559-1562
Objective To provide basis for the diagnosis,treatment,prevention and control of pertussis by analyzing serological test findings and clinical features of inpatients.Methods Serological test findings (including outpatients and inpatients) of suspected cases and medical records diagnosed as pertussis (severe group and non-severe group) were analyzed in Shandong Provincial Hospital Affiliated to Shandong University from January 1,2012 to December 31,2014.This retrospective study was conducted to explore the epidemiological characteristics,clinical manifestations,image manifestations of pertussis in recent years.Results The incidence of pertussis was obviously higher in 2014 than the previous 2 years,nearly 10 times than that of 2013;summer and autumn were high-occurrence seasons;pertussis was found predominately in children under 6 years old,as 68%-80%,and the majority of them were 3 months-1 year old and 4-6 years old,and there was a notable increase in children more than 6 years old in 2014;the clinical manifestations tended to be atypical,primarily spasmodic cough (79.01%,64/81 cases),cyanosis (60.49 %,49/81 cases),vomiting after cough (35.80%,30/81 cases),conjunctiva haemorrhage (22.22 %,18/81 cases) apnea or heart rate decrease(9.88%,8/81 cases),and whooping cough (7.41%,6/81 cases).There were significant differences(all P < 0.05) in age (t =2.940),paroxysmal cyanosis (x2 =4.505),elevated white blood cell count (x2 =4.410),and lymphocyte percentage increase(x2 =7.830) between severe group and non-severe group.There was no statistical difference in sex(x2 =0.847),season (x2 =0.178),spasmodic cough (x2 =0.097),whooping cough (x2 =0.002),conjunctiva hemorrhage (x2 =0.395),apnea (x2 =0.395) and fever (x2 =0.301) between the 2 groups (all P > 0.05).Mixed infection with mycoplasma was most common.Imaging manifestations of pertussis were not specific,and they might manifest uneven density,patchy inflammatory infiltrates and atelectasis.Conclusions The morbidity of pertussis is rising and atypical cases is increasing in these years,and severe cases are seen most frequently in small infants,it is necessary to perfect the laboratory test methods and immunization strategy.
7.Determination of Serum Concentration of Phenobarbital by RP-HPLC
Bifeng LI ; Huiping FENG ; Jinrong JIA ; Jing WANG ; Qingqing CHEN
China Pharmacy 2007;0(26):-
OBJECTIVE: To determine the concentration of phenobarbital(PBB) in serum by RP-HPLC.METHODS: The analytical column was C18.The mobile phase consisted of methanol-water(44∶56) at a flow rate of 1.0 mL?min-1.The detection wavelength was set at 205 nm and the temperature of column was set at 35℃.RESULTS: A good linear relationship was obtained for PBB at a concentration range from 5.08 ?g?mL-1 to 63.50 ?g?mL-1(r=0.999 9).The mean relative recovery was 99.75% and the mean extraction recovery was 96.34%.The intra-day RSD and the inter-day RSD were all less than 4%.CONCLUSION: This method is simple,rapid,accurate,and suitable for therapeutic drug monitoring.
8.Relationship of Functional Dyspepsia with Gastric Mucosal Mast Cells and Plasma Motilin
Haishan CHEN ; Jinrong GONG ; Chaozhong HUANG ; Zhihui LIN
Chinese Journal of Gastroenterology 2015;(9):533-537
Background:Functional dyspepsia(FD)is a commonly seen functional disease which has great impact on patient’s quality of life and mental health,and has got more and more concern by clinicians. Aims:To explore the role of mast cells (MC)and plasma motilin( MTL)in the pathogenesis of FD. Methods:Sixty FD patients including 32 postprandial distress syndrome(PDS)and 28 epigastric pain syndrome(EPS)patients from September 2013 to January 2014 at the Affiliated Hospital of Putian University were enrolled,and 28 healthy volunteers were served as controls(HS group). The number of gastric mucosal MC,plasma MTL level(fasting and 30 minutes after drinking warm water)and gastric emptying time(T1 / 2 )were compared. Results:Compared with HS group,number of gastric mucosal MC was significantly increased (P < 0. 001),plasma MTL level before and after drinking warm water in FD group were significantly decreased( P <0. 001),T1 / 2 was significantly prolonged(P < 0. 001). No significant difference in number of MC was found between PDS subgroup and EPS subgroup(P = 0. 094). Plasma MTL level before and after drinking warm water in PDS subgroup were significantly lower than those in EPS subgroup( P < 0. 001),and T1 / 2 was significantly prolonged( P < 0. 001). Conclusions:Number of gastric mucosal MC is significantly increased in FD patients compared with HS group,suggesting MC may play a role in the pathogenesis of FD. Plasma MTL level is decreased in FD patients,which may be one of the factors involved in the pathogenesis and occurrence of corresponding symptoms of FD.
9.Correlation between cancer-related fatigue and uncertainty about illness among breast cancer inpatients
Chunhua HU ; Huiyi GUAN ; Longmei RAN ; Huaping LI ; Jinrong CHEN
Modern Clinical Nursing 2015;14(9):1-5
Objective To explore the correlation between the cancer-related fatigue and uncertainty in illness among breast cancer inpatients. Methods Totally 90 patients with breast cancer were involved in the study by cancer fatigue scale (CRS) and Mishel's uncertainty in illness scale-adult (MUIS-A). The correlations were analyzed. Results Approximately 100.00%patients experienced fatigue during hospitalization. The total score of uncertainty in illness was 107.51 ± 21.26. There was a positive correlation between each fatigue dimension and uncertainty in illness (P<0.001). Conclusions Cancer-related fatigue is widespread among breast cancer inpatients and sense of uncertainty in illness of patients is at a moderate level. Nursing staff can help patients to reduce disease uncertainty and improve the life quality of patients by strengthening health education , providing comprehensive information support, fully mobilizing patients' social support system.
10.Effect of Methycobal on Neuron Apoptosis of Caspase-3 mRNA Expression in Rat Brain Tissue After Cerebral Ischemia Reperfusion
Jianhua SU ; Yufang CHEN ; Jinrong TANG ; Xinsheng DIN ; Hang XIAO
Herald of Medicine 2016;35(6):574-578
Objective To investigate the effects of methycobal on the expression of Caspase-3 in brain tissue after cerebral ischemia reperfusion in rats. Methods Rats were randomly divided into sham-operation group, model control group, nimodipine group and low-dose methycobal group, high-dose methycobal group(n=30 in each group).Rats in the sham-operation group and model control group were administered intragastrically with 0.9% sodium chloride solution, rats in the nimodipine group were treated with 1 mg . kg-1 . d-1 of nimodipine, rats in the low- and high-dose of methycobal groups were given 50 and 100 μg.kg-1 .d-1 of methycobal, respectively. The rat model of cerebral ischemia reperfusion was established by middle cerebral artery occlusion with suture method for 3 h.Neurological deficit scores were evaluated 24 h after reperfusion.The apoptosis of perifocal cortex cells was detected by TUNEL method and the expression of Caspase-3 was analyzed by RT-PCR 6, 12 and 24 h after reperfusion. Results Neurological deficit scores in model control group, nimodipine group, low-dose methycobal group and high-dose methycobal group were 2.70±0.52, 1.30±0.51, 2.20±0.75 and 1.30±0.81, respectively.Compared with model control group, neurological deficit scores were significantly different in the nimodipine group, low-dose methycobal group and high-dose methycobal group(P<0.05 or P<0.01).There were no significant differences between the high-dose methycobal group and nimodipine group ( P>0. 05 ) . There was a significant difference between the high-dose methycobal group and low-dose methycobal group( P<0. 05 ) . The results of apoptosis by TUNEL were as follows: compared with model control group, the apoptosis decreased obvsiouly in the nimodipine group, low-dose methycobal group, and high-dose methycobal group at each time point.There was significant difference between the high-dose methycobal group and nimodipine group at the end of the 24th hours (P<0.01).Compared with low-dose methycobal group, there were significant differences in the high-dose methycobal group at the end of 6th, 12th and 24th hours(P<0.01 or P<0.05).The results of RT-PCR were as follows: there was expression of caspase-3 mRNA in the perifocal cortex of all groups, with weak expression in the sham-operation group.Compared with the sham-operation group, the expression of caspase-3 mRNA was increased significantly in the model control group(P<0.01).The expression of caspase-3 mRNA was reduced significantly in the nimodipine group, the low-dose methycobal group and high-dose methycobal group as compared with model control group at each time point( P<0.05 or P<0.01) , but it was not significantly different in the low-dose methycobal group and high-dose methycobal group as compared with that of the nimodipine group(P>0.05).There were significant differences between the high-dose methycobal group and low-dose methycobal group at the end of 24 h(P<0.05). Conclusion Methycobal can protect the brain cells from injury after cerebral ischemia reperfusion by adjusting the expression of Caspase-3m RNA, and the high-dose methycobal is more effective.