In CHEN Fu-zheng's Complete Work on Children's Disease,s,there are many special viewpoints and experiences of pediatrics.In theory,he fighted against abusing medicine such as metals,stone,camphol,musk in treatment of infantile convulsion.In diagnosis,further developped the diagnostic methods of infants'feeling pulse and finger veinlet inspection.In treatment,proposed original ideas in syndrome differentiation and treatment of convulsion induced by febrile disease,and elucidated the Febrile theories of ZHANG Zhong-jing,WANG Hai-zang,ZHANG Jing-yue,YU Jia-yan,ZHOU Xu-zhong.There were many external therapies such as lamp,moxibustion,external application,sticking,fumigation,washing,as well as internal therapies,and there were many formulas of classic and convenient.

Objective: To investigate the relationship between undergraduates’ emotional intelligence, personality traits and self-handicapping. Methods: 1094 undergraduates were tested with Self-handicapping Questionnaires、Emotional Intelligence Scale and NEO-FFI. Results: ①Undergraduates’ self-handicapping was negatively correlated with emotional intelligence(P

Objective To study psychological change on anxiety patients with coronary heart disease (CHD) after percutaneous coronary intervention and to explore the effect of psychological intervention on anxiety patients with CHD.Methods The selected 126 anxiety patients with CHD were randomly divided into three groups A,B,C,and 42 cases in each group.Group A of was the control group,group B was the anti-anxiety drug group,group C was the psychological intervention combinded with anti-anxiety drug,and all patients were treated for one month.The self-rating anxiety scale (SAS) scores were recorded in three groups before surgery,after one week and one month treatment.Resluts There was no significant difference in SAS scores in group A before the operation and after 1 week,1 month treatment(respectively(57.14 ±5.63),(55.86 ±5,46),(53.93 ±6.03),P＞ 0.05).After 1 week and 1 month treatment,the SAS score of group C (respectively (42.79 ± 5.82) points,(33.86 ± 5.05) points) and the SAS score of group B (respectively (49.93 ± 6.63) points,(40.93 ± 6.46)points) were lower than those of group A (respectively (55.86 ± 5.46) points,(53.93 ± 6.03) points),and there were significant differences among the three groups(P ＜ 0.05).Conclusion There is no significantly improvement in patient's anxiety after coronary revascularization.Anti-anxiety drug and psychological intervention significantly improve the patient's negative emotions and reduce the incidence of angina.

Objective To discuss the teaching method and effect of teaching-learn-do integration mode in the Basic Nursing Technology.Methods Students of two classes of grade 2010 and two classes of grade 2011 in our nursing college were randomly divided into the experimental group and the control group,they respectively adopted teaching-learn-do integration teaching mode and first-theory-after-practice traditional teaching method.The teaching effect of the two groups by theory and skills testing was compared.Results The experimental groups were better than the control groups in two grades in skill examination results.For the theoretical examination results,the experimental group of grade 2011 was better than the control group,while the two groups of grade 2010 were undifferentiated in theoretical examination.Conclusions Teaching-learn-do integration mode can not only improve students' operating skills,but also promote the theoretical learning,and improve the students' learning ability of independent innovation,suitable for practical and technical-strong course teaching in Basic Nursing Technology.

OBJECTIVE To investigate the drug-resistance status of Escherichia coli(ECO)from various kinds of specimens to provide the scientific evidence for reasonable use of antibiotics.METHODS ECO strains were isolated and identified according to the National Clinical Laboratory Operation Rules.Drug resistance profile was analyzed by K-B method recommended by CLSI.RESULTS Among 275 ECO strains,50.2%(the most highest isolating rate)were isolated from urine.Detection rate of extended spectrum ?-lactamases(ESBLs)producing ECO was 32.4%(89/275).Except for 100% susceptibility to carbopenems,the drug-resistance to 14 antibiotics in ESBLs producers was higher than in the nonproducers.CONCLUSIONS Laboratory department should think highly of the monitoring of ECO to prevent and control the occurrence and prevalence of the nosocomial infection with ECO.

Objective To study the neurotoxic effects of acute exposure of methylmercury at low dose and to provide some experimental data for deeply exploring the early mechanism of neurotoxicity of methylmercury. Methods SD rats were administered with methylmercury chloride by intraperitoneal injection with different doses of 0.05, 0.50 and 5.00 mg/kg and different exposure times of 20 min, 1 h, 4 h, 24 h. Mercury, ACh and AChE contents in rat brains were measured. Results Mercury contents in rat brains significantly increased after 20 min-exposure at both 0.50 and 5.00 mg/kg doses. Significant increase occurred after 4 h exposure at dose of 0.05 mg/kg. ACh and AChE in rat brains significantly changed after 20 min at every dose, showing certain dose-response and time-response relations. Conclusion Changes of ACh and AChE in rat brain after administration of low dose(0.05 mg/kg) and short time(20 min) exposure suggested certain modulation of CNS had been initiated. With the increases of exposure dose and time, methylmercury might begin to accumulate in rat brain and induce the significant changes of ACh and AChE.

Objective: To study the contents of hyperoside in Semen Cuscutae,which grew in different host and different environment.Methods: Hyperoside was determined by HPLC.Results: The content of hyperoside is 0.28%-0.65% in the semen Cuscutae growing in different conditions in Shandong.The content is higher in semen of C.chinensis in Linyi,whose host is Scutellaria baicalensis Georgi.The content of hyperoside is lower in semen of C.australia which grew in Humulus scandens(lour.) Merr.The content has no obvious difference between C.chinensis and C.australis.Conclusions: The content of hyperoside in semen Cuscutae has relation with the hosts.The content increased with the seed mature degree.

Purpose:To study the relationship between the expression of the BRCA 1 protein and clinico pathological characteristics of breast cancer,and to clarify the correlation of the expression of the BRCA 1 protein with expression of p53 and c erbB 2 . Methods:The expressions of BRCA 1 , p53 and c erbB 2 of breast cancer tissues taken from 60 breast cancer patients as well as 10 benign breast disease patients were examined using immunohistochemical LDP method. All tissues were taken from formalin fixed and paraffin embedded breast tumor specimens. We analyzed the correlation of the results with other parameters which included age of onset, family history, histological grade, status of estrogen receptor and progesterone receptor, axillary nodal status and so on. Results:The expression of BRCA 1 was 61.66% (37/60) in breast cancer patients and 0 (0/10) in benign diseases patients. The protein expressed was mainly located in the cytoplasm. The correlation between age of onset and the expression of BRCA 1 was significant (r=-0.295, P

Standardized patient(SP) is playing an important role in medical education.Nevertheless this kind of medical education is not perfect.By use of analyzing the shortcomings in internal medicine education by SP.the effect of SP education will be greatly increased.

Objective To study the risk factors of severe hand-foot-mouth disease (HFMD) among children.Methods The clinical data of 1 570 children with HFMD at Linyi People's Hospital in Shandong Province in 2011 were collected,retrospectively.The data were analyzed using univariate and multivariate Logistic regression.Results The mean age of severe HFMD (including severe and critical HFMD) was (25.0± 14.0) months old,predominantely aged between 1 and 5 years old,while mild HFMD was (27.1±15.8) months (t'=-2.717,P=0.007).There were 61.0％ and 65.9％ boys in two groups,respectively (x2 =3.894,P=0.048).Fever,convulsion,tremor,nausea and vomiting were more frequently seen in severe HFMD.The neutrophil count and the level of creatine kinase in severe HFMD were both significantly higher than that in mild HFMD.Univariate analysis revealed that age (odds ratio [OR]=1.799,95％CI:0.984-1.997),girl sex (OR=1.234,95％CI:1.001-1.522),high fever (OR=2.110,95％CI:1.816-2.452),convulsion (OR=1.878,95％CI:1.578-2.236),nausea and vomiting (OR=1.760,95％CI:1.456-2.128),neutrophil count (OR=1.031,95％CI:1.025-1.037) and creatine kinase (OR=1.002,95％CI:1.001-1.003) were risk factors for severe HFMD.Multivariate Logistic regression showed that high fever (OR =1.751,95％ CI:1.487-2.062),convulsion (OR=1.451,95％CI:1.204-1.749),nausea and vomiting (OR=1.269,95％CI:1.027-1.568),neutrophil count (OR=1.028,95％CI:1.021-1.035) were independent risk factors.Conclusions Body temperature,neurological manifestations and trend of neutrophil counts should be carefully monitored in children with HFMD.Prevention of the development of severe HFMD mainly relies on the identification of risk factors and adoption of precautions in time.