OBJECTIVE:To provide reference for the improvement of pharmaceutical administration in secondary general hospital.METHODS:The problem existing in the pharmaceutical administration in 2 tertiary and 6 secondary general hospitals were evaluated in accordance with the "Practice Regulations of Guizhou Hospital Management Year Evaluation Guidance(Trial)";and the measures for its improvement were put forward.RESULTS & CONCLUSIONS:The hardware construction for the pharmaceutical administration in secondary general hospital can meet the requirements basically,however,the management level is still low and there is long way to go before the management meeting the requirements of evaluation guidance in respect of the implementation of clinical pharmacy,rational use of antibacterials,and the management of special drugs.It is necessary to strengthen the connotation construction,standardize the management and promote the continued development of hospital pharmaceutical management.

Objective To evaluate the impact of integrated information management platform on life style of diabetic patients. Methods A total of 84 diabetic patients were assigned to the intervention group and the control group by random digits table method with 42 cases each. All patients were in the hospital and after discharge given conventional three-tier management model. The intervention group was given comprehensive information management platform, three-tier management model mediated on this basis. The life style, fasting blood glucose, glycated hemoglobin were collected and compared between the two groups before and after intervention. Results After 9 months of intervention, the dietary pattern of the intervention group was more in line with the Chinese Dietetic Association's recommended dietary standard, in which staple food decreased from (343.90 ± 225.61) g before intervention to (311.71 ± 144.46) g, and meat decreased from (61.52 ± 59.73) g before intervention to (50.07 ± 36.16) g, and the lipid content decreased from (32.67 ± 21.31) g before intervention to (28.57 ± 19.52) g, compared with the control group (376.49 ± 129.58), (73.90 ± 55.15), (45.78 ± 20.03) g, there were significant differences(t =2.076, 2.278, 3.841, all P<0.05). The number of physical exercises increased from 30 before intervention to 37 cases, the number of moderate exercise increased from 12 cases before intervention to 20 cases, and the median of exercise scores increased from 11.000 (26.500) points before intervention to 33.000 (23.500) points, compared with the control group 15.000(18.000) points, there was significant differences (Z =3.687, P<0.01). The fasting blood glucose, glycated hemoglobin were (7.73 ± 1.31) mmol/L, (6.75 ±1.81)% after intervention and 8.000(2.200) mmol/L, 7.600(1.600)%before intervention in the intervention group, compared with the control group (8.60 ± 2.25) mmol/L, (8.81 ± 2.63)%, there were significant differences(t =2.111, 4.062, P<0.05 or 0.01). Conclusions Integrated information management platform management mode three-mediated diabetes may urge to improve the existing way of life, better control of blood sugar.

Objective:Two experiments were performed to research the effects of visual field factor on pseudoneglect and to test the theories about neglect and pseudoneglect.Methods:Experiment 1 employed the landmark task and greyscales task in tachistoscopic and forced-choice conditions.Experiment 2 employed the greyscales task and tachistoscopic visual three-field technique.Results:Experiment 1 manifested that greyscales had no crossover effect;the length factor had effect on the greyscales task as the landmark task,but it only affected the bias magnitude,not the error direction.Experiment 2 indicated that the main effect of visual field was significant:when the greyscales were presented in the middle or right,pseudoneglect manifested,but when in the left,pseudoneglect vanished.Conclusion:The results provide evidence supporting the hypothesis that the perceptual distortion derives from the attentional process.

The humanistic quality education of undergraduate clinical medical students is a system of education throughout the whole process of medical education.Some aspects include new career planning education,medical humanities quality courses,social practice,professional courses,clinical practice and evaluation of humanistic quality education need to design and control,which are necessary to achieve a good education results.

Purpose: To study the effect of personality on the mental adjustment of breast cancer patients during operation. Methods: Forty three breast cancer patients were examined by the Eysenck Personality Questionnaire (EPQ) for their personality before operation, and by the Mental Adjustment to Cancer Scale ( MAC) for their mental adjustment reaction before and after operation. Results: ANOVA repeated analysis revealed that the patients characterized by high Psychoticism showed higher scores on Fatalism, and the patients characterized by low Lie showed higher Hopelessness during operation. Conclusions: In the treatment of breast cancer patients, it is necessary to give appropriate psychological treatment according to the patients's individual characteristics.

Objective To investigate the effect and mechanism of adenovirus vector mediated SOCS 3 gene transfection in CD4+ Th cell differentiation and expression of inflammatory cytokines of mouse .Methods The CD4+ Th cells were isolated from spleen of C57bl/6 mouse and cultured .Ad‐SOCS3 were transfected into the CD4+ Th cells .PHA was used for culturing with the CD4+ Th cells .RT‐PCR were used to detect the mRNA expression ,and Western blot were used to detect the protein expression of cytokines .Results Compared with the control group ,the gene and protein expression of T‐bet ,IL‐2 ,IFN‐γ,STAT4 and IL‐12Rβ2 in the transfected group were significantly down‐regulated ,the gene and protein expression of SOCS3 ,GATA‐3 ,IL‐4 ,IL‐6 ,IL‐10 and STAT6 were significantly up‐regulated(P<0 .01) .Conclusion The results indicate that SOCS3 gene transfection can up‐regu‐late SOCS3 mRNA and protein expression in the CD4+ Th cells ,down‐regulate the JAK/STAT pathway ,inhibition of Th1 cell dif‐ferentiation ,and down regulation of inflammatory cytokine gene and protein expression ,and indirectly promote Th2 cell differentia‐tion ,and up the corresponding inflammatory cytokine gene and protein expression .

Objective To study the positions,features and sectional anatomy of the palatovaginal canal and vomerovaginal canal,comparing with CT and MRI findings. Methods The palatovaginal canals in 104 sides and vomerovaginal canals in 60 sides of dry skulls were observed.Three adult cephalic specimens were sliced into celloidin contiguous sections on coronal plane(0.5 mm in thickness) and the results were correlated with the CT studies of 11 patients and MR imaging of a cephalic specimen. Results In dry skulls,the palatovaginal canal displayed as complete canal in 79.8% of the cases,while appeared as groof in 15.4%.There was neither significant canal nor groof in 4.8%.The vomerovaginal canal demonstrated as complete canal in 36.7% of the speciments,while appeared as groof in 33.3%.This canal was communicated with the lateral palatovaginal canal in 15% and it was not detected in 15%.Four typical slices of the celloidin and 3 plane of CT and 3 plane of MRI were selected and the key structures were described.Conclusion The palatovaginal canal and vomerovaginal canal can be well depicted on coronal plane.

Objective To study the effect of dexamethasone on pulmonary fibrosis model induced by bleomycin in rats and the expression of STAT1 and PDGF in lung tissue,and to discuss the possible mechanism.Methods Forty-five Wistar rats were randomly divided into three groups(15 in each group).They were dexamethasone group(DXM group),bleomycin group(BLM group) and control group(NS group):① The DEX group were intratracheally instilled with belomycin(BLM)(5mg/kg,in 1ml 0.9% NaCl solution),and then were treated with dexamethasone 3mg/kg via celiac injection daily;② BLM group were intratracheally instilled with BLM(5mg/kg),and then were treated with saline 3mg/kg via celiac injection daily;③ NS group were intratracheally instilled with saline(5mg/kg),and then were treated with saline 3mg/kg via celiac injection daily.Five rats in each group were sacrificed at 7,14,and 28 days after intratrachel instillation.Histological changes of the lungs were evaluated by HE stain.The bronchoalveolar lavage fluid(BALF) of right lung was gotten and the cells counting as well as differentiation were figured out.The expression of STAT1 and PDGF protein was assessed by immunohistochemistry.Results(1) The total number of inflammatory cells in BALF in BLM group was the highest at day 7 and diminished at day 14 and 28,which was significant different compared with that of the NS group(P

Objective To study the neurotoxic effects of acute exposure of methylmercury at low dose and to provide some experimental data for deeply exploring the early mechanism of neurotoxicity of methylmercury. Methods SD rats were administered with methylmercury chloride by intraperitoneal injection with different doses of 0.05, 0.50 and 5.00 mg/kg and different exposure times of 20 min, 1 h, 4 h, 24 h. Mercury, ACh and AChE contents in rat brains were measured. Results Mercury contents in rat brains significantly increased after 20 min-exposure at both 0.50 and 5.00 mg/kg doses. Significant increase occurred after 4 h exposure at dose of 0.05 mg/kg. ACh and AChE in rat brains significantly changed after 20 min at every dose, showing certain dose-response and time-response relations. Conclusion Changes of ACh and AChE in rat brain after administration of low dose(0.05 mg/kg) and short time(20 min) exposure suggested certain modulation of CNS had been initiated. With the increases of exposure dose and time, methylmercury might begin to accumulate in rat brain and induce the significant changes of ACh and AChE.

The lack of organs has been an crucial limiting factor for Chinese organ transplantation,thus it is in urgent need to effectively increase the number of donor organs.This article holds that,besides through publicity and education to promote unpaid voluntary organ donation,some incentive mechanisms are also required to serve as useful complements.Therefore,organs' origin can be expanded to a certain extent,and the intense supply and demand in organ transplantation can also be eased.Unifying organ transplantation practice in China,this paper explains the necessity of organ donation incentive mechanisms from both theoretical and practical significances,reveals the main elements of the incentive mechanisms,and explores the realization means.