OBJECTIVE:To discuss the effect of folic acid on the homocysteine(Hcy)and flow-mediated vasodilation and cog-nitove function in the treatment of elderly patients with cerebral infarction. METHODS:The data of 198 elderly patients with cere-bral infarction was randomly divided into the observation group and the control group by different medication. Control group was treated with conventional treatment;based on the treatment of control group,observation group was orally treated with Folic acid tabelts 5 mg,once a day. The treatment course of 2 groups was 8 weeks. The Hcy level and flow-mediated vasodilation(FMD)be-fore and after treatment,mini-mental state examination (MMSE) score and incidence of adverse reactions in 2 groups were ob-served. RESULTS:After treatment,Hcy level in observation group was significantly lower than before and control group,FMD was significantly higher than before and control group(P<0.01). MMSE score in observation group was significantly higher than control group(P<0.01). There were no obvious adverse reactions in 2 groups during treatment. CONCLUSIONS:Based on the con-ventional treatment,folic acid can effectively reduce the Hcy level of elderly patients with cerebral infarction,improve the cogni-tive function and reduce the brain tissue damage,with good safety.

Objective To analyze the clinical distribution ,drug resistance and genotyping of bloodstream infection Staphylococ-cus aureus in our hospital .Methods Bacteria identification and drug sensitivity test were performed in 102 strains of Staphylococ-cus aureus isolated by automatic bacteria identification system in our hospital during January 2010 to January 2017 ,and the geno-types were determined by polymerase chain reaction (PCR) .Results Staphylococcus aureus bloodstream infection was the most common in people aged 70- <80 years old (29 .41% ) ,followed by the age of 50- <60 years old (15 .69% ) .The disease was the most common in the intensive care unit (ICU) (29 .41% ) ,followed by hemodialysis room (21 .57% ) .The drug resistance rate to penicillin was the highest (94 .12% ) ,followed by clindamycin (66 .67% ) ,and it was sensitive to vancomycin ,tigecycline ,teicoplanin and linezolid (100 .00% ) .The drug resistance rates of Methicillin-resistant Staphylococcus aureus (MRSA) to penicillin ,clindamy-cin ,erythromycin ,gentamicin ,levofloxacin ,tetracycline ,rifampicin ,ciprofloxacin and ampicillin/sulbactam were significantly higher than those of Methicillin-sensitive Staphylococcus aureus (MSSA) (P<0 .05) .The erm gene carrying rate was 100 .00% .Among MRSA ,there were 12 strains carrying ermA gene and 28 strains carrying ermA+ermC gene .Among MSSA ,there were 38 strains carrying ermB gene and 24 strains carrying ermC gene .The ermC gene accounted for 77 .27% in induced drug-resistant strains .Con-clusion Staphylococcus aureus bloodstream infection is more common in the elderly ,especially in the advanced age ,and it is more common in ICU .The detection rate of MRSA is relatively higher ,and the erm gene carrying rate of Staphylococcus aureus is high . ermA gene is common in MRSA while ermB gene is common in MSSA .MRSA is resistant to several antibiotics .It is recommended to choose vancomycin and tigecycline for antibiotic treatment .