Objective To explore the risk factors of dyskinesias in Parkinson' s disease (PD) patients.Methods Patients with PD who had taken levodopa at least 1 month were recruited according to the United Kingdom Brain Bank (UKBB) Criteria..All patients were divided into dyskinesias group and non-dyskinesias group according to the clinical definition of dyskinesia.The parameters including gender,age,age onset,duration,body weight,UPDRS scale score,and treatment parameter,such as the maximum daily dose of levodopa,the cumulative time of medication of levodopa,levodopa dose per weight of patients with dyskinesias were recorded.Multivariate logistic regression analysis was used to analyze risk factors of dyskinesias.The patients were divided into dyskinesias and no dyskinesias groups based on presence of motor complications.Results The incidence rate of dyskinesias was 7.8％ (11/142) in all 142 patients.Of which,9 cases were with peak-dose dyskinesia,and 2 cases with both wearing-off and dyskinesia.There were statistically significant difference between dyskinesias group and non-dyskinesias group in terms of sex,weight,the maximum daily dose of levodopa and levodopa dose per weight(P ＜ 0.05).The same results appeared between wearing-off group and wearing-off with dyskinesia group (P ＜ 0.05).Multivariate Logistic regression analysis showed that total dose of levodopa(OR =1.846,95％ CI:1.234-2.762,P =0.003) and levodopa dose per weight were independentriskfactors(OR=0.991,95％CI:0.984-0.999,P=0.033).Conclusion The risk factors of dyskinesias in Parkinson's disease is closely linked to total dose of levodopa and levodopa dose per weight.

ObjectiveTo analyze the clinical value of anti-myelin basic protein (MBP) antibody in multiple sclerosis (MS).MethodsDetect the anti-MBP antibody in serum of 56 patients with MS, 30 patients with other neurological diseases (OND)and 36 normal control(NC).ResultsThe positive rate were 78.6% of MS, 50% of OND. There was significant difference amonge MS, OND and NC.ConclusionAnti-MBP antibody detection maybe provided evidence for the diagnosis and therapy of MS.

Objective: To explore the effect of guided half day education in rehabilitation of children with cerebral palsy. Methods: 100 children with cerebral palsy were selected and randomly divided into experimental group and control group according to the length of hospitalization, 50 cases in each group. The control group was given routine rehabilitation treatment and nursing, while the experimental group was given half-day education based on routine rehabilitation treatment and nursing. The changes of gross motor function (GMFM) and daily living activity (ADL) were observed and compared between the two groups before and 6 months after intervention. Results: The GMFM scores of the experimental group before and after intervention were (41.85 ±4.26), (66.85 ±4.73) respectively, and those of the control group were (42.59±3.24), (56.59 ±3.63). There was no significant difference between the two groups (Z=1.33,12.17, P<0.05). The ADL scores of the experimental group before and after intervention were (40.43±9.78), (63.21±12.34), respectively. There were significant differences between the two groups (Z=0.51, 4.42, P < 0.05). After intervention, the scores of five single A, B, C, D and E areas of GMFM in the experimental group were (94.8 ± 18.2), (76.3 ± 16.5), (36.4±16.7), (30.4±14.5), (19.4 ± 15.2), respectively. The control group was (85.1±14.7), (58.5±13.6), (26.1±13.4), (18.3±12.3), (12.7±10.7). There were significant differences between the two groups (Z=2.55-5.89, P<0.05). Conclusion Guided half-day process teaching combined with routine rehabilitation treatment and nursing can improve the gross motor and self-care ability of children with cerebral palsy, and its effect is better than that of simple medical rehabilitation..

Objective To investigate the effect of gonadotropin-releasing hormone antagonist (GnRHa) and gestrinone after laparoscopic surgery in patients with endometriosis.Methods Ninety patients with endometriosis who underwent laparoscopic surgery in our hospital were selected as the subjects.The patients in the control group were treated with gestrinone,while the observation group received GnRHa treatment.Treatment efficacy after treatment,reproductive hormone levels,adverse reactions and recurrence condition were compared.Results The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant (93.3％ vs.71.1％,P ＜ 0.05).The levels of serum reproductive hormone (FSH,LH,E2,PRL) in the two groups were significantly lower than treatment before (P ＜ 0.05),and the levels of FSH,LH in the observation group were significantly lower than the control group (P ＜ 0.05).The incidence of adverse reactions showed no significant difference (P ＞ 0.05).The patients in the two groups were followed up for 1 to 2 years.Among them,9 cases had recurrence in the control group and 3 cases in the observation group,and significant difference was seen between the two groups (P ＜0.05).Conclusion GnRHa therapy is more safe,and effective and has lower relapse rate.

Objective To investigate the effect of gonadotropin-releasing hormone antagonist (GnRHa) and gestrinone after laparoscopic surgery in patients with endometriosis.Methods Ninety patients with endometriosis who underwent laparoscopic surgery in our hospital were selected as the subjects.The patients in the control group were treated with gestrinone,while the observation group received GnRHa treatment.Treatment efficacy after treatment,reproductive hormone levels,adverse reactions and recurrence condition were compared.Results The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant (93.3％ vs.71.1％,P ＜ 0.05).The levels of serum reproductive hormone (FSH,LH,E2,PRL) in the two groups were significantly lower than treatment before (P ＜ 0.05),and the levels of FSH,LH in the observation group were significantly lower than the control group (P ＜ 0.05).The incidence of adverse reactions showed no significant difference (P ＞ 0.05).The patients in the two groups were followed up for 1 to 2 years.Among them,9 cases had recurrence in the control group and 3 cases in the observation group,and significant difference was seen between the two groups (P ＜0.05).Conclusion GnRHa therapy is more safe,and effective and has lower relapse rate.

Objective:To analyze the influential factors of blurred vision after general anesthesia.Methods:The clinical data of 997 patients who underwent elective general anesthesia at The No. 1 People's Hospital of Pinghu from September 2022 to May 2023 were retrospectively analyzed. The data collected included age, sex, body mass index, American Society of Anesthesiologists classification, history of hypertension, history of diabetes, operation duration (specifically whether it exceeded 3 hours), surgical position (whether the patient was in the supine position), operating room temperature, use of penehyclidine hydrochloride, use of muscle relaxant antagonists, use of atropine, blood pressure (specifically whether it was ≥ 30% of the baseline value), fluid input, blood loss, and use of pneumoperitoneum. Collinearity diagnosis and univariate logistic regression analysis were conducted to select factors with statistical significance. Subsequently, multivariate logistic regression analysis was performed.Results:Univariate and multivariate logistic regression analyses showed that age > 65 years ( OR = 1.47, 95% CI: 1.01-2.15, P = 0.043), surgical position (non-supine position) ( OR = 1.54, 95% CI: 1.06-2.25, P = 0.025), operation time exceeding 3 hours ( OR = 1.76, 95% CI: 1.05-2.94, P = 0.031), and the use of penehyclidine hydrochloride ( OR = 4.91, 95% CI: 3.35-7.21, P < 0.001) were identified as factors contributing to postoperative blurred vision in patients undergoing general anesthesia. Conclusion:Factors contributing to postoperative blurred vision in patients undergoing general anesthesia include age > 65 years, the use of penehyclidine hydrochloride during surgery, operation time exceeding 3 hours, and non-supine surgical position. Clinically, it is essential to implement early and effective preoperative education, enhance intraoperative nursing quality, and optimize preoperative medication for general anesthesia to reduce the incidence of blurred vision after surgery.

Objective To investigate the prevalence and related characteristics of alcohol dependence in the Pumi people of Ninglang area in Yunnan Province.Methods By stratified multistage cluster randomization,542 residents were interviewed by psychiatrists using the structural questionnaire MINI-International Neuropsychiatric Interview.Results The prevalence of drinking in the study were 37.3％,13.6％ and 22.5％ for the male,female and the total sample.There were significant differences of alcohol dependence between males and females (x2 =304.310,P＜0.01) in which males were significantly higher than those in females.The current prevalence of alcohol dependence in Pumi people was 4.8％(95％CI=3.0％-6.6％),and standardized current prevalence was 3.3％.The current prevalence of alcohol dependence in males was 9.3％,which was significantly higher than that (2.1％) in females (x2 =14.613,P＜0.01).The prevalence of alcohol dependence in the Pumi people was 6.1％ in the 21-30 years old,and 8.6％ in the 51-60 years old.There were one case of major depression,one case of panic disorder,and five cases of insomnia.Conclusion The prevalence of alcohol dependence in Pumi people of Ninglang areas is high.Alcohol dependence has become one of the most common mental disorders and the public health problem.It is necessary to carry out prevention research in the future.

Objective To use the cognitive reinforcement comprehensive intervention program constructed by our team to intervene in patients with spinal cord injury and evaluate its clinical application effect.Methods A non-randomized trial design was adopted to select 97 patients with spinal cord injury from November 2021 to September 2022.Forty-four patients from March to September 2022 in a Grade A hospital in Hefei City were included in the experimental group,and 53 patients from November 2021 to February 2022 were included in the control group.The cognitive reinforcement comprehensive intervention program was used to intervene in the experimental group,and the conventional rehabilitation nursing was used to intervene in the control group.The intervention lasted for 12 weeks in both groups.The Changsha Montreal Scale,Social Support Rating Scale,Rehabilitation Exercise Self-efficacy Scale,Spinal Cord Injury Independence Rating Scale and Hamilton Anxiety Scale were used to measure the two groups before intervention,1 month after intervention and 3 months after intervention.Results 40 cases in the experimental group and 48 cases in the control group completed the study.Repeated measurement ANOVA showed that the temporal,interactive and intergroup effects of cognitive function scores and anxiety scores were statistically significant(P＜0.05).The time effect and interaction effect of the subjective support dimension score,coping self-efficacy dimension score of the two groups were statistically significant(P＜0.05).One month after the intervention,the cognitive function scores of test group were higher than before intervention and control group,and the anxiety scores were lower than before intervention and control group(P＜0.05).Three months after the intervention,the scores of cognitive function,subjective support dimension and coping self-efficacy dimension of experimental group were higher than those before intervention and control group,and the scores of anxiety level were lower than those before intervention and control group(P＜0.05).Conclusion Comprehensive intervention of cognitive reinforcement can improve the cognitive function of patients with spinal cord injury,delay the process of cognitive impairment,enhance self-confidence,relieve anxiety,and promote physical and mental rehabilitation of patients.

To understand the pathogenicity,virulence genes,drug resistance genes,and drug resistance of Staphylococcus aureus isolated from yaks in some areas of Lhasa and Nagqu City,55 yak nasal swab samples were analyzed for S.aureus in this study.The cocci were isolated and identified,and the carriage of virulence genes and drug resistance genes,as well as the pathogenicity and drug sensitivity of the isolated S.aureus strains,were detected with PCR,artificially infected mice,and the K-B drug susceptibility disk method.Seven strains of S.aureus were isolated from the 55 yak nasal swab samples,with an iso-lation rate of 12.73％.The isolated strains were all pathogenic to mice,with a fatality rate exceeding 60％.These seven strains of S.aureus carried three drug resistance genes(tetM,tet,and mecA)and six virulence genes(seb,sec,clfA,hla,hlb,and nuc).The detection rate of the three drug resistance genes was 100％,whereas the detection rate of the six virulence genes in the isolates ranged from 83.33％to 100％.The resistance rates of the isolated strains to penicillin,ampicillin,and cotrimox-azole reached 85.71％-100％,whereas the resistance rates to tetracycline and ceftazidime were both 28.57％.Thus,yaks in Lhasa and Nagqu cities were found to be infected by S.aureus strains carrying various drug-resistance genes and virulence genes.These strains were highly pathogenic and showed sensi-tivity to most antibacterial drugs.These findings may serve as a reference for treating S.aureus infection in yaks in the cities of Lhasa and Nagqu.