The incidence of allergic diseases has been increasing year by year worldwide.The research of allergen detection,diagnosis of allergic diseases,as well as its prevention and treatment are inseparable from suitable effector cell lines.The current arti-cle highlights the basic characteristics of main effector cell lines for allergic diseases(mast cells and basophils),and focuses on the applications of effector cell lines in allergic diseases.The present review aimed to lay the foundation for the research on diagnosis and treatment for allergic diseases.

IgE-mediated food allergy is a common health problem worldwide, and the incidence of food allergy in China is also increasing gradually in the past decades.However, the traditional diagnostic measurements for food allergen specific IgE (sIgE) are based on the in- vivo or in- vitro tests of the intact allergen extracts, with low specificity and sensitivity, as well as limited diagnostic information.Therefore, the clinical diagnosis of food allergies often requires an oral food challenge test, which increases the suffering and risk of patients.Along with the development of component-resolved diagnostics (CRD) of food allergy, the sIgE against a single allergenic component can be measured quantitatively, thus generating the concept of " CRD" , which makes food allergy diagnosis more accurate and helps people distinguish cross allergens, determine the severity of the disease and the risk of severe allergic reactions, and predict the efficacy of immunotherapy.Besides, the diagnostic accuracy would be enhanced significantly and the reliance on oral food challenge tests would be reduced.In this review, the new progress in the diagnosis of common food allergen components would be summarized, and the advantages of CRD would be discussed.