margin from CTV to PTV.

Objective To identify main factors affecting the research capacity of nursing staff for efficient elevation of such a capacity. Methods 1000 persons were chosen in a random coded sampling for completion of questionnaires, including a general information questionnaire, research capacity self-assessment questionnaire, nursing professional value scale and work satisfaction scale for nursing staff. Results Main factors for the research capacity range from high to low the following: education, work satisfaction, training involvement, cognitive value, and nature of their employer. Beta values of such factors are found to be 0. 323, 0. 234, 0. 182,0. 064, and 0. 062 respectively. Conclusion Administrators of nursing staff need to focus on the development of the work values and satisfaction of nursing staff, on top of developing their research methodology and knowledge. This approach may encourage them to proactively involve in research activities.

Objective To study the characteristics of bone marrow hematopoietic recovery such as absolute neutrophil count (ANC) and platelet (PLT ) after accepting hematopoietic stem cell transplantation in the patients with inv (9) .Methods A total of 39589 cases of definitely diagnosed hematonosis in our hospital from January 2010 to October 2015 served as the research subjects . The R banding technique ,polymerase chain reaction(PCR) and flow cytometry instrument were adopted to check chromosome karyotype ,fusion gene and bone marrow hematopoietic recovery related indicators .Results PML-RARα,BCR-ABL1 ,AML-ETO , EVI1 ,CBFβ-MYH11 ,MLL-AF6 ,AML-AF4 ,SET-NUM214 ,SIL-TALI ,IgH rearrangement ,TCR rearrangement and BCL1-IgH and other fusion gene were detected in the patients with inv (9) hematonosis .The recovery situation after receiving hematopoietic stem cell transplantation in the patients with inv (9):ANC recovered to ＞0 .5 × 109/L on 12 d after transplantation ,PLT recovered to ＞20 × 109/L on 16 d after transplantation .The recovery situation after receiving hematopoietic stem cell transplantation in the patients with noninv(9):ANC recovered to ＞0 .5 × 109/L on 12 d after transplantation ,and PLT recovered to ＞20 × 109/L on 13 d after transplantation .Conclusion The time achieving ANC recovery ＞0 .5 × 109/L after hematopoietic stem cell transplantation in the patients with inv(9) and without inv(9) is almost similar ,while the time achieving PLT count recovery in the patients with inv(9) is slightly longer than that in the patients without inv(9) .

Objective: To evaluate the feasibility of intravoxel incoherent motion diffusion-weighted magnetic resonance imaging (IVIM-DWI MRI) in the evaluation of tumor vascular normalization in a mouse model of colorectal cancer induced by recombinant human endostatin (rhES). Methods: The CT26 colorectal cancer xenograft model of BALB/c mice were established and divided into rhES group and control group, with 20 mice in each group. The mice of rhES group were intravenously injected with rhES 5 mg·kg^-1·d^-1 once daily for 12 days, while the mice of the control group were intravenously injected with the same volume of 0.9% saline. 5 mice of rhES group and control group were randomly selected to perform IVIM-DWI MRI as following times: before treatment and four, eight, twelve days after treatment. The parameters of IVIM-DWI were recorded, including true diffusion coefficient(D), pseudo-diffusion coefficient (D^*) and perfusion fraction (f). Meanwhile, microvessel density (MVD), pericyte coverage and tumor perfusion in tumor tissues were detected by immunofluorescence, respectively. Results: The tumor volumes of control group and rhES group before treatment were (154.42±24.65) mm³ and (174.24±28.27)mm^3, respectively, without statistically significant difference (P=0.440). From day 2 to day 12 after treatment, the tumor volume of rhES group was significantly smaller than that of control group (all P<0.05). There were no statistical significances of D value between the rhES group and control group before and after treatment (all P>0.05). The D^* values of the rhES group were (10.940±2.834)×10^-3mm²/s and (12.940±2.801)×10^-3mm²/s in day 4 and 8 after treatment respectively, significantly higher than (6.980±1.554)×10^-3mm²/s and (7.898±1.603)×10^-3mm²/s of control group (P<0.05). Moreover, compared with control group, the D^* value of rhES group was significantly lower in day 12 (6.848±1.460)×10^-3mm²/s vs (9.950±2.596)×10^-3mm²/s, (P<0.05). The f value of rhES group in day 8 was (0.226±0.021)%, significantly higher than (0.178±0.016)% of control group (P<0.01). The MVD of rhES group was significantly lower than that of control group (P<0.05), while the pericyte coverage and tumor perfusion of rhES group were significantly higher than those of control group in day 4 and 8 after treatment (all P<0.05). In addition, we found D^* value of IVIM-DWI in rhES group was significantly related with MVD, pericyte coverage and tumor perfusion (r=-0.354, r=0.555, r=0.559, all P<0.05). Meanwhile, the f value in rhES group was also significantly related with MVD, pericyte coverage and tumor perfusion (r=-0.391, r=0.538, r=0.315, all P<0.05). Conclusions IVIM-DWI MRI can effectively evaluate the vascular normalization in rhES-induced CT26 colorectal tumor.The parameters D^* and f are closely related to intratumorally microvessel density, pericyte coverage and perfusion, which can effectively monitor the occurrence of tumor vascular normalization time.