1.Changes of serum IL-6 and IL-8 levels in patients with gastric cancer and the clinical relationships with Helicobacter pylori infection
Sanjun DU ; Qibin LYU ; Duo LI ; Huibin GAO ; Jinku SHEN
Journal of Chinese Physician 2017;19(2):250-252,256
Objective To explore the changes of serum interleukin-6 (IL-6),and interleukin-8 (IL-8) in patients with gastric cancers and the clinical relationships with Helicobacter pylori (Hp) infection.Methods Totally 62 cases of patients who were diagnosed gastric cancer in our hospital from January 2013 to September 2015 were selected as the study group,who did not accept anti-tumor therapy.The patients were divided into the Hp positive group (with 53 cases) and Hp negative group (with 9 cases) according to whether the merger of Hp infection.Another 60 normal healthy volunteers of the same age in our hospital for health examination during the same period were selected as the control group.The serum IL-6 and IL-8 levels were detected,and the changes of the factors in the study group and control group were compared and analyzed,as well as the U values of Hp infection.The clinical relationships between the expression levels of the two in patients with gastric cancer and the U values of Hp infection were confirmed.Results The serum IL-6 and IL-8 levels and the U values of Hp infection of the study group were significantly higher than those of the control group (P < 0.05),which in the Hp positive group were significantly higher than those in the Hp negative group (P < 0.05).The levels of serum IL-6 and IL-8 in patients with gastric cancer showed positive correlations with the U value of Hp infection (r =0.457,0.531,P < 0.05).Conclusions The serum IL-6 and IL-8 levels in patients with gastric cancer are much higher than those in normal healthy people,and there are significant positive relationship with Hp infection.It can improve the curative effect of gastric cancer patients by improving the eradication rate of Hp.
2.Effect of quality control circle on reducing the incidence of pressure ulcer during operation
Weijian HUANG ; Hua QU ; Juan YU ; Shuiye XIA ; Liying ZHANG ; Huanlei ZHU ; Yingying ZHANG ; Bin SUN ; Ran ZHANG ; Jinku DU
Chinese Journal of Modern Nursing 2015;21(7):748-751,752
Objective To explore the effect of quality control circle ( QCC) on reducing the incidence of pressure ulcer during operation. Methods The quality control circle was organized by who aimed to reduce the incidence of pressure ulcer for patients undergoing operations. A total of 260 cases of operating patients were selected as control group from May 2013 to July 2013 ( Before the QCC group) and investigated the conditions of the pressure ulcer form during operation. By a series of QCC activity, we set target, found out the cause of pressure ulcer during operation, and took countermeasures to improve quality continually. A total of 282 operating patients had been accounted for the incidence of pressure ulcer from October 2013 to December 2013 (after the QCC group). We compared the skin damage related operation, the knowledge control of pressure ulcer among theatre nurses, standard rate of operation posture, et al. Results After the QCC activities, the rate of pressure ulcer was reduced from 9. 3% to 1. 4%, nursing knowledge control of the pressure ulcer among theatre nurses and standard rate of operation posture were improved obviously compared these of group before QCC (P<0. 05). Conclusions The QCC activities can minimize the incidence rate of pressure ulcer, but promote knowledge control of pressure ulcer among theatre and the standard rate of operation posture.