Objective To understand the distribution of overweight and obesity in 0-5 years old children who were born small for gestational age ( SGA) in Shanghai through a cross-sectional investigation. Methods All resident children aged 0-5 years were included, covering all 18 districts in Shanghai. Health-check cards were prepared for SGA children. The check-up included weight,length/height and head circumference. Body mass index ( BMI) was used to evaluate the overweight and obesity according to the standard of World Health Organization ( WHO) . Results This study investigated 728 602 children aged 0-5 years in Shanghai,and ultimately 23 871 of them were defined as SGA,a-mong whom 9 805(41. 4%) were boys and 14 066(58. 9%) were girls. The BMI of SGA children were higher than that of appropriate for gestational age( AGA) from 4 to 18 months,while for the rest of the time,they were basically the same. There was no difference in changing tendency of BMI between SGA children and those AGA children. The distri-bution of overweight and obesity according to the standard of WHO in SGA boys among different ages was 7. 7% to 20. 7%, and 15. 7% in average;the distribution of SGA girls among different ages was 5. 9% to 18. 3%,and 12. 9% in average. The proportion of overweight at the age of 4-18 months was significantly higher than that of other ages. There was no correlation between overweight at 0-2 years old and overweight at the age of 5(P>0. 05). Conclusions Com-pared with SGA girls,overweight and obesity in SGA boys were more serious. The age of 4-18 months were the period of high incidence of overweight. There was no correlation between overweight at 0-2 years old and overweight at the age of 5.

Almost 3% of newborns are diagnosed as small for gestational age(SGA)worldwide.Born SGA is one of the important causes of perinatal morbidity and mortality,and is also associated with metabolic diseases in adulthood.Low birth weight by itself is insufficient to characterize growth restriction,as it does not include information about the neonate’s body proportionality.Depending on the origin,timing and severity of in-sult,small for gestational age infants are classified into two types:proportionate or symmetric growth restriction (SGR)and disproportionate or asymmetric growth restriction(AGR).There may be differences in physical and neurological development of these two types.This study compares three classification indexes,and to find differ-ences in postnatal growth of these two types.

Objective To evaluate the effect of acupuncture for treating migraine acute attack to offer some evidence‐based basis for clinical application .Methods The Chinese and English literatures on the acupuncture for treating migraine acute attack were retrived from January 1989 to December 2014 ,the literatures were screened according to inclusion and exclusion criteria ,the Meta‐analysis was performed on these chose literatures .Results A total of 5 studies were included and 618 migraineurs were in‐volved ,four literatares were performed the Meta‐analysis ,and 1 literature was performed the description analysis .Meta‐analysis re‐sults showed that there was statistically significant differences between the acupuncture group and the sham acupuncture group in the VAS score reduction value at 2 h[MD=0 .36 ,95% CI:0 .08 ,0 .65 ,P=0 .01] ,4 h[MD=0 .49 ,95% CI:0 .14 ,0 .84 ,P=0 .007] after acupuncture;while when the VAS score was used as the evaluation indicator ,there was no statistically significant differences were found at 2 h[MD= -0 .38 ,95% CI:-0 .83 ,0 .07 ,P=0 .10] ,4 h[MD= -0 .42 ,95% CI:-0 .96 ,0 .12 ,P=0 .12] after acu‐puncture in the VAS score between the acupuncture group and the sham acupuncture group .Conclusion Acupuncture could effec‐tively relieve the intensity of headache in migraine ,the analgesic effect of acupuncture for treating migraine attacks is significantly superior to the sham acupuncture group ,while with the VAS score as the evaluation indicator ,the difference between the acupunc‐ture group and the sham acupuncture group has no statistical significance .

This article reviewed the literatures in this area over the past 5 years according to three parts: simple traditional Chinese medicine external application, combination of traditional Chinese medicine and Western medicine, combination of traditional Chinese medicine and physical therapy, and came to several effective prescriptions.
Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Medicine, Chinese Traditional ; methods ; Phlebitis ; chemically induced ; drug therapy ; Physical Therapy Department, Hospital

Objective: To investigate parents acceptance to the COVID-19 vaccine booster shots for their children aged 3-11 years in Nanjing based on the theory of planned behavior, and to provide a scientific theoretical basis for carrying out COVID-19 booster vaccination among children of this age group. Methods: A total of 1 286 parents of children aged 3-11 years in Nanjing were selected by multistage stratified cluster sampling. A questionnaire survey based on the theory of planned behavior was used to investigate their willingness to vaccinate their children with the COVID-19 booster dose, and structural equation model was used to conduct data analysis. Results: About 90.2% of parents were willing to give their children a booster dose of the COVID-19 vaccine. The model constructed based on the theory of planned behavior could explain 42.2% of the variance of vaccination acceptance. Attitudes and perceived behavioral control had a direct positive effect on parents acceptance to booster dose of the COVID-19 vaccine (path coefficients were 0.47 and 0.18, P <0.01); The direct effect of subjective norms on vaccination acceptance was not statistically significant; Perceived behavioral control and subjective norms could have indirect positive effects on vaccination acceptance through attitudes (path coefficients were 0.27 and 0.13, P <0.01). Conclusion Parents in Nanjing have a higher acceptance to vaccinate their children aged 3-11 years with the COVID-19 vaccine booster dose. The theory of planned behavior shows a good explanatory ability on parents acceptance to vaccinate their children, and attitude plays an important role in the formation of vaccination acceptance.

OBJECTIVETo evaluate the feasibility of developing brain-targeted nasal delivery system of scutellarin by the passage between nase and brain in nasal olfactory area.

METHODThe samples of cerebrospinal fluid (CSF) and blood were prepared by cranial puncture and femoral artery catheterization methods respectively according to the certain sampling time after drug administered. The scuteIlarin concentration of samples were determined by 125 marked method. Pharmacokinetic parameters were calculated by trapezoidal rule. The brain-targeted trendence were evaluated by the value of the index AUC(brain)/AUC(plasma).

RESULTThe distribution of scutellarin in brain following intranasal administration was different between tissues. Drug concentration in olfactory bulb achieved to peak at 5-15 min after intranasal administration, while in brain tissue was 30-60 min. Above all, peak concentration in olfactory bulb and olfactory region respectively were (574.8 +/- 205.), (323.4 +/- 128.3) ng x g(-10, both are higher than CSF, which is (123.2 +/- 29.3) ng x g(-1). Moreover, the distribution of scutellarin given by intranasally in brain was: olfactory bulb (OB) > olfactory region (OR) > cerebrospinal fluid (CSF) > cerebellum(CB) > medulla oblongata (MO) > cerebrum (CR); AUC(0-240) of olfactory bulb, olfactory region and CSF after scutellarin intranasal administration were 5.54, 5.07 and 5.51 times of that after intravenous injection, respectively. And the AUC(0-240) of other brain tissues after intranasal administration were also higher than that after intravenous injection. AUC(brain tissue)/ AUC(plasma) of every brain tissues by intranasally are all higher than that by intravenously remarkably. For instance, 5 min after intranasal administration, the value of AUC(CSF)/ AUC(plasma), AUC(OB)/AUC(plasma), and AUC(CR)/AUC(plasma) were 30.34, 56.93, and 6.14 times of that by intravenously.

CONCLUSIONPart of scutellarin could be straightly transported into brain by the intranasal administration. Its absorption pathway was: the molecule of Scutellarin throughed olfactory mucosa in nasal cavity into olfactory bulb in arachno-hypostegal cavity, and then entered into olfactory region, CSF, cerebrum and cerebellum gradually. It showed that olfactory bulb was the only way for drug molecule to go through nasal cavity into brain. It had a significant trendence of brain-targeted when compared to oral administration and intravenous injection, which indicated a certain feasibility to develop a brain-targeted nasal delivery system for scutellarin.

Administration, Intranasal ; Animals ; Apigenin ; administration & dosage ; pharmacokinetics ; Brain ; drug effects ; metabolism ; Drug Delivery Systems ; methods ; Glucuronates ; administration & dosage ; pharmacokinetics ; Male ; Rats ; Rats, Sprague-Dawley

Objective: To investigate the effect and potential mechanism of HOXC8 on the radiosensitivity of non-small cell lung cancer cell line A549, aiming to provide novel ideas for clinical combined treatment. Methods: The A549 cells with stable knockdown of HOXC8 were constructed by using lentivirus and validated by qPCR and Western blot. The radiosensitivity of A549 stable cell line was assessed by plate clone formation assay. The expression levels of TGF-β₁ and the proteins in the downstream signal pathway after knockdown of HOXC8 were detected by Western blot. Results: The A549 cells with stable knockdown of HOXC8 were successfully constructed. The viability and clonogenic capacity of A549 cells were significantly reduced after silencing HOXC8. Silencing HOXC8 also increased the sensitivity of A549 cells to radiotherapy and significantly inhibited the expression of TGF-β₁ and p-Smad2/3 proteins in the downstream signaling pathway. Conclusion Silencing HOXC8 can increase the sensitivity of A549 cells to radiotherapy probably by inhibiting TGF-β₁ signaling transduction. HOXC8 might play an important role in A549 cells.

Objective To understand the whole level of head nurses ’ servant leadership behavior in Shanghai hospitals , so as to provide theoretical basis for optimal management .Methods A total of 2 000 nurses were chosen from two first-level hospitals , two second-level hospitals and two third-level hospitals from February to March 2012 , by the methods combined with step sampling and cluster sampling .Scale for head nurses ’ servant leadership behavior was used to investigate the whole level .SPSS 19.0 was used to analyze the data , descriptive analysis was used to analyze the scores , one-way anova or t test was used to compare perception of leadership behavior between different clusters , and LSD-t was used for pairwise comparison .P<0.05 indicated statistical significance .Results A total of 2 000 questionnaires were handed out and 1 511 effective questionnaires were recovered ,with the rate of 75 .6%.The average score of head nurses ’ servant leadership behavior in Shanghai hospitals was (84.54 ±17.98), which was higher than the median of the scale which was 60.The recognition degree about easy-going was the highest while the recognition degree about authorization was the lowest.The scores of head nurses from first-level hospitals, second-level hospitals and third-level hospitals were(91.62 ±9.40),(90.53 ±11.49),(80.53 ±17.98), respectively, and the difference was statistically significant (F=61.88,P <0.01).There was statistically significant difference in perception toward head nurses’ servant leadership behavior from nurses of different ages , degrees, titles and genders (P<0.05).And there was no statistically significant difference in perception toward head nurses ’ servant leadership behavior from nurses of different working years and marriage status (P >0.05).Conclusions The level of head nurses’ servant leadership behavior in Shanghai hospitals is comparatively good , but there is still room for improvement , especially for head nurses in third-level hospitals .Evaluation of head nurses ’ servant leadership behavior should consider and control the initialization of nurses , in order to prevent differences of perception from affecting the accuracy .

Objective To investigate the psychological demands of caregivers who take care of severe craniocerebral trauma patients, and to analyze different psychological needs of caregivers in different relation, such as parents, spouses, children, brothers and sisters. Methods We used the Critical Care Family Needs Inventory to investigate 391 relatives of patients in neurosurgical intensive care unit in four hospitals by stratified sampling, in order to understand the psychological demands of people who take care of severe craniocerebral trauma patients. Results The total demand score of 391 caregivers was (136. 63 ± 18. 56),which was at the moderate level. There was significant different demand of different relative caregivers in information factor, proximity factor and assurance factor (F=5. 103, 5. 032, 7. 811, respectively;P<0. 01). Conclusions The psychological demands of caregivers who take care of severe craniocerebral trauma patients had relative high psychological needs. The clinic staffs should pay attention to the difference of demand, and give them psychological care to reduce their psychological stress and prevent mental problems.

Objective To explore the influence of superior support on job-related well-being of nurses. Methods From January 2013 to March 2013, we went on investigating 608 clinical nurses from 4 primary hospitals, 1 secondary hospitals and 2 territory hospitals in Shanghai by stratified sampling method, measured by job-related welling-being scale, positive and negative affect scale, supervisor support questionnaire and personal information questionnaire. Results The total score of 608 nurses′psychological well-being acquired (162. 15 ± 25. 15), while the recognition of superior support was (27. 56 ± 5. 52). There was a positive correlation between superior support and psychological well-being (r =0. 544,P <0. 01), as well as positive emotional experience level of nurses (r =0. 402,P <0. 01), but a negative correlation between superior support and nurses′negative emotional experience level (r= -0. 368,P<0. 01). Conclusions Superior support has an important effect on nurses′ psychological well-being and positive emotional experience in the working environment. Enhancing superior support is to help nurse experience the happiness of work, at the same time to help the nurse earn mental and physical well-being, and reduce occupational tiredness and work stress.