Six kinds of erythemato-squamous diseases have been common skin diseases, but the diagnosis of them has always been a problem. The quantitative data processing method is not suitable for erythemato-squamous data because they are categorical qualitative data. This paper proposed a new method based on group lasso penalized classification for the feature selection and classification for erythemato-squamous data with categorical qualitative data. The first categorical data of 33 dimensions were changed by the virtual code, and then 34th dimension age data were discretized and changed by the virtual code. Then the encoded data were grouped according to class group and variable group. Lastly Group Lasso penalized classification was executed. The classified accuracy of 10-fold cross validation was 98.88% ± 0.002 3%. Compared with those of other method in the literature, this new method is simpler, and better for effect and efficiency, and has stronger interpretability and stronger stability.
Algorithms ; Computational Biology ; methods ; Humans ; Reproducibility of Results ; Skin Diseases ; classification ; diagnosis

Respiratory viruses constantly undergo adaptive changes in long-term competition with the host，and are now able to alter the host metabolism to promote their own replication.As an extremely important part of host cell metabolism，glucose metabolism is closely related to respiratory virus infections.It is known that respiratory viruses can activate aerobic glycolysis in host cells through a variety of mechanisms to rapidly generate ATP，lactate and a series of intermediate metabolites.On one hand，aerobic glycolysis can facilitate viral invasion，replication，and evasion of immune surveillance；on the other hand，it can modulate the functional activities of host immune cells，thereby maintaining immune homeostasis during the elimination of viruses.This shows that respiratory viruses compete with host immune cells for glucose，and the one with the competitive advantage can affect the prognosis and regression of the disease.Therefore，this paper mainly discusses the role of aerobic glycolysis in the pathogenesis of respiratory virus infections，to provide new ideas for the fight against respiratory virus infections.