Objective To explore the effects of nursing intervention in the clinical emergency of organic phosphorus pesticide poisoning. Methods Fifty-six patients with organic phosphorus pesticide poisoning, who were admitted to the Department of Emergency in the Affiliated Hospital of Zhejiang Normal University from May 2012 to May 2013, were selected. They were assigned into observation group and received nursing intervention on the basis of regular nursing care. 56 patients with organic phosphorus pesticide poisoning, who were admitted to the same hospital from April 2011 to April 2012 and received only regular emergency nursing care, were selected as control group. Volume of gastric lavage, duration of gastric lavage, number of cases with overflow of gastric contents during a surgery, and complications were collected in the two groups. The satisfaction rates of patients and their families from the two groups were also sur-veyed after the nursing care. Results The volume of gastric lavage, duration of gastric lavage, cases with overflow of gastric contents during a surgery and the incidence of complications in observation group were all less than those in control group. The satisfaction rate in observation group was 96.4%, in which 28 patients were very satisfied, 26 fairly satisfied, 2 unsatisfied. The satisfaction rate in control group was 75.0%, in which 20 patients were very satisfied, 22 fairly satisfied, 14 unsatisfied. The difference of satisfaction rates between the two groups was statistically significant (P<0.05). Conclusion Strengthening of diet and mental nursing for emergency patients with severe organic phosphorus pesticide poisoning helps safeguard patients ’ life at the meantime, wins high recognition.