Objective: To investigate the prevalence of dyslipidemia among adults in Moyu County, Hotan Prefecture, Xinjiang Uygur Autonomous Region, so as to provide insights into the management of dyslipidemia. Methods: The physical examination data of permanent residents at ages of 18 years and older were collected from Moyu County from 2018 to 2019, including demographic features, height, body weight, blood pressure and blood biochemical parameter measurements. The epidemiological characteristics of dyslipidemia were analyzed among residents. Results: Totally 166 142 adults were investigated, with a mean age of (41.08±15.72) years. There were 77 744 men (46.76%), 34 728 obese adults (20.90%), 5 776 adults with diabetes (3.48%) and 26 294 adults with hypertension (15.83%). The levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were (1.38±0.98), (4.13±1.19), (1.31±0.41) and (2.25±0.77) mmol/L, respectively. The prevalence of dyslipidemia was 29.72%, and the detection rates of high TG, high TC, low-HDL-C and high LDL-C were 9.73%, 4.59%, 19.65% and 1.99%, respectively. The prevalence of dyslipidemia was higher in men than in women (33.97% vs. 25.98%; χ2=1 264.729, P<0.001), and the prevalence increased with age (χ2=539.382, P<0.001) and body mass index (χ2=3 601.833, P<0.001). The prevalence of dyslipidemia was 35.48% among patients with hypertension (χ2=497.251, P<0.001) and 46.07% among patients with diabetes (χ2=766.142, P<0.001). There were 9 059 adults with two and more abnormal blood lipid indexes (18.35%), and the detection rates of two and more abnormal blood lipid indexes were 26.50%, 24.14% and 33.15% among patients with obesity, hypertension and diabetes, respectively. Conclusions The prevalence of dyslipidemia among adults in Moyu County is lower than the national level, and low-HDL cholesterolemia is the most common type of dyslipidemia. The prevalence of dyslipidemia is high among patients with obesity, hypertension and diabetes mellitus, in whom abnormality of multiple blood lipid indexes is measured.

Objective To explore the prevalence and characteristic of Non-alcoholic fatty liver disease (NAFLD) among the ethnic Kirghiz adult in Xinjiang Province. Methods The study was conducted based on the national health checkup in Xinjiang province during 2018. A total of 19 843 participants of Kirghiz adults in Aheqi County, Xinjiang Uygor Autonomous Region were selected for physical examination, questionnaires, blood biochemical indicators detection (FBG, TG, LDL-C, HDL-C, TC, ALT and AST) and abdominal ultrasonography. A total of 1 396 patients diagnosed with NAFLD by abdominal ultrasonography were selected as the case group, and 4 188 non-NAFLD subjects matched in age, sex and region were selected as the control group at a ratio of 1:3. The clinical characters and risk factors of NAFLD patients were analyzed. Results The overall prevalence of NALFD in Kirghiz adults was 7.0%, 7.8% in male, and 6.2% in female (standardized to 6.8%, 7.5%, and 6.0%, respectively). The prevalence in male was higher than that in female (P<0.01). The prevalence of NAFLD in the obesity, diabetes, and hypertension group was significantly increased, which was 19.0%, 20.6% and 18.5%, respectively. Body mass index (BMI), waist circumference (WC), triglycerides, AST (aspartate aminotransferase) and ALT (alanine transamilase) in the NAFLD group were all higher than those in the control group (all P < 0.01). In the NAFLD group, 17.2% had another one metabolic disorder and 62.0% had another two metabolic disorders. Logistic regression analysis showed that waist circumference (OR = 4.08, 95%CI = 3.04~5.10), FBG (OR = 3.76, 95%CI = 2.86~4.93) and BMI (OR = 3.32, 95%CI = 2.16~4.38) were the main independent risk factors for NAFLD. Literacy (OR = 0.42, 95%CI = 0.24~0.69) and physical activity (OR = 0.68, 95%CI = 0.45~0.96) were protective factors. Conclusion The prevalence of NAFLD in Kirgiz adults in Xinjiang is lower than the national average. More than half of NAFLD patients are comorbidity with at least two metabolic abnormalities. WC, FBG and BMI were the independent risk factors for NAFLD, however, literacy and physical activity were protective factors.