Objective To explore the influencing factors of recurrence and metastasis of gastric cancer after radical operation.Methods The recurrence and metastasis status of 50 patients with gastric cancer underwent the radical gastrectomy were retrospectively analyzed.Logistic multiple regression was used for univariate regression analysis or multivariate regression analysis.Results The average time of recurrence was 18.4 months in 50 cases with gastric cancer after radical operation; The rate of recurrence was 14 cases (28.0%)、12 cases (24.0% )、15 cases (30.0% )、6 cases (12.0% )、3 cases (6.0% ) within six months ,0.5-1 year、1～2 years、2～3 years >more than 3 years respectively; The early recurrence in 41 cases (82.0% ) were significantly higher than the late recurrence of 9 cases (18.0%) (X2 = 6.45,P <0.01) ;The univariate regression analysis indicated that original tumor site.,tumor size,TNM stage、 degree of differentiation,Bomnann classification were influencing factors of recurrence and metastasis (P <0.01); Logistic regression multivariate analysis showed tumor size、pathological TNM staging and adjuvant chemotherapy in gastric cancer were the independent influencing factors (P<0.01).Conclusion Most recurrences would happen within 2 years after radical resection for gastric carcinoma;The tumor size、 tunior pathological stages and adjuvant chemotherapy extent were independent correlation factors of locally recurrent gastric carcinoma.

Multidrug efflux pump is the main reason for bacterial multidrug resistance, and it’s a chal- lenge for the treatment of infectious diseases. Analysis of multidrug efflux pump offers us the mecha- nism and treatment ideas of bacterial multidrug resistance. New advances have been made in the study of Escherichia coli AcrAB-TolC efflux pump structure and its regulation, which provides data for the multidrug resistance research in pathogenic bacterium. Progress in this area is reviewed here.

Peace Ark Hospital Ship of China and Mercy Hospital Ship of U.S.had their current statuses introduced,and then were compared from the aspects of technical parameter,personnel allocation,running mode and etc.The advantages of Mercy Hospital Ship were described in safety,details and rationality.It's pointed out the hospital ship in China minimize cost of medical resources,optimize medical treatment and nursing as well as maximize medical efficacy.

Using “glaucoma” as an experimental curriculum,we focused on the teaching reform of the combination of online courses and classroom teaching.The important change was PBL ( problem based learning ). We wanted to change the traditional teacher-centered teaching model and help the students to change from passive learning to active learning. On the other hand we wanted to enhance the classroom learning effect by using the “problem” “discussion” “interactive” teaching ways.We used this teaching model in the large class courses for eight-year implementation of 2007 undergraduate.The evaluation of feedback was very satisfactory.

Objective To compare advantages and disadvantages of ceramic crown and porcelain fused to metal(PFM),provide better rehabilitation ways for patients.Methods 258 porcelains were,divided into two groups:ceramic crown group 98 and metal ceramic crowns group 160,for preparation of abutment,modulus,colorimetric,feed production.Results Follow-up observation for 2 years,the 15 crowns of all appeared the gingival edge coloring with different degree,are PFM,10 patients were not satisfied with the color of restorations.8 repair body porcelain.Conclusion Inner crown metal of PFM is thin and light,with high hardness and compressive strength.It rarely occur deformation since repeated the barbecue at high temperatures,so suitable for large span bridge restoration.Ceramic crown because of no metal structure,good light transmission and light reflecting function,can reproduce the natural teeth translucent depth and color depth,strong sense of hierarchy,suitable for the repair of anterior teeth.

ObjectiveTo investigate the influence of root resorption caused by orthodontic tooth movement,on gingival crevicular fluid (GCF) dentin sialophosphoprotein,DSPP,dentin sialoprotein,DSP expression.Methods67 patients admitted to hospital orthodontic patients as the clinical study,and according to different power values were divided into experimental group and control group,which had great value for the experimental group(300g) group and control group value for the normal force(30g) group,the two groups one week 12 weeks of its GCF DSPP,DSP expression were detected.ResultsIn the observation group DSPP,DSP expression was significantly higher than that in the control group,two groups of patients were in 7～9 weeks demonstrated increased,the observation group were(232 315 ±5437) gray,(487 876 ± 4374),(287 673 ± 5642),(212 147±2346) control group of gray scale,( 176 565 ±5327),(134 323 ± 2315 );and in 10 weeks after the reduction,the observation group 10 weeks and 11 weeks,(394 532 ± 4326),(287 674 ± 3235 ) ;the control group were( 87 876 ± 4323 ),(76 534 ± 3564),10 week 11 weeks were significantly reduced.ConclusionIn the process of root resorption in GCF DSPP,DSP changes in expression levels may be earlier than the X-ray results and the clinical manifestations,as it may cause root resorption of orthodontic tooth movement in the early detection of a target.

Objective To analyze the clinical efficacy of two different surgical methods in hepatic cystic echinococcosis,and select the better surgical method in curative effect.Methods The clinical data of 120 patients with hepatic cystic echinococcosis were retrospectively analyzed.The patients were divided into outer membrane integrity external capsule excision group and internal capsule excision + external capsule cavity group according to the surgical method with 60 cases each.The operation time,bleeding during operation,hospitalization time,intubation time,complication and recurrence were compared between the 2 groups.Results There was no statistical difference in bleeding during operation between the 2 groups (P＞ 0.05).The operation time in internal capsule excision + external capsule cavity group was shorter than that in outer membrane integrity external capsule excision group [(60.09 ± 9.50) min vs.(110.20 ± 18.50) min],the hospitalization time and intubation time in internal capsule excision + external capsule cavity group were longer than those in outer membrane integrity external capsule excision group [(11.65 ± 3.50) d vs.(7.55 ±1.50) d,(2.55 ± 0.55) months vs.(0.20 ± 0.05) months],there were statistical differences (P ＜ 0.05).The rate of complication and rate of recurrence in internal capsule excision + external capsule cavity group were higher than those in outer membrane integrity external capsule excision group [28.3％ (17/60) vs.3.3％(2/60),25.0％(15/60) vs.1.7％(1/60)],there were statistical differences (P ＜ 0.05).Conclusion The curative effect of outer membrane integrity external capsule excision is better than internal capsule excision + external capsule cavity,and outer membrane integrity external capsule excision is the preferred surgical methods of hepatic cystic echinococcosis.

The teaching mode in ophthalmology has been reformed by giving special subject lessons by different persons.After the reform,there appear the advantages and disadvantages of actual teaching effect.To aim directly at change we propose strengthening the cultivation of young teachers,optimizing the design of teaching content,establishing teaching rules and regulations,introducing PBL(problem based learning)method and stressing evidence-based thinking training.

目的观察护理干预措施对癌症化疗患者呕吐症状的改善情况。方法100例化疗呕吐患者分为试验组和对照组,每组50例。两组均采取临床化疗方案、对症治疗、常规护理,试验组同时给予护理干预。结果在化疗结束时,两组患者的呕吐症状均有减轻,但试验组患者症状改善优于对照组(P<0.05)。结论护理干预能有效减轻癌症化疗患者的呕吐症状。

Mucin antigen 4 (MUC4) is a molecular marker for some malignant tumors for early tumor diagnosis, prognosis and targeted therapy. It provides a new research direction in tumor diagnosis and treatment that will have a wide application prospect. In recent years, there has been a large number of research reports on the basic and clini-a wide application prospect. In recent years, there has been a large number of research reports on the basic and clinical studies about MUC4, but the molecular imaging study about MUC4 is seldom reported. In this paper the recentcal studies about MUC4, but the molecular imaging study about MUC4 is seldom reported. In this paper the recent research about MUC4 on basic and clinical studies is briefly reviewed, and it is expected to promote the development of tumor molecular imaging.
Biomarkers, Tumor ; metabolism ; Early Diagnosis ; Humans ; Mucin-4 ; metabolism ; Neoplasms ; metabolism ; Prognosis