BACKGROUND: Primary multidrug-resistant tuberculosis is defined as Mycobacterium tuberculosis isolates that are resistant to at least isoniazid and rifampin in never-been-treated tuberculosis patients, and this malady is caused by the transmission of a resistant strain from one patient, who is infected with a resistant Mycobacterium tuberculosis strain, to another patient. The prevalence of primary multidrug-resistant tuberculosis could be a good indicator of the performance of tuberculosis control programs in recent years. We conducted a case-control study to identify the risk factors for primary multidrug-resistant tuberculosis. METHODS: From January 1, 2001 to, June 30, 2003, by conducting prospective laboratory-based surveillance, we identified 29 hospitalized patients with P-MDRTB and these patients constituted a case group in this study. The controls were represented by all the patients with culture-confirmed drug susceptible tuberculosis who were admitted to National Masan Hospital during the same study period. The odds ratios for the patients with primary multidrug-resistant tuberculosis, as compared with those of the patients with drug susceptible tuberculosis, were calculated for each categorical variable with 95% confidence intervals. RESULTS: Multivariate logistic regression showed that the presence of diabetes mellitus (odds ratio 2.68; 95% confidence interval, 1.05-6.86) was independently associated with having primary multidrug-resistant tuberculosis. CONCLUSION: This study has shown that diabetes mellitus might be one of the risk factors for primary multidrug-resistant tuberculosis.
Case-Control Studies ; Diabetes Mellitus ; Drug Resistance ; Humans ; Isoniazid ; Logistic Models ; Mycobacterium tuberculosis ; Odds Ratio ; Prevalence ; Prospective Studies ; Rifampin ; Risk Factors* ; Tuberculosis* ; Tuberculosis, Multidrug-Resistant

No abstract available.
Darier Disease*

PURPOSE: The purpose of this study was to determine gender differences in attitudes towards sleeping in separate rooms (SSR) a means of dealing with marital conflict and to explore the reasons why participants agreed or disagreed with SSR. MATERIALS AND METHODS: Research participants were 616 married people (300 men, 316 women) aged 30 to 89 years and currently lived with their spouses in the same house. They were asked to assess their attitudes towards SSR using a Likert scale from 0 (strongly disagree) to 10 (strongly agree). Two separate SSR questions were given to them: one for the respondents themselves and the other for couples in general. RESULTS: There were significant gender differences in attitudes towards SSR. Men generally disagreed with SSR, with a negligible difference between the two separate SSR cases (p>.05). However, women agreed with SSR, especially with the question about the respondents themselves (p<.01). The most frequent reason from agreeing with SSR was to alleviate conflict, while the most frequent reason for disagreeing was related to sexual issues, which showed significant gender differences. CONCLUSIONS: Gender differences in attitudes towards the SSR were found, and the differences were examined in the context of social exchange theory. The limitation of this study was that the sexual interactive and communicative patterns of the couples who were sleeping in separate rooms were not explored.
Aged ; Surveys and Questionnaires ; Family Characteristics ; Family Conflict ; Female ; Humans ; Male ; Spouses

Purpose: For this study the effect of skin disinfection according to the disinfection frequency in peripheral intravenous therapy was examined. Methods: One hundred and twenty skin disinfections, three sections on the right forearm and three sections on the left forearm, were performed on each of 20 seniors in the school of nursing, and 240 microbial cultures were performed before and after the skin disinfection at each site. Single-use sterile packaged 83% alcohol cotton was used to disinfect. The skin was disinfected once, twice, or three times for 5 seconds per session and then allowed to dry for one minute. The data were analyzed using the Kruskal-Wallis test and the Generalized Estimation Equation (GEE). Results: There was no significant difference in the number of microbial colonies by the number of disinfections (p=.599) as well as the number of microbial colonies among those disinfected the same number of times (p=.440). However, the number of microbial colonies after disinfection was significantly lower than that before disinfection (p<.001). The interaction effect, which was the difference in the decrease of microbial colonies by the number of disinfections, was not significant (p=.101). Conclusion Prior to peripheral intravenous injection, disinfecting the skin once for five seconds with an 83% alcohol swab was as effective as disinfecting it twice for 10 seconds or three times for 15 seconds. Therefore, disinfecting the skin thoroughly for 5 seconds or more with an 83% alcohol cotton swab is sufficient for peripheral vein injections in the clinical field.

OBJECTIVES: Effects of nanoparticles including zinc oxide nanoparticles, titanium oxide nanoparticles, and their mixtures on skin corrosion and irritation were investigated by using in vitro 3D human skin models (KeraSkin(TM)) and the results were compared to those of an in vivo animal test. METHODS: Skin models were incubated with nanoparticles for a definite time period and cell viability was measured by the 3-(4, 5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide method. Skin corrosion and irritation were identified by the decreased viability based on the pre-determined threshold. RESULTS: Cell viability after exposure to nanomaterial was not decreased to the pre-determined threshold level, which was 15% after 60 minutes exposure in corrosion test and 50% after 45 minutes exposure in the irritation test. IL-1alpha release and histopathological findings support the results of cell viability test. In vivo test using rabbits also showed non-corrosive and non-irritant results. CONCLUSIONS: The findings provide the evidence that zinc oxide nanoparticles, titanium oxide nanoparticles and their mixture are 'non corrosive' and 'non-irritant' to the human skin by a globally harmonized classification system. In vivo test using animals can be replaced by an alternative in vitro test.
Animals ; Cell Survival ; Classification ; Corrosion* ; Humans ; Nanoparticles* ; Nanostructures ; Rabbits ; Skin* ; Titanium ; Zinc Oxide

PURPOSE: This study was done to evaluate the adequacy of nurse staffing in integrated nursing care. METHODS: Statistical data on integrated nursing care from the National Health Insurance Corporation was used in this study. We extracted hospital data and patient data related to patient needs for nursing care. We analyzed the differences in patient needs by staffing level of each type of medical institution. RESULTS: Approximately 70% of medical institutions provided nursing care by the mid level of nurse staffing, which was 1:6, 1:10 and 1:12 in the tertiary hospital, general hospital and semi-hospital, respectively. The patients' characteristics were significantly different by hospital type. Especially, the distribution of the main diagnosis was completely different between the tertiary hospital and semi-hospital. In the tertiary hospital, the patient needs measured by severity and activities of daily living dependency were higher at higher staffing level than at lower staffing level. However, the nurse staffing was less relevant to the patient needs in the general hospital and semi-hospital. CONCLUSION: To provide high-quality nursing care, accurate workload forecasting is required at the start, and then the standard nurse staffing level can established based on workload forecasting.
Activities of Daily Living ; Diagnosis ; Forecasting ; Hospitals, General ; Humans ; National Health Programs ; Nursing Care ; Nursing ; Tertiary Care Centers

PURPOSE: Automated peritoneal dialysis (APD) is increasingly used due to freedom from daytime exchanges and flexibility of prescription. In this study, we compared APD with continuous ambulatory peritoneal dialysis (CAPD) to assess the influence of mode of PD on various measures of clinical performance. METHODS: We followed 26 APD patients prospectively over a 12-month period and compared them with 16 CAPD patients in whom examinations of dialysis dose and residual renal function (RRF) at least twice during the 1st one year after dialysis were done. Weekly Kt/V urea (Kt/V) and standard creatinine clearance (SCCr) of PD, and RRF (24hr urine creatinine clearance) were measured at 1st month, 6th month and 12th month after start of dialysis. In addition, serial biochemical tests were analyzed every three months during this period. RESULTS: No statistically significant differences in baseline characteristics, RRF, SCCr and Kt/V were observed between APD and CAPD patients. Serum concentrations of bicarbonate, hemoglobin, and calcium tended to be higher in the APD group and actually serum bicarbonate levels at 9 months, calcium levels at 12 months and hemoglobin levels at 6 and 9 months were significantly higher in APD patients (p<0.05). There was no significant difference in serum sodium concentrations and peritonitis rate between the two groups. CONCLUSION: No significant differences were observed between APD and CAPD in Kt/V, SCCr and RRF for one year after start of PD. APD, however, may be advantageous in improving several biochemical markers such as blood levels of hemoglobin, bicarbonate, and calcium compared to CAPD.
Biochemistry ; Biomarkers ; Calcium ; Creatinine ; Dialysis ; Diphosphonates ; Freedom ; Hemoglobins ; Humans ; Peritoneal Dialysis ; Peritoneal Dialysis, Continuous Ambulatory ; Peritonitis ; Pliability ; Prescriptions ; Prospective Studies ; Sodium ; Urea

PURPOSE: This study compared climacteric symptoms, knowledge of menopause and menopausal management of middle aged women living in urban and rural areas. METHOD: The study subjects included 287 women aged 40-64 years in P city and G town. The instruments used in this study were a climacteric symptoms scale and knowledge of menopause and a menopausal management scale. Data was analyzed with SPSS Win 10.0. RESULT: The mean age of middle-aged women living in urban areas was 47.9 years and that of women in rural areas was 48.0 years. The mean score of the climacteric symptoms of middle-aged women living in urban and rural areas was 48.8 and 50.4 respectively, and was not significantly different. The mean score of the knowledge of menopause of middle-aged women living in urban areas was higher than that of women in rural areas (p=.017). In addition, the mean score of the menopausal management of middle-aged women living in rural areas was higher than that of women in urban areas. CONCLUSION: This study suggests that not only general characteristics but also living areas should be considered in developing nursing interventions to manage the climacteric symptoms of middle aged women.
Climacteric* ; Female ; Humans ; Menopause* ; Middle Aged* ; Nursing

Objectives: ：This study looked at the effects of chronic IPV on suicide ideation among married women in the country. Methods: ：This study used data from the five-year-old Korea Welfare Panel and analyzed using questions about verbal and physical violence, depression and suicide ideation that were investigated every year. Age, education, and economic levels, drinking, religion, chronic disease, satisfaction with family relationship, satisfaction with social relationship, were included as variables. Results: ：The five-year cumulative score of verbal violence had a statistically significant effect on the depres-sive symptom, and the relative risk was 1.180. The relative risk of five-year-old cumulative score of verbal violence in suicidal ideation was 1.276, and it was also significant even if they exclude the effects of depressive symptom.On the other hand, the five-year cumulative score of physical violence was found to have no significant impact on suicide ideation if they excluded the effects of depressive symptom. Conclusions ：Unlike previous studies, this study found that chronic verbal IPVs increase suicide ideation,even though they do not contain effects of depression. Such findings suggest that intervention in IPV in married women may help reduce the nation's suicide rate.

Objectives: ：This study looked at the effects of chronic IPV on suicide ideation among married women in the country. Methods: ：This study used data from the five-year-old Korea Welfare Panel and analyzed using questions about verbal and physical violence, depression and suicide ideation that were investigated every year. Age, education, and economic levels, drinking, religion, chronic disease, satisfaction with family relationship, satisfaction with social relationship, were included as variables. Results: ：The five-year cumulative score of verbal violence had a statistically significant effect on the depres-sive symptom, and the relative risk was 1.180. The relative risk of five-year-old cumulative score of verbal violence in suicidal ideation was 1.276, and it was also significant even if they exclude the effects of depressive symptom.On the other hand, the five-year cumulative score of physical violence was found to have no significant impact on suicide ideation if they excluded the effects of depressive symptom. Conclusions ：Unlike previous studies, this study found that chronic verbal IPVs increase suicide ideation,even though they do not contain effects of depression. Such findings suggest that intervention in IPV in married women may help reduce the nation's suicide rate.