Tumor markers can reflect tumor existence,and open an entrance to diagnose tumor at early stage.Recent researches reveal that gastric cancer related tumor markers such as microRNAs,enzymes,cytokines and antibodies-antigens are significant for the diagnosis,treatment,relapse surveillance,prognosis evaluation of gastric cancer.

0.05), yet it correlated with RE incidence (P2.6 ,high risk ),obesity( OR=1.7～ 2.5,moderate risk ),over ingestion and intake of coffee and sweets ( OR=1.2～ 1.6,low risk ). Conclusion RE is frequently seen in adult population around Xi’ an area with a variety of risk factors.

Objective To design a monitoring system of the state of life for a crew in order to ensure their life safety. Methods A wearable physiological parameter monitoring technology was used, and the fabric electrode and temperature sensors were embedded in the vest.The thress-lead electrode was used to extract ECG and respiration signal,temperature signals were collected with a thermistor of negative temperature parameters.Blood pressure and blood oxygen saturation were detected by a finger cuff type of blood oxygen sensors.The volume pulse wave velocity method was used to extract blood pressure signals,and the photoelectric measurement method was used to extract blood oxygen saturation signals.The state of life was evaluated by calculation of the times of respiration and divided into 4 states.Results and Conclusion The system is capable of low load dynamic monitoring of physiological parameters of a crew and evaluation of their state of life, contributing much to self-aid and buddy aid among the crew.

Objective To explore the effects of infrasound frequency and intensity on gastric emptying in rats. Methods One hundred and forty rats were randomly divided into a control group, and groups receiving 8 Hz-90 dB, 8 Hz-130 dB and 16 Hz-130 dB infrasound. Another 70 rats were randomly divided into a control group and an exposure group continuously stimulated with infrasound at 8 Hz and 130 dB. The control group again was not exposed. The gastric emptying rate of the rats in all the groups was tested at different time points. Results ①Compared with the control group, gastric emptying rate decreased significantly after exposure to infrasound for 7 or 14 days. After exposure for 1 day, no significant difference was found. After exposure for 7 , 14, 21 or 28 days, gastric emptying decreased significantly more in the 8 Hz-130 dB group than in the 8 Hz-90 dB group or the control group. ②Compared with the controls, gastric emptying decreased in the 16 Hz-130 dB group after exposure for 1 , 7 and 14 days, but there was no significant difference between these two groups after 21 or 28 days. Gastric emptying decreased significantly more at 8 Hz-130 dB than at 16 Hz-130 dB after exposure for 14 or 28 days.③Gastric emptying tended to recover after exposure of 14 days to 8 Hz-130 dB infrasound, but compared with the controls, gastric emptying was still reduced after exposure had been stopped for 1 , 7 , 14, 21 and 28 days. Conclusion Infrasound at 8 Hz-90 dB, 8 Hz-130 dB or 16 Hz-130 dB can restrain stomach emptying. The extent of the reduction is closely related to the frequency, intensity and exposure time. Gastric emptying tends to recover after infra-sound exposure is stopped.

Objective To observe the effects of infrasound on the expression of inducible nitric oxide synthase(iNOS)and endothelial nitric oxide synthase(eNOS)in gastric tissues in rats.Methods The study consisted of a total of 210 SD rats.Of them,140 rats were randomly divided into 8 Hz-90 dB,8 Hz-130 dB and 16 Hz-130 dB experimental groups and a control group A.The experimental groups were exposed to infrasound with different frequencies and intensities,2h/d.After exposure for 1,7,14,21 and 28 days,7 rats randomly selected from each group underwent an examination of the expression of iNOS and eNOS in gastric tissues.The other 70 rats were randomly divided into a control group B and an exposure group continuously stimulated by infrasound with 8 Hz-130 dB for 14 days,2 h/d,and after stopping exposure for 1,7,14,21 and 28 days;the same indexes were detected in 7 rats randomly selected from each group.Results ① Compared with that in the control group A,the expression of iNOS in gastric tissues significantly increased in 8 Hz-90 dB group after exposure for 14 and 21 days,in 8 Hz-130 dB group after exposure for 7,14,21 and 28 days and in 16 Hz-130 dB group after exposure for 7 and 14 days(P

OBJECTIVETo observe the clinical effect of chronic fatigue syndrome (CFS) treated with moxibustion at Gaohuang (BL 43).

METHODSWith stratified block randomization, 72 patients accorded with inclusive criteria were divided into a moxibustion at Gaohuang (BL 43) group (moxibustion group) and an acupuncture group, 36 cases in each one. In the moxibustion group, Gaohuang (BL 43) was treated with big moxa cones as the main acupoint, 10 cones a time; Qihai (CV 6) and Zusanli (ST 36) were added with big moxa cones, 7 cones a time. In the acupuncture group, acupoints were the same as those in the moxibustion group, and twirling reinforcing method was used after qi arriving, 60 times one minute and 360° with range. In the two groups, 10-day treatment was made into one course and there were two days between courses. The treatment was given once a day for 3 courses. Changes of fatigue assessment index (FAI) before and after treatment and clinical effects were observed.

RESULTSThe total effective rate was 88.9% (32/36) in the moxibustion group, which was better than 72.2% (26/36) in the acupuncture group apparently (P < 0.05). After treatment in the two groups, FAI scores were obviously declined compared with those before treatment (both P < 0.01) and FAI score in the moxibustion group was apparently lower than that in the acupuncture group (P < 0.05).

CONCLUSIONMoxibustion at Gaohuang (BL 43) can improve the FAI score of patients with CFS and the clinical efficacy is definite.

Acupuncture Points ; Adult ; Fatigue Syndrome, Chronic ; therapy ; Female ; Humans ; Male ; Middle Aged ; Moxibustion ; Treatment Outcome ; Young Adult

Objective: To investigate the clinicopathological features, treatment and prognosis of duodenal-type follicular lymphoma. Methods: Four cases of duodenal-type follicular lymphoma diagnosed at Guangdong General Hospital from 2014 to 2015 with detailed clinical data were included. The histomorphology, immunophenotype, treatment and prognoses were analyzed. Results: The patients′ age ranged from 51 to 57 years (mean 54 years), and there were 2 males and 2 females. The involved sites were gastric fundus in one case, second portion of the duodenum in two cases and terminal ileum in one case. All patients presented with multiple mucosal granules or nodules at endoscopy. Microscopically, there were multiple mucosal neoplastic follicles, constituting grade 1-2 disease based on nodal follicular lymphoma grading system. The tumor cells were positive for CD20, CD10, bcl-6 and bcl-2. CD21 highlighted the follicular dendritic meshwork mainly at the periphery of the follicles. Proliferation index was low. Three patients received rituximab monotherapy for 4 cycles, leading to complete remission. One patient refused therapy and the disease progressed to systemic lymphoma 15 months after the initial diagnosis. Conclusions Duodenal-type follicular lymphoma is a special variant of follicular lymphoma with indolent clinical course. The tumor exhibits morphology of low grade follicular lymphoma with characteristic dendritic meshwork at the periphery of the follicles and a low proliferation index. Prognosis is excellent. Rituximab monotherapy is treatment of choice, but a small minority of patients may progress to systemic disease.

Objective: To investigate MAML2 gene-translocation in primary pulmonary mucoepidermoid carcinoma (PMEC) and pulmanary adenosquamous carcinoma, and the optimal diagnostic immunohistiochemical (IHC) panel in distinguishing PMEC from adenosqumous carcinoma. Methods: Twenty-four cases of PMEC and 44 adenosqumous carcinoma diagnosed in the Guangdong General Hospital were tested for MAML2 translocation by fluorescent in-situ hybridization (FISH) using tissue array. An IHC panel including TTF1, Napsin A, CK5/6, p63, p40 and Ki-67 was performed on the cohort. The clinical data for all cases were collected and all PMEC patients had follow-up information. Results: The patients′ age ranged form 6 to 73 years, with a median age of 32 years. The male to female ratio was 1.4∶1.0. MAML2 translocation was found in 16/24 (66.7%) cases of PMEC whereas all 44 cases adenosqumous carcinoma were negative for translocation. All the cases of the PMEC were negative for TTF1 and Napsin A but positive for CK5/6, p63 and p40 in the intermediate cells and epidermal-like cells. In most PMEC cases, the Ki-67 expression index was lower than 10%. In contrast, most cases of adenosqumous carcinomas expressed TTF1 and Napsin A in the adenomatous component and CK5/6, p63 and p40 in the squamous component, which expression pattern was different from that of PMEC. Based on IHC staining, 2 cases of highly invasive ALK-positive adenocarcinoma mimicing PMEC were also found in the study. Conclusions MAML2 gene translocation can be detected in about two-third of PMEC. Translocation of MAML2 gene and lower morphology grading are associated with good prognosis. The combined use of IHC antibodies panel is helpful to distinguish PMEC from the adenosqumous carcinoma and adenocarcinoma mimicing PMEC.

Visually impaired people face many inconveniences because of the loss of vision. Therefore, scientists are trying to design various guidance systems for improving the lives of the blind. Based on sensory substitution, auditory guidance has become an interesting topic in the field of biomedical engineering. In this paper, we made a state-of-technique review of the auditory guidance system. Although there have been many technical challenges, the auditory guidance system would be a useful alternative for the visually impaired people.
Acoustics ; Auditory Perception ; Biomedical Engineering ; Equipment Design ; Humans ; Sensory Aids ; Software ; Sound Localization ; Visual Perception ; Visually Impaired Persons ; rehabilitation