Objective To study the effects of labor analgesia on maternal and newborn. Methods A total of 3154 clinical cases of monotocous, primiparous, head delivery and full term pregnant women delivered in our hospital from June 2012 to June 2014 were reviewed and analyzed , where there were 197 cases to be used the labor analgesia. 150 cases with labor analgesia among them were selected randomly as the experiment group, and other 150 cases without labor analge si a in the same time and conditions were selected as control group. The differences on degree of labor pain, time of labor, 1-minute and 5-minute’s Apgar scores of newborn, amount of bleeding of 2 hours after delivery and rate of cesarean section between experiment group and control group were compared by t-test or chi-square test methods. Results Analgesic effect in test group was statistically better than control group (P=0.000);There were not sta-tistical differences between test group and control group in the second labor time (P=0.191),but there were statistically significant differences in the first labor time,the third labor time and total labor time(P=0.000, 0.000, 0.000). There were not statistical differences between two groups newborns in 1 minute and 5 minute ’s Apgar scores of newborn , amount of bleeding of 2 hours after delivery (P=0.785,0.770,0.541). The rate of cesarean section was obviously lower in test group than in control group and it was statistical significance(P=0.000). Conclusion Pain in labor can be obviously reduced by using labor analgesia , and the rate of cesarean section also can drop down dramatically , fur-thermore, it has no bad effect on maternal and newborn health. Therefore, labor analgesia is worth of being generalized.