A total of 123 type 2 diabetics was randomised into 3 groups to receive gliclazide-MR, gliclazide or glibenclamide treatments for 16 weeks.All the subjects took self-monitoring of blood glucose (SMBG) during the trial.The effect of therapy was similar in 3 groups.The subtraction value between maximum and minimum blood glucose, mean postprandial maximum blood glucose, postprandial 2 h blood glucose, postprandial 2 h serum insulin and hypoglycaemia events were lower in gliclazide-MR group than those in glibenclamide group (all P＜0.01).The data suggest that SMBG is an useful method to evaluate blood glucose excursion.

Objective Toinvestigatethevalueof"blendsign"onCTtopredictearlyhaematomaexpansioninacuteintracerebral haemorrhage(ICH).Methods SeventyGninepatientswithacuteICH whounderwentbaselineCTscanwithin6hourswereenrolled retrospectively.TheywerealsorecheckedwithCTscanin24hours.Allpatientsweredividedintoearlyhaematomaexpansiongroup and nonGhae m ato m a expansion group according to the change of hae m orrhage volu m e.M ultivariable L o g istic regression analysis w as usedtodetermineindependentriskfactorsofearlyhaematomaexpansion.Results Therewere28cases (35.4%)withhaematoma expansionin79patients."Blendsign"wasobservedin23patientsonbaselineCTscan,16of23 (69.6%)patientsappearedhaematoma expansion.Thesensitivity,specificity,positivepredictivevalue,negativepredictivevalueof"blendsign"forpredictingearlyhaematoma expansion w ere 57.1%,86.2%,69.6%,78.6%.M ultivariable L o g istic regression analysis sho w ed baseline hae m orrhage volu m e and"blendsign"wereindependentlyassociatedwithhaematomaexpansion.Conclusion "Blendsign"canbeusedtopredicthematoma expansioninacuteICH,whichishelpfultoidentifyhighriskpatientswithearlyhaematomaexpansiontomakethetreatmentmore promptlyandaccurately.

Objective To understand correlation between maternal drug use and environmental exposure during pregnancy and delivery pattern and allergy in infants and toddlers,and provide theoretical bases for the early prevention and intervention of infantile allergies.Methods Case control study based on cross-sectional investigation was conducted.Thirty-three cities were selected in China.Randomly cluster sampling method was used to select a community in each city as the study sample,the women with infants aged 0-24 months were interviewed in the form of face-to-face questionnaire survey.Infants and toddlers were divided into two groups:case group,including 2113children who had allergic symptoms and were diagnosed with allergic disease,and control group,including 6303 children who never had symptoms of allergic disease.Results Children whose parents had allergic disease histories were more likely to have allergic disease (OR=3.950) compared with the children whose mother or father had allergic disease histories (0R=2.277).Maternal use of antibiotics (OR=1.396),disinfector exposure (0R=1.386),smoking exposure (OR=1.301) during pregnancy and cesarean delivery (OR=1.255) were risk factors for allergic disease in infants and toddlers,the differences were significant (P＜0.05).Conclusion It is essential to conduct primary prevention of infant allergy during pregnancy,and it is necessary to avoid unnecessary cesarean delivery and irrational antibiotic use,disinfector and smoking exposures during pregnancy.

Objective:To explore the nursing characteristics of patients with atrial fibrillation in "zero ray" transcatheter radiofrequency ablation, and to analyze the postoperative surgical indexes, nursing indexes and anxiety level.Methods:A total of 127 patients who underwent radiofrequency ablation of atrial fibrillation in Xuanwu Hospital, Capital Medical University from October 2018 to September 2020 were divided into the control group ( n=64) and the observation group ( n=63) by random number table method. Patients in the control group received conventional radiofrequency ablation for atrial fibrillation and received conventional nursing care. The observation group made full use of the advantages of the three-dimensional mapping system, using "zero-ray" green electrophysiological technology to complete the intervention of the control group, and parallel personalized nursing intervention measures. The operative indexes, nursing indexes, anxiety and pain levels of 2 groups were compared. Results:The ablation time, total operation time in the control group were (1 917.38±157.74) s, (110.32 ± 35.83) min, respectively, and those in the observation group were (1 915.87±87.19) s, (109.45 ± 28.92) min, and the difference between the two groups was statistically significant ( t value was 1.201, 0.150, P>0.05). The nursing satisfaction score, the time spent with nurses, and the awareness rate of education in the control group were (90.00±3.00) points, (30.36±7.58) min, 68.75%(44/64), respectively, and those in the observation group were (95.00±5.00) points, (40.27±10.68) min, 85.71%(54/63), the difference between the two groups was statistically significant ( t value was -6.845, -6.037, χ2 value was 5.185, all P<0.05). The anxiety score and pain score in the control group were 10.42±2.54 and 7.34±1.55, respectively, and those in the observation group were 6.34±1.21 and 4.64±0.92, respectively. The difference between the two groups was statistically significant ( t value was 11.526, 11.913, both P<0.01). Conclusions:Green electrophysiology transcatheter radiofrequency ablation is a safe, effective and feasible method, and the nursing satisfaction is improved.