Objective To discuss the application effect of clinical nursing pathway of Traditional Chinese Medicine ( TCM) in facial paralysis patients. Methods A total of 80 cases of facial paralysis patients from February 2012 to August 2014 were randomly divided into the observation group ( n=40 ) and the control group (n=40) according to random number table method. The control group was adopted routine treatment and nursing care, while the observation group was given clinical nursing pathway of TCM treatment and nursing care. The average length of hospital stay, hospital expenses, nursing compliance and satisfaction were compared. Results The hospitalization time and cost of the observation group were (13 ± 2. 3) days and (7 382. 0 ± 123. 1) yuan, which were significantly better than those of the control group (t=10. 70, 39. 55, respectively;P<0. 05). In the observation group, 36 patients were totally complied, three patients were partially complied, and one patient was not complied, which were significantly better than those of the control group (Z=4. 96,P<0. 05). In the observation group, 37 patients were totally satisfied, three patients were basically satisfied, and no patient was not satisfied, which were significantly better than those of the control group (Z =4. 97,P <0. 05). Conclusions The application of TCM clinical nursing pathway in facial paralysis patients can reduce the length of hospital stay and hospital costs, and improve patients′care compliance and satisfaction.