The bony part of the external nose was observed and measured in 150 Chinese adult skulls (male 100, female 50), The results are as follows.1. The nasion consists of the upper end of the nasal bone and the nasal part of the frontal bone. It is the anterior wall of the frontonasal canal. The average thickness of this wall is 8.08?0.11 mm.2. Features of the nasal bone: 144 cases (288 sides, 96.00％) are oblong and 4 cases (8 sides, 2.67％) are triangular in shape, in 2 cases (4 sides, 1.33％) the right sides are oblong and the left sides are triangular in shape. The length, width and thickness of the nasal bone were measured.3. The frontal process of the maxilla, according to the feature and clinical importance of the topographical characteristics, can be divided into upper, middle and lower portions. (1) The upper portion is a somewhat flat bony process, its anterior surface is flat and posterior surface is rough, which related to the ethmoid cell closely. The average width and thickness of this portion are 8.45?0.06mm and 5.72?0.09mm respectively. (2) The middle portion is the surgical area of the nasolacrimal fistulation. The average width of the part anterior to the anterior lacrimal crest (nasal part) is 6.77?0.05mm; and the average width of the part posterior to the crest (lacrimal part) is 4.97?0.04mm. The average thickness of the middle point of the anterior lacrimal crest is 4.68?0.08mm. (3) The lower portion is the transitional area of the frontal process and the corpus of the maxilla. It is a three-facet pyramid with an obtuse sulcus on its anterior lateral surface the nasofacial sulcus, which is the landmark between the external nose and face. The average width from the lower end of the nasomaxillary suture to the bottom of the sulcus is 8.16?0.04mm. The average thickness is 1.70?0.02mm.4. The margin of the piriform aperture: (a) The upper part of the margin formed by the lower border of the nasal bone, the upper border of the upper lateral cartilage of the nose digs behind it and joins each other by a syndesmosis; (b) the width of the lateral part of this margin was measured from the free border of the margin to the anterior end of the inferior turbinate, the average width is 2.62?0.07mm; (c) the lower margin of the piriform aperture and the anterior nasal spine, according to the anthropological classification, were observed and their clinical significance were discussed.

The cartilaginous external nose was observed and measured in a total of 66 adult Chinese cadavers (male 86 sides, female 45 sides). In 57 cases (114 sides) the anatomical method was used and in the remaining 9cases (17 sides), the cartilaginous external nose was removed from the cadaver, embedded in celloidin, and cut into serial coronary sections. Each section was 50～80 ?m in thickness, stained with hematoxylin-eosin and examined microscopically. The following observations were made.1. The morphology and interdigitatum of the nasal cartilage were observed.2. The size of the lateral crus of the cartilago alaris major: The average cephalocaudal length is 9.72?0.11 mm; the average medio-lateral length is 13.51?0.10mm; the average length of the inferior border is 9.36?0.13 mm. 3. The average distance from the middle line to the contact point of the cartilago nasi lateralis and the cartilago alaris major is 3.0?0.11 mm.4. The average distance from the inferior border of the cartilago alaris major to the edge of the alae nasi is 5.01?0.07mm.5. The average angle of rise of cartilago alaris major from cartilago nasi lateralis (cephalocaudad) is 23.06?.6. The interdigitation between cartilago nasi lateralis and eartilago alaris major were classified into the following three types: a) interlocked scroll(82 sides, 62.6％?4.23), b) overlap only (24 sides, 18.32％?3.38) and end-to-end (25 sides, 19.55％?3.34).7. According to applied surgical anatomy, the wall of the cartilaginous external nose can be divided into 4 layers: a) the mucoperichondrium, b) the cartilage, c) the subcutaneous muscular layer and d) the skin.8. Age changes in the configuration of the cartilaginous external nose and the cartilaginous support of the nasal tip were observed and discussed.

BACKGROUND: Whole body vibration (WBV) training has gained increased attention at the beginning of 21st century as a sort of exercise. WBV instruments are popularized gradually; in the meanwhile, WBV training has showed its values especially for people who are too feeble to attend conventional exercises, among whom, the elderly accounts a lot.OBJECTIVE: To summarize the effects of WBV training on low extremity functions and chronic diseases in older individuals, and to explore the underlying mechanism, thus providing reference for the study on WBV training.METHODS: Web of Science, PubMed and CNKI databases were searched for the literatures addressing WBV training published between 1998 and 2015 with the subject word of whole body vibration and the keywords of older adult, elderly,seniors, aging in English and Chinese, respectively. The articles related to the lung diseases were excluded. The subjects were more than 60 years old, the low extremity functions included neuromuscular function, balance and walking abilities, and the chronic diseases included stroke, type 2 diabetes mellitus, hypertension and Parkinson disease.RESULTS AND CONCLUSION: WBV training is likely to increase muscle strength, body balance and functional mobility.In terms of chronic diseases, WBV training contributes to muscle strength, relieving muscle stiffness, amyostasia,enancing improving some indexes of chronic diseases. WBV training is a safe and feasible exercising way for elderly people scheduled for improving the muscle strength, balance and walking abilities. Considering the existed evidences,WBV cannot replace the conventional therapy to treat chronic diseases in the elderly. Furthermore, a large number of high quality trials should be conducted in the future to clarify its effectiveness and application values.

Objective To study the mechanism of cytotoxic T lympocytes in the acute rejection of xenogenic liver transplantation(XLT). Methods Hamster to rat orthotopic liver transplantation model was performed with three cuff method. In XLT,lymphocytes including CD8 and CD4 subsets were observed by histology and immunohistochemistry; the expression of perforin and Fas- L was observed by immunohistochemistry; and apoptotic cells of XLT were observed in situ end-labelling of fragmented DNA. Results In the XLT, T cell infiltration firstly ocurred on the 2nd day posttansplantation and located at the portal triads; the infiltrating lymphocytes proliferated increased with time and reached the peak on the 5th to 6th days.Perforin and Fas-ligand were expressed on the 4th day after XLT, and peaked on the 5th to 6th day,and the expression of perforing was still higher than the expression of Fas-ligand. Conclusions T lymphocyte participates in the acute rejection of XLT through the expression of perforin and Fas-ligand, which leads to apoptosis or necrosis of hepatocytes.

Objective To study the occurrence of apoptosis in acute rejection of hamster-to-rat liver transplantation and the molecular mechanism. Methods On the basis of establishment of hamster-to-rat orthotopic liver transplantation, the apoptosis in xenograft were observed by histology and in situ end-lebelling of fragmented DNA;the expression of Fas-L and TGF-?1 were observed by Immunohistochemistry. Rseults In acute rejection of liver xenograft, the apoptosis of hepatocyte was detectable, meanwhile, the expression of Fas-L and TGF-?1 were found. The more severe apoptosis, the more severe acute rejection , and the more expression of Fas-L and TGF-?1 . Conclusions Apoptosis as a mechanism of cell death exists in the acute rejection of liver xenograft, and it is closely related to the expression of TGF-?1 and Fas-L.

BACKGROUND: In China, population aging makes pension become prominent, so different pension patterns haven been developed. However, the existing patterns pay bare attention to the physical exercise of the elderly, and the elderly need regular exercise to delay the aging and improve the quality of life. Vibration training is an exercise method that popularized in the past decade. It can effectively enhance the muscle strength and balance function of the elderly. Little is reported on sitting posture, and exploring the effect of vibration training in sitting position on the elderly provides reference for physical intervention of the elderly. OBJECTIVE: To explore the effect of 12-week vibration training in sitting posture on muscle strength of lower extremity, balance and walking ability of the elderly living in the day-care center. METHODS: Thirty-six elderly with an average age of 82.9 years were randomized into trial (n=20) and control (n=16) groups. The trial group underwent 12-week vibration training in sitting posture (amplitude: 3 mm; frequency: 3-13 Hz; 5 min/set, 1 minute in between; 2-4 sets/session; 3 times/week) by using vibration platform BODYGREEN. The control group received no vibration training in sitting posture with normal rest. Only investigators were blind to grouping. RESULTS AND CONCLUSION: Compared with the baseline, the five times sit to stand test, intensive Romberg test results, time up and go test results and 10-m walking test results showed no significant changes in the trial group. The deviation length, deviation area and Y-axis deviation of eyes open, and the deviation length and Y-axis deviation of eyes closed in Win-Pod balance test were significantly reduced (P ＜ 0.05). The indexes showed no significant changes in the control group before and after training. The elderly had good adaptability to vibration training in sitting posture, with no dizziness or other adverse reactions. These results imply that 12-week vibration training in sitting posture is beneficial to overcome the deviation of the center of gravity in older adults. Nevertheless, the effect of improving muscle strength of lower extremity and walking ability is not obvious. Vibration training in sitting posture can be accepted by the elderly, which may be regarded as a way of daily exercising for older adults.

OBJECTIVETo explore the safety and efficacy of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in preventing chemotherapy-induced neutropenia in patients with breast cancer and non-small cell lung cancer (NSCLC), and to provide the basis for clinical application.

METHODSAccording to the principle of open-label, randomized, parallel-group controlled clinical trial, all patients were randomized by 1∶1∶1 into three groups to receive PEG-rhG-CSF 100 μg/kg, PEG-rhG-CSF 6 mg, or rhG-CSF 5 μg/kg, respectively. The patients with breast cancer received two chemotherapy cycles, and the NSCLC patients received 1-2 cycles of chemotherapy according to their condition. All patients were treated with the combination chemotherapy of TAC (docetaxel+ epirubicin+ cyclophosphamide) or TA (docetaxel+ epirubicin), or the chemotherapy of docetaxel combined with carboplatin, with a 21 day cycle.

RESULTSThe duration of grade 3-4 neutropenia in the PEG-rhG-CSF 100 μg/kg and PEG-rhG-CSF 6 mg groups were similar with that in the rhG-CSF 5 μg/kg group (P>0.05 for all). The incidence rate of grade 3-4 neutropenia in the PEG-rhG-CSF 100 μg/kg group, PEG-rhG-CSF 6 mg group, and G-CSF 5 μg/kg group were 69.7%, 68.4%, and 69.5%, respectively, with a non-significant difference among the three groups (P=0.963). The incidence rate of febrile neutropenia in the PEG-rhG-CSF 100 μg/kg group, PEG-rhG-CSF 6 mg group and G-CSF 5 μg/kg group were 6.1%, 6.4%, and 5.5%, respectively, showing no significant difference among them (P=0.935). The incidence rate of adverse events in the PEG-rhG-CSF 100 μg/kg group, PEG-rhG-CSF 6 mg group and G-CSF 5 μg / kg group were 6.7%, 4.1%, and 5.5%, respectively, showing a non-significant difference among them (P=0.581).

CONCLUSIONSIn patients with breast cancer and non-small cell lung cancer (NSCLC) undergoing TAC/TA chemotherapy, a single 100 μg/kg injection or a single fixed 6 mg dose of PEG-rhG-CSF at 48 hours after chemotherapy show definite therapeutic effect with a low incidence of adverse events and mild adverse reactions. Compared with the continuous daily injection of rhG-CSF 5 μg/kg/d, a single 100 μg/kg injection or a single fixed 6 mg dose of PEG-rhG-CSF has similar effect and is more advantageous in preventing chemotherapy-induced neutropenia.

Antineoplastic Agents ; adverse effects ; therapeutic use ; Antineoplastic Combined Chemotherapy Protocols ; Breast Neoplasms ; drug therapy ; Carboplatin ; administration & dosage ; adverse effects ; Carcinoma, Non-Small-Cell Lung ; drug therapy ; Cyclophosphamide ; administration & dosage ; adverse effects ; Epirubicin ; administration & dosage ; adverse effects ; Female ; Granulocyte Colony-Stimulating Factor ; therapeutic use ; Humans ; Incidence ; Induction Chemotherapy ; Lung Neoplasms ; drug therapy ; Neutropenia ; chemically induced ; epidemiology ; prevention & control ; Polyethylene Glycols ; Recombinant Proteins ; administration & dosage ; Taxoids ; administration & dosage ; adverse effects