Objective To compare the clinical efficacy of low incision thyroidectomy and traditional thyroid surgery in the treatment of thyroid nodules.Methods 84 patients with thyroid nodules were included in the study.According to the order of treatment,42 cases who were compiled as single number were selected as the control group,and they were given traditional thyroid surgical treatment.While 42 cases who were compiled as double number were selected as the observation group,and they were given low incision thyroidectomy.The clinical effects were compared between the two groups.Results The incision length[(3.72±0.59)cm],the intraoperative blood loss[(41.68±3.57)mL],the operation time[(38.27±4.16)min],the hospitalization time[(4.32±1.07)d]in the observation group had statistically significant differences compared with the control group(t=6.886,7.429,7.280,6.775,all P<0.05).The total effective rate in the observation group was 92.86%,which was higher than 73.81% in the control group,the difference was statistically significant(χ2=7.445,P<0.05).The incidence rate of postoperative complications in the observation group was 7.14%,which was lower than 26.19% in the control group,the difference was statistically significant(χ2=8.564,P<0.05).Conclusion Compared with traditional thyroid surgery,the low incision thyroidectomy is effective in the treatment of thyroid nodules,which can reduce the amount of intraoperative blood loss,shorten the operation time and hospitalization time,and has less trauma,quick recovery and low incidence of complication,and it can be used as the first choice for clinical treatment.

Objective To investigate the mechanism of grow-inhibition and apoptosis induced by marine on Hep-2 line. Methods The growth inhibiting rate of matrine on Hep-2 cells was detected by MTT assay. Fluorescence microscope, DNA gel electrophoresis and flow cytometry (FCM) were applied to determine the presence of apoptosis and cell cycle. Results Matrine had cytotoxic effect to Hep-2 cells in a time- and dose-dependent manner. The FCM analysis showed that the number of Hep-2 cells of S phase and the apoptosis rate increased, while the number of G2/M phase decreased. There were morphological changes including chromatin condensation, nuclear fragmentation and apeptotic bodies formed. DNA gel electrophoresis analysis showed typical DNA ladder of apoptosis. Conclusion Matrine inhibits cell prolif-eration by blocking Hep-2 cell cycle to S phase, and exerts its anti-carcinoma function by inducing apoptosis.