1.Progress of cell death induced by Neddylation modification pathway inhibitor MLN4924
Jingrong XIAN ; Shiwen WANG ; Yue LIU ; Yanmei ZHANG ; Hu ZHAO
Cancer Research and Clinic 2021;33(5):393-396
Protein ubiquitin-like modification of Neddylation is an important post-translational modification mode of protein to widely regulate cell cycle, growth, development and other biological processes. Recent studies have found that MLN4924, small molecule inhibitor of Neddylation modification, has a significant anti-tumor effect, which can inhibit the tumor growth by inducing cell cycle arrest, senescence and apoptosis, and inhibiting tumor angiogenesis. This paper reviews the related mechanism research of cell programmed death induced by Neddylation modification pathway inhibitor MLN4924.
2.Research on the anti-lung cancer effects of targeted Neddylation modifying pathway and its inhibitor MLN4924 and its mechanism
Feng ZHU ; Shiwen WANG ; Jingrong XIAN ; Yue LIU ; Hu ZHAO ; Yanmei ZHANG
Journal of International Oncology 2021;48(9):564-567
Neddylation is overactivated in lung cancer, which promotes the development of lung cancer by activating its downstream CRL ubiquitin ligase and promoting the CRL tumor-suppressor protein substrate degradation. MLN4924, a small molecule inhibitor of Neddylation, plays an anti-lung cancer role by inducing cell cycle arrest, apoptosis and senescence. Furthermore, targeting the key enzymes of Neddylation and their substrates, Cullin family proteins, can inhibit the development of lung cancer.