OBJECTIVE To inspect and analyze the cleaning efficacy on surgical instrument after cleaning cycle and maintenance procedures.METHODS The medical instrument was collected from each department based on the weekly usages.Focus on the timing of the cleaning after use and the efficacy of the cleaning methods.Use naked eyes to inspect the cleanness of the medical instrument after each cleaning cycle.RESULTS The combination of the machine washing and manual washing immediately after the surgical procedures provided better cleaning efficacy.It was more difficult to clean the instrument once the dried bio-burden on it or after soaking in the chlorine disinfectant.CONCLUSIONS The correct cleaning methods and instrument care procedures guarantee the cleaning efficacy,disinfections,and the sterilization for the medical instrument.

Objective As there are difficult problems in surgical puncture needle cleaning and cleaning effect monitoring,we are aiming at finding some reliable solutions through relevant comparative tests. Methods Lumbar puncture needle,bone puncture needle and anesthe-sia spinal needle after clinical use,80 of each kind,were randomly collected and equally divided into the experimental group and the control group. The control group was given traditional lumen surgical instruments cleaning procedure,and the experimental group was given newly cre-ated small lumen instruments manual cleaning procedures. Magnifying glass,self-made instruments monitoring and ATP bioluminescence mo-nitoring were respectively used to verify the cleaning effect. Results All needles were monitored with magnifying glass,self-made instruments monitoring and ATP bioluminescence monitoring after cleaning,and the qualified rate were 98. 33%,97. 00% and 93. 33% respectively in the experimental group while 95. 00%,83. 33% and 78. 33% respectively in the control group. Results of self-made instruments monitoring and ATP bioluminescence monitoring showed that there was no difference between the two kinds of detection methods. Conclusion Newly created small lumen instruments manual cleaning procedures and self-made instruments monitoring were of reliable effect and strong operabili-ty in terms of puncture needle cleaning and cleaning effect monitoring,and they were worthy of further research and application.

Objective To investigate and observe the expression of Peroxiredoxin Ⅵ in iechemia cortex of rats and the intervention effect of Xingnao Kaiqiao Acupuncture(XKA) therapy. Methods Through western blotting,we detected the expression of Peroxiredoxin Ⅵ in xingnao kaiqiao group , comparison group, model group and sham operation group in middle cerebral artery occlusion (MCAO)model of rats. Results At 6h, the expression of Peroxiredoxin Ⅵ in xingnao kaiqiao group , comparison group and sham operation group was increased than that in moddle group,of which Xingnao Kaiqiao group increased obviously(P < 0.05). At 24h, as compared with modlegroup, the expression of Peroxiredoxin Ⅵ in xingnao kaiqiao group and comparison group increased significantly (P < 0.05). Conclusion Xingnao Kaiqiao Acupuncture therapy could raise the expression of Peroxiredoxin Ⅵ in focal cerebral ischemia of rats, and the effect is better that of traditional acupuncture therapy in the earlier period.It is benefit to elevating the ability of antioxygen of focal cerebral ischemia of rats.

Objective To investigate and observe the expression of Peroxiredoxin Ⅵ in ischemia cortex of rats and the intervention effect of Xingnao Kaiqiao Acupuncture(XKA) therapy.Methods Through western blotting,we detected the expression of Peroxiredoxin Ⅵ in xingnao kaiqiao group,comparison group,model group and sham operation group in middle cerebral artery occlusion(MCAO)model of rats.Results At 6h,the expression of Peroxiredoxin Ⅵ in xingnao kaiqiao group,comparison group and sham operation group was increased than that in moddle group,of which Xingnao Kaiqiao group increased obviously(P

OBJECTIVE: Structural equation modeling was used to explore the relationship between mental health and social psychological factors. METHODS: Using multi-stage sampling method,1 200 first-line production workers working in enterprises were chosen as study subjects. Chinese version of the WHO-5 well-being Index,and Social Psychological Factors Questionnaire(a self-designed questionnaire based on job demands control model) were used to investigate the mental health and social psychological factors. The structural equation modeling of social psychological factors on mental health was constructed. RESULTS: Among the 1 200 workers,about 34. 8% workers had poor psychological well-being(the score of the WHO-5 well-being Index is equal or less than 13). Job demands and job autonomy were available and have direct effect on work-related pressure [standardized path coefficient(β) were 0. 162 and-0. 186,P < 0. 05]. Job demands,job autonomy and work-related pressure were available have direct effect on mental health(β were-0. 136,0. 235 and-0. 135,P < 0. 05). Job demands can have an indirect effect on mental health through work-related pressure(β =-0. 022,P < 0. 05),and job autonomy can have an indirect effect on mental health through work-related pressure(β = 0. 025,P < 0. 05). CONCLUSION: The results of mental health and social psychological factors are consistent with the job demand control model. Job demands and work-related pressure are risk factors and job autonomy is a protective factor for mental health. Mental health intervention should be taken according to the related factors.

OBJECTIVE: To analyze Th1 and Th2 immune balance related cytokines and clinical significance in obstructive sleep apnea hypopnea syndrome children without allergic rhinitis and asthma. METHOD: Collected 91 cases of obstructive sleep apnea hypopnea syndrome children with obstructive level data, and measured the serum Th1 cytokine TNF-beta and IFN-gamma, Th2 cytokines IL-4 and IL-5 levels. One hundred and five normal children were enrolled for the same detection of serum cytokines. RESULT: Non-allergic rhinitis and asthma children serum levels of IFN-gamma was lower than control group children, the difference was statistically significant (P < 0. 01). Other cytokines (TNF-beta, IL-4 and IL-5) were no significant difference with the control group. CONCLUSION Th1 and Th2 immune response was imbalance in non-allergic rhinitis and asthma obstructive sleep apnea hypopnea syndrome children. The decline in Th1 cell-mediated protective immune response cells may cause disease.
Asthma ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Interferon-gamma ; blood ; Interleukin-4 ; blood ; Interleukin-5 ; blood ; Lymphotoxin-alpha ; blood ; Male ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial ; Sleep Apnea, Obstructive ; blood ; Th1 Cells ; metabolism ; Th2 Cells ; metabolism

Objective:To investigate the independent risk factors for fever after endoscopic radiofrequency ablation (RFA).Methods:From January 2016 to April 2021, 51 patients with early esophageal cancer, who were treated with RFA in the Department of Gastroenterology, Changhai Hospital and whose lesion range exceeded 3/4 of the circumference of esophagus, were included in the case-control study. Patients were divided into fever group ( n=15) and non-fever group ( n=36) according to whether they had fever after operation. The general condition of patients, family history of gastrointestinal tumors, lesion length, lesion range, ablation energy and ablation times were mainly collected for univariate analysis. The variables with P<0.1 were further included in multivariate logistic regression analysis to explore the independent risk factors for fever after RFA. Results:Univariate analysis showed that the lesion length ( t=-3.89, P<0.001), lesion range ( χ2=11.52, P=0.001) and ablation energy ( P=0.001) were significantly different between the two groups. Pearson correlation showed that there was a significant positive correlation between lesion length and lesion circumference ( r=0.71, P<0.001), and the lesion range was determined by the lesion circumference length. Therefore, the two variables of lesion length and ablation energy were finally included in the logistic regression analysis. Logistic regression analysis showed that the risk of fever after RFA was 1.21 times as high as that before when the length of esophageal lesions increased by 1 centimeter (95% CI: 1.01-1.43, P=0.037). The risk of fever after RFA using 12 J ablation energy was 0.43 times as high as that using 10 J ablation energy (95% CI: 0.22-0.85, P=0.015). Conclusion:Lesion length and ablation energy are independent risk factors for fever after esophageal RFA. Patients with long segment early esophageal cancer and using low ablation energy are more likely to have fever after RFA.

Inflammatory bowel disease(IBD)is a chronic inflammatory disease of the gastrointestinal tract that includes Crohn's disease and ulcerative colitis.IBD may be caused by complex interactions between genetic susceptibility,environmental factors,and alterations in the gut microbiota,resulting in dysregulated innate and adaptive immune responses.Recent studies have identified macrophages in the intestinal inflammatory response as having the plasticity to not only regulate inflammation,but also to promote tissue repair and healing.As aberrant macrophage polarization occurs during the development of IBD,the balance between the phenotype and function of pro-inflammatory M1 and anti-inflammatory M2 macrophages is regulated by extracellular and intracellular stimuli,and this process is therefore expected to be a potential target for new therapeutic approaches.This article reviewed the progress of research on macrophage polarization in IBD.

Objective:To comprehensively evaluate the input and output efficiency of scientific research in hospital by bootstrap data envelopment analysis, to provide useful information for optimization of scientific performance appraisal and hospital discipline development strategy.Methods:37 disciplines were included as decision making unit, input variables include research expenditure and number of research personnel, and output variables include number of science and technology awards, research projects, patent transfer, paper, composition, and academic influence. The bootstrap-DEA method was used to evaluate the efficiency of all DMUs.Results:The main of overall efficiency and pure technical efficiency in basic DEA model are 0.858 and 0.909, but are 0.804 and 0.853 in Bootstrap DEA model, the differences between two models have statistically significant ( P<0.001). There are 11 DMUs with an overall efficiency in 0.9~1.0, 14 DMUs in 0.8~0.9, 7 DMUs in 0.6~0.8, 5 DMUs lower than 0.6. There are 3 DMUs are increasing return to scale, 16 DMUs are constant return to scale, 18 DMUs are decreasing return to scale. No statistically significance was observed between different types of DMUs( P>0.05). There are 4 DMUs reveal input slacks in number of research staffs and 10 DMUs reveal output slacks. Conclusions:The results of Bootstrap-DEA are more accurate than the basic methods for the evaluation of the input-output efficiency of hospital scientific research, so that it is worth popularizing and applying. According to the evaluation results, the hospital management department and disciplines could optimize their discipline development strategies and put forward targeted improvement measurements.

OBJECTIVETo investigate the current supply and use of personal protective equipment (PPE) among rural-to-urban migrant workers in small and medium enterprises (SMEs) in Zhongshan and Shenzhen, China and the influential factors for the use of PPE, and to provide a basis for better occupational health services and ensuring the health of migrant workers.

METHODSMulti-stage sampling was used to select 856 migrant workers from 27 SMEs in Zhongshan and Shenzhen, and face-to-face questionnaire survey was conducted in these subjects. Statistical analysis was performed by one-way analysis of variance, chi-square test, and logistic regression.

RESULTSOf all migrant workers, 38.67%were supplied with free PPE by the factory, and this rate varied across industries (furniture industry: 45.81%; electronic industry: 31.46%) and SMEs (medium enterprises: 42.13%; small enterprises: 39.20%; micro enterprises: 22.16%); 22.43% insisted on the use of PPE. The logistic regression analysis showed that factors associated with the use of PPE included sex, age, awareness of occupational health knowledge, and the size of enterprise.

CONCLUSIONThe rates of supply and use of PPE among migrant workers are low. The larger the enterprise, the better the supply of PPE. Male gender, being elder, and high occupational health knowledge score were favorable factors for the use of PPE, while small enterprise size was the unfavorable factor for the use of PPE.

Adult ; China ; Female ; Humans ; Male ; Occupational Health Services ; statistics & numerical data ; Protective Devices ; statistics & numerical data ; Rural Population ; statistics & numerical data ; Transients and Migrants ; statistics & numerical data