Objective:To investigate the correlation between the change in metabolic components of urine and the abnormal sapra syndrome by using a rat model of abnormal sapra syndrome.Methods:Multiple factors,such as dry environment,dry feed,and chronic electrical stimulation,were used to establish the abnormal sapra syndrome in Wistar rats by Uyghur medicine.The differences in metabolites were detected through the metabonomics method.Results:The urine of rats in abnormal sapra syndrome group showed significant high abundance metabolites as follows:Leucine,isoleucine,and glycoprotein.And that significant low abundance metabolites as follows:Glutamine,creatine,citric acid,and phenylalanine.Conclusion:The urine of rats with the abnormal sapra syndrome displays abnormal energy metabolism.It is likely that the dysfunctional metabolisms of three major nutrients might be the molecular basis for the abnormal sapra syndrome.

Objective To discuss the effects of personality features on psychological status of patients with lung cancer in perioperative period.Methods Choosing 97 patients from the thoracic department of the second Xiangya Hospital of Central South University as the study objects.The general information,psychological status and personality features were investigated by using the self-made General Information Questionnaire,Eysenck Personality Questionnaire( EPQ),Self-rating Depression Scale (SDS),Self-rating Anxiety Scale(SAS) and Self-rating Symptom Scale(SCL-90).Results The scores of seven factors including total scores( 153.28±41.98),somatization ( 1.78 ± 0.42 ),compulsion ( 1.96 ± 0.52 ),depression ( 1.77 ± 0.67 ),anxiety ( 1.82 ± 0.56 ),hostility ( 1.68 ± 0.87 ),panic ( 1.44 ± 0.75 ) and psychosis ( 1.56 ± 0.51 ) in SCL-90 were higher than domestic norm (P ＜ 0.05 ).The score of EPQ-P(Psychoticism) ( 10.96 ± 2.65 ) were higher than the domestic norm ( 5.84 ± 3.27 )(P＜0.001 ),and EPQ-N(neuroticism) and EPQ-P were positively correlated with the scores of seven factors in SCL-90.Conclusion The mental status of patients with lung cancer in perioperative period is poor.Solitude and uncaring others are the features of personality,which is correlated with psychological status,and EPQ-E (introvertion-extroversion) and EPQ-N can predict the happening of negative psychology.

ts The presence of +276G allele was significantly higher in the study group as compared with the control group.Conclusion Subjects with the +276G variant alleles may have a greater risk for weight gain after antipsychotic treatment.

A ZnO nanofibers carrier on the Pt electrode via electrospinning technology was prepared and then the Keggin phosphotungstic acid was deposited on the ZnO/Pt electrode using electrodeposition technology. The scanning electron microscopy showed that the zinc oxide fibers presented net structure and the diameter of its fiber was about 300 nanometers. The fourier transform infrared spectroscopy confirmed that the phosphotungstic acid adhered to the fiber surface. The electrochemical property of the modified electrode showed that it exhibited rapid response, excellent sensitivity and good stability, achieving rapid and accurate determination. The electrode responded linearly to ascorbic acid ( AA) in a concentration range from 8. 8 × 10-7 to 3. 3 × 10-4 mol/L with a low detection limit of 2. 5 × 10-7 mol/L. The method is promising for the development of AA detecting instrument.

Objective To investigate the related factors of central nervous system infection in patients who received invasive intracranial pressure monitoring.Methods The clinical data of 63 patients who received invasive intracranial pressure monitoring were retrospectively analyzed.Possible related factors including gender,age,disease,Glasgow coma scale score,emergency operation or selective operation,duration of the operation,drainage tube placement site,drainage tube lifetime,sensor insertion site,sensor indwelling duration,electrolytes,glucose and other complications were studied and compared retrospectively between patients with and without central nervous system infection.All data were analyzed with univariate analysis and multivariate Logistic regression analysis to identify the related factors and independent risk factors associated with central nervous system infection.Results In univariate analysis,drainage tube placement site (x2 =12.345,P =0.002),drainage tube lifetime ((2.5 ± 0.9) d and (6.3 ± 5.7) d in patients without and with central nervous system infection,respectively,t =-4.434,P =0.000),sensor insertion site (x2 =4.701,P =0.030),sensor indwelling duration ((6.5 ± 3.0) d and (8.9 ± 4.6) d in patients without and with central nervous system infection,respectively,t =-2.420,P =0.019) and other complications (x2 =13.086,P =0.000) were the relevant factors of central nervous system infection (P ＜0.05).In multivariate Logistic regression analysis,the sensor insertion site (OR =0.047,P =0.000) and other complications (OR =10.953,P =0.019) were the independent risk factors for the central nervous system infection.Conclusions There are a variety of factors related to central nervous system infection in patients with placement of intracranial pressure monitoring.The sensor insertion site and other complications were the independent risk factors for the central nervous system infection.

Objective To discuss the diagnostic value of distal subclavian artery flow velocity tracing for proximal segment severe stenosis.Methods 56 cases with 112 subclavian arteries were examed by ultrasonography and multidetector CT angiography respectively,then the flow velocity tracing of distal subclavian arteries had been compared with CT results.Results In all 112 subclavian arteries,there were 37without proximal segment stenosis,32 with mild stenosis,12 with moderate stenosis,and 31 with severe stenosis.Innominate arteries and other parts of subclavian arteries had no stenosis.In diagnosis of subclavian artery proximal severe stenosis using single phase single peak waveform,the sensitivity,specificity,positive likelihood ratio,and negative likelihood ratio were 83.9 ％,96.3 ％,22.7,0.063 respectively.The sensitivity,specificity,positive likelihood ratio,and negative likelihood ratio were 100 ％,93.8 ％,16.1,0 respectively,in terms of diagnosis by application of acceleration time ≥0.11s.Conclusions The statistics of acceleration time ≥0.11 s and single phase single peak waveform have high application value in diagnosis of subclavian artery severe stenosis respectively.

Objective To investigate the correlation between shear wave velocity and tissue fibrosis score in thyroid space-occupying lesions.Methods The shear wave velocity of 55 thyroid space-occupying lesions was examined by virtual touch tissue quantification.The shear wave velocity of different solid parts of the lesions was detected for several times and 15 data were genarated.Then maximum and minimum value were removed.The maximum (Vmax),minimum (Vmin),mean (Vm) of shear wave velocity were calculated with the rest of 13 data.Meantime the fibrosis degree of these pathological lesions were scored by using optical micorscope.The maximum (Fmax),minimum (Fmin) and mean (Fm) fibrosis degree were calculated with these scores.Then the difference between Fmax,Fmin and Fm value of benign lesions and malignant lesions was analyzed.The linear correlation between Fmax and Vmax,Fmin and Vmin,Fm and Vm was also analysed.Results In the 55 lesions,30 lesions were benign and the rest was malignant.The Fmax,Fmin,Fm of benign lesions were 1.38 ± 1.44,0.68 ± 0.25,0.91 ± 0.73 respectively; the corresponding value of malignant lesions were 5.00 ± 1.91,3.52 ± 1.82,4.08 ± 1.75 respectively.There was significant difference between the benign group and malignant group (t test,P ＜0.01).There were linear correlation between Fmax and Vmax,Fmin and Vmin,Fm and Vm and the Pearson correlation coefficients were 0.504,0.284,0.453 respectively.Conclusions The shear wave velocity and fibrosis degree of thyroid lesions has linear relationship.The heavier the degree of fibrosis is,the faster the shear wave velocity would be.

Objective To investigate the ameliorative effect and a mechanism of APS on the hepatic steatosis in diabetic KKAy mice.Methods KKAy and C57BL/6J mice were respectively seperated into KK and K+A(n=8)as well as C and C+A(n=10)groups.Blood and hepatic biochemical parameters were observed.Insulin sensitivity was analyzed by OGTT & HOMA-IR.Hepatic pathological changes were presented through microscope and TEM.The expressions of hepatic GSK3? and insulin-induced Ser9GSK3? were performed by Western blot.Results With 8-week APS therapy in K+A group,the levels of blood glucose and hepatic TG and FFA were decreased,insulin sensitivity was improved,the hepatic steatosis was significantly alleviated(P

AIM: To unveil the molecular mechanism of i sc hemic myocardium with displaying the differences on the protein expression in my ocardium. METHODS: Proteins of the ischemic myocardium induced by pituitri n were seperated by two dimentional electrophoresis (2-DE). The 2-DE image was a nalyzed by the software package PDQuest7.1.1. RESULTS: 10 proteins showed significant difference (P

目的观察MOTOmed智能运动训练系统对脑卒中偏瘫患者上肢运动功能和日常生活活动能力(ADL)的影响，并进行相关费用的分析和评价。方法将60 例脑卒中患者分为对照和治疗组各30 例，均采用常规康复治疗，治疗组在此基础上增加MOTOmed智能运动训练系统训练，并对每组患者在入组时、治疗2 个月和4 个月末分别采用简式Fugl-Meyer 评定法(FMA)、Barthel 指数(BI)对患者的上肢运动功能和ADL进行评定，并进行成本-效果分析。结果治疗后，治疗组FMA和BI 评分优于对照组(P<0.05)。两组患者住院总成本之间无显著性差异(P>0.05)，治疗组各项指标每改善1 分(或5 分)所产生的相关成本费用明显低于对照组(P<0.05)。治疗组与对照组比较，上肢运动功能评分每增加1 分，少花费56.3 元；ADL评分每提高5 分，少花费278.5 元。结论脑卒中偏瘫患者上肢运动功能康复治疗中，应用MOTOmed智能运动训练系统是一种既经济又有效的康复治疗方案。