Aiming at the unstable moral relationship between doctor and patient,the in-depth analysis and consideration were performed to factors influencing the harmonious relationship between doctor and patient,indicating that it was of great significance to the establishment of harmonious moral relationship between doctor and patient by taking the opportunity of new medical reform and making the best of antiseismic spirit.

Objectlive To explore the health effects of passive smoking on children. Methods During the period of March 1,2000-Feb. 28, 2001, the frequencies of respiratory diseases (eg. cold,chathitis,pneumonia and asthma)were investigated among 1031 4-6-year old children in 4 day-care nursing schools in Lanzhou, 485 children of which were selected for the determinations of the concentration of sulphocyanate,bacteriolytic enzyme and immunoglobulin (IgG, IgA, lgM)in saliva. Results The proportion of the numbers of children suffering from respiratory diseases and cold at least 4 times per year to all of 1031 children increased with the increase of intensity of passive smoking exposure (respiratory disease: X2=13,8, P

In the present study the projections were traced from the red nucleus and the region of the griseum centrale mesencephali to the inferior olivary complex (IOC) by using the method of anterograde transport of the WGA-HRP in the cat. The results has led to the following conclusions: 1.Both injected regions have positive projections to the ipsilateral IOC. No labeled cells were found in the IOC. 2. The projections from the red nucleus to the IOC terminated in the dorsal lamina of the principal olive and the dorsal end of the caudal half of the medial accessory olive. The projections from the region of the griseum centrale mesencephali to the IOC terminated in the whole medial accessory olive, ventral lamina of the principal olive and the connecting part between the ventrolateral end of ventral lamina and dorsal lamina of the principal olive. The most heavily labeled regions were the dorsal lamina of the principal olive among the regions receiving projection from the red nucleus and the medial accessory olive among those receiving fibers from the griseum centrale mesencephali region, the other regions were more lightly labeled.3. Some labeled regions of the IOC in the present study overlapped with those regions receiving fibers from the spinal cord reported by others. In the present study the labeled area is more extensive than those reported in the literature.

ts The presence of +276G allele was significantly higher in the study group as compared with the control group.Conclusion Subjects with the +276G variant alleles may have a greater risk for weight gain after antipsychotic treatment.

Objective To investigate the effects of different doses of oxycodone on postoperative pain and stress response in patients undergoing gynecological laparoscopic surgery. Methods Sixty patients scheduled for gynecological laparoscopy,aging from 18 to 50 years old,of ASA Ⅰ or Ⅱ,were included and randomized into three groups:control group (group C),low dose of oxycodone group (group L),high dose of oxycodone group (group H),20 cases in each group.Pa-tients in group L,H received 0.05,0.1 mg/kg oxycodone respectively while paitents in group C re-ceived saline 5 ml 1 5 min before the end of the surgery.Visual analogue scale(VAS)pain score and RASS score were measured on 1,6,12 and 24 h postoperatively.Glucose and serum cortisol were also measured before the operation and on time points of 6,12 and 24 h after the operation.Adverse effects were recorded too.Results Compared with group C,VAS were significantly lower in group L and H within 1 hour postoperatively.(P <0.05).VAS was significantly lower in group H than that in group C and L at 6 h postoperatively (P <0.05 ).The RASS scores of group L and H were significantly lower than those in group C (P <0.05)at 1 h postoperatively.Blood glucose and serum cortisol of group L and H increased at 6,12 and 24 h after operation (P <0.05).Compared with group C,blood glucose and serum cortisol were significantly lower in group L and group H at 6,12 h after operation (P <0.05).There was no significant difference in the incidence of adverse reactions in each group. Conclusion Oxycodone 0.1 mg/kg injected before the end of gynecological laparoscopic surgery could effectively relieve postoperative pain with less adverse reactions,and decrease postoperation stress re-sponse.

Histological classification system ( HCS) is an important system in judging and predicting ma-lignant behaviors of breast cancer .This study is aimed to analyze research progress and development direction of HCS by perusing literatures ,including the origin and development progress of HCS ,contents and deficiencies of Nottingham classification system(NCS),and introduction of novel classification system .HCS of breast cancer has a history of more than one hundred years ,among which NCS is the most widely used ,based on morphological fea-tures of cancer cells .However,there are still some shortcomings about NCS ,such as few indexes incorporation , great evaluation variation and low evaluation efficiency .Recently ,many newly evaluation systems have been devel-oped,including“nucleus+proliferation”classification system ,computer assisted classification system and compre-hensive prognostic classification model .Therefore,the future development directions of HCS on breast cancer is to use high throughput analysis technology to extract and analyze the hidden molecular information in cancer cells and the surrounding tumor microenvironment ,so as to better guide personalized therapy and predict clinical prog-nosis.

Objective To investigate the influence of passive smoking to pregnant woman's and fetus's health by the detection of biomarker. Methods A questionnaires about passive smoking made by ourselves were answered by 236 pregnant women including quantity and the number of year of smoking in the family and working places. At the same time pregnant woman's saliva, venous blood, urine and umbilical cord blood were collected. The sulphocyanate in their saliva was determined with pyridine-barbiturate method; the cotinine in venous blood, urine and umbilical cord blood were determined with barbiturate method. Results The content of sulphocyanate in saliva was different upon the quantity of passive smoking of pregnant women; there were significant differences had been seen among groups of passive smoking in cotinine in venous blood, urine and umbilical cord blood. Conclusion The contents of cotinine in venous blood, urine and umbilical cord blood are biomarkers of pregnant woman subjected to passive smoking, and passive smoking of pregnant woman will influence the health of pregnant woman and fetus.

AIM: To unveil the molecular mechanism of i sc hemic myocardium with displaying the differences on the protein expression in my ocardium. METHODS: Proteins of the ischemic myocardium induced by pituitri n were seperated by two dimentional electrophoresis (2-DE). The 2-DE image was a nalyzed by the software package PDQuest7.1.1. RESULTS: 10 proteins showed significant difference (P

Objective To study the effect of Toll-like receptor 4(TLR4)on the expression of IRF-3 and IFN-β during the inflammatory reaction induced by cerebral ischemia reperfusion in mice.Methods Totally 144 mice were randomly divided into 3 groups:(1)ischemia reperfusion group(I group):the mice were subjected to 12 minutes ischemia by bilateral common carotid arteries(CCA)occlusion,and reperfusion without additional intervention;(2)TLR4 blocking group(T group):after 10 minutes of bilateral CCA occlusion,TLR4 antibody was injected slowly into right CCA within 2 minutes;(3)sham group(S group):no CCA occlusion was performed.At 1,2,3 and 4 d after ischemia reperfusion,the expression levels of TLR4,IRF-3 and IFN-β protein in the cortex was respectively examined by Western blot.Results In the right cortex,the expression levels of TLR4,IRF-3 and IFN-β of I group were distinctly higher than that of S and T gtoup(P<0.05);the expression levels of the 3 protein of T group were significantly higher than those of S group(P<0.05).Conclusion The cerebral ischemia reperfusion could activate TLR4 expression in the cortex of the mice.TLR4 might participate in the cerebral ischemia reperfusion through upregulating the expression of IRF-3 and IFN-β.