Objective:To investigate the effects of dyslipidemia on early insulin secretion and insulin resistance in patients with type 2 diabetes mellitus(T2DM).Methods:93 newly diagnosed T2DM patients without lipid-lowering and anti-hyperglycemia therapies were divided into 3 groups by plasma lipids levels:normal lipids(group B),single high triglycerides(group C),and high triglycerides and high total cholesterol with or without low HDL-cholesterol or high LDL-cholesterol(group D).20 non-diabetic normal lipids subjects were healthy control group(group A).Early insulin secretion indexes(?I30/?G30)and insulin resistance indexes(HOMA-IR)taken from the oral glucose tolerance test were measured and analyzed.Results:Compared with healthy control subjects(group A),patients with T2DM(group B,C and D)had a significantly lower ?I30/?G30(P=0.0000,

BACKGROUNDTo explore the applicable value of transbronchial needle aspiration (TBNA) in the bronchial submucosa.

METHODSTBNA biopsy was performed in 76 cases of pulmonary diseases, which had no endoscopically visible pathologic change. The results of TBNA were compared with that of brushing for cytological examination.

RESULTSThe correct diagnosis of the pulmonary diseases was 85.5% (65/76) for TBNA and 55.3%(42/76) for brushing cytology, and the correct diagnosis of lung cancer was 78.0%(39/50) for TBNA, 38.0% (19/50) for brushing cytology. Slight bleeding at the penestrated site was observed in 52 patients and there were no other severe complications.

CONCLUSIONSTBNA is a safe, simple and effective method in clinical application and could be used widely.