TCM is unique and e ective on senile dementia in both theory and practice;therefore it is signi cant to generalize TCM understanding and experience on senile dementia for speci c therapy to reduce patients' cognition impairment and enhance their living quality.Sorting of TCM understanding on senile dementia pathogenesis and causes,it was clear that seniledementia was often seen in aging people characterized by de ciency in origin and excess in super ciality.Its de ciency in origin was de ciency of kidney essence,marrow and lucid yang failing to ascend.The origin aspect of senile dementia was believed to be the insu ciency of kidney.The de ciency of ve zang-organs was closely related to it.While the super ciality aspect was thought to be turbid phlegm and stagnant blood blocking brain and cerebral meridian with ve zang-organs all concerned.On one hand,the de ciency of kidney assisted by the de ciency of ve zang-organs could result in phlegm and blood stasis,that is to say excess resulted from de ciency.On the other hand,the stagnation of phlegm and blood stasis could block the generation,transformation and transportation of qi,blood and body uid,which would further consume the essence of the body.This is so-called de ciency transformed from excess.The above two aspects a ected each other and causing lingering pathogenic factors.

【Objective】   To explore the prescriptions related to the treatment of spleen and stomach diseases in Prescriptions of Peaceful Benevolent Dispensary (Tai Ping Hui Min He Ji Ju Fang,《太平惠民和剂局方》, TPHMHJJF), and investigate the medication and prescription rules. 【Methods】   The prescriptions of TPHMHJJF for treating spleen and stomach diseases were screened, and the data set was established by entering the prescriptions and standardized drug names using WPS Excel 2019. Herb frequency statistics, efficacy categorization, property, flavor, meridian tropism, association rules, cluster analysis, factor analysis, and complex network analysis were performed using Python 3.6.8 programming language and Gephi 0.9.2 visualization software. 【Results】   A total of 239 prescriptions were included after the screening, and the dosage forms were mainly pills and powders. The study involved 200 herbal medicines, among which 40 herbs had a frequency of ≥ 12. The herb with the highest frequency was Ganjiang (Zingiber Rhizoma). The herb properties were mainly warm in nature, with the most pungent herbs. Most herbs were attributed to the spleen and stomach meridians, and tonifying medicine were the main species. The association rule analysis identified 26 second-order association rules and 16 third-order association rules, with "Renshen (Ginseng Radix et Rhizoma) → Fuling (Poria)" as the leading rule in the former and "Fuling (Poria) + Baizhu (Atractylodis Macrocephalae Rhizome) → Renshen (Ginseng Radix et Rhizoma)" as the leading rule in the latter. Also, cluster analysis divided the top 30 herbs into six herb combinations that can warm the middle, move Qi, and dry dampness effectively. Factor analysis extracted 13 common factors, with Renshen (Ginseng Radix et Rhizoma), Fuling (Poria), and Baizhu (Atractylodis Macrocephalae Rhizome) as the highest contributing factors. Lastly, complex network analysis yielded the core prescription of 14 herbs, with Ganjiang (Zingiber Rhizoma), Renshen (Ginseng Radix et Rhizoma), Gancao (Glycyrrhizae Radix et Rhizome), and Chenpi (Citri Reticulatae Pericarpium) among the herbs with a higher weighting degree. 【Conclusion】  TPHMHJJF is mainly based on the use of warming herbs to treat spleen and stomach diseases, and its medication rule can be summarized into three aspects: (i) primarily using warming and tonifying to warm the middle and dissipate cold, (ii) using the method of moving Qi with aromatic nature to delight the spleen and appetize the stomach, and (iii) emphasizing the regulation of Qi and blood to calm the five zang-organs.