OBJECTIVETo research the regulating effects of different dosages of ginseng with hairy antler on the sexual dysfunction model of the gonad and the structure of shenyangxu male rats induced with adenine, and to look for the best compatible proportion of ginseng to hairy antler in the model.

METHODSHealthy male SD rats, 2 months of age and (220 +/- 20) g in weight, were randomly assigned to 13 groups: normal group, model group, ginseng group, hairy antler group and 9 different proportion groups of ginseng to hairy antler. Observations were made on the exterior syndrome, testosterone in sera, weight index of the prostate and seminal vesicle, and tissue changes of the testis in the experimental rat model.

RESULTSDosages of different proportions of ginseng to hairy antler had different improving effects on the exterior syndrome, testosterone in sera, weight index of the prostate and seminal vesicle, and tissue changes of the testis.

CONCLUSIONDifferent proportions of ginseng to hairy antler had different improving effects on the sexual dysfunction model of male rats induced with adenine, and the best compatible proportion of ginseng to hairy antler was 5 to 2, that is, 0.45 g ginseng to 0.18 g hairy antler or 0.90 g ginseng to 0.36 g hairy antler.

Adenine ; Animals ; Antlers ; Disease Models, Animal ; Male ; Medicine, Chinese Traditional ; Panax ; Rats ; Rats, Sprague-Dawley ; Sexual Dysfunctions, Psychological ; chemically induced ; drug therapy ; Testosterone ; blood