Pancreatic cancer (PC) is often asymptomatic in the early stage and most patients have progressed to the advance stage at the time of diagnosis.At present,chemotherapy is mainly used in patients with advanced PC,but PC patients have poor response to chemotherapy,which brings great challenges to the treatment of PC.Oxidative stress-induced reactive oxygen species (ROS) can cause damages in DNA,proteins,and lipids and produce the toxic and mutagenic metabolites that alter the biological behavior of tumor and transform the tumor into a malignant phenotype.Antioxidants have an antitumor effect and provide a basis for the design of anti-oxidative stress drugs for the treatment of PC.This article summarizes the research advances in the molecular pathways associated with oxidative stress and PC,in order to explore new ROS-targeted methods for the treatment of PC.