Objective To understand genomic copy number variations (CNVs) and ascertain karyotype for a 46,X0, + der(?) fetus, and investigate possibility and superiority of array-based comparative genomic hybridization (array-CGH ) in clinical cytogenetic diagnosis. Methods G-banded chromosome analysis was carried out. The whole genome of the fetus was scanned and analysed by array-CGH. The results of array-CGH were confirmed by RT-qPCR. Results G-banded chromosome analysis showed that the fetal karyotype was 46,X0, +der(?). Array-CGH revealed the derivative chromosome as Y chromosome without CNVs. A total number of 118 submicroscopic CNVs were identified. Comparable results between array-CGH and RT-qPCR were obtained for 9 novel CNVs. Conclusion Comparing with conventional cytogenetic analysis, array-CGH is of high resolution, high-throughput and high accuracy, which provides a technical platform for accurate detection of submicroscopic chromosomal aberrations.

OBJECTIVE：To invest igtae the rationality of drug use of pregnant women in the outpatient department of our hospital，and to promote rational drug use in the clinic. METHODS ：The prescriptions of pregnant women in Beijing Shijitan Hospital Affiliated to Capital Medical University from Jan. to Dec. in 2019 were extracted by using hospital information management system ，and then analyzed statistically in respects of drug varieties ，DDDs，safety grading ，and use of Chinese patent medicine. RESULTS ：The most frequently used drugs in obstetric outpatients were vitamins and microelements ，followed by blood system and hormone drugs. Grade B drugs with good safety were most used ，the use of ungraded drugs were reasonable ，and grade X drugs were not used. There were 6 kinds of Chinese patent medicines used for pregnant women ，of which 2 kinds were marked “usable”in the drug instructions ，4 kinds were not marked in the dug instructions ，and the Chinese patent medicines that were not marked“prohibited”and“cautious”in the drug instructions were not used. CONCLUSIONS ：The drug use of pregnant women are generally reasonable in outpatient department of our hospital. The safety of some Chinese patent medicine used during pregnancy still needs to be further confirmed.