Objective:To explore the application effect of humanistic care nursing model in patients with gynecological tumors.Methods:Using the convenient sampling method, a total of 136 gynecological tumor patients who were hospitalized in Henan Cancer Hospital from March 2020 to March 2021 were selected as the research objects. Patients were divided into the observation group and the control group using the random number table method, with 68 patients in each group. The control group received routine nursing intervention during hospitalization, while the observation group received humanistic care based on routine nursing. The intervention effect was compared using Symptom Checklist 90 (SCL-90) , Pittsburgh Sleep Quality Index (PSQI) and Nursing Satisfaction Questionnaire.Results:After intervention, the SCL-90 and PSQI scores of the observation group were lower than those of the control group, and the differences were statistically significant ( P<0.05) . After intervention, the scores of each item in the Nursing Satisfaction Questionnaire of the observation group were higher than those of the control group, and the differences were statistically significant ( P<0.01) . Conclusions:The application of humanistic care model in gynecological tumor patients can effectively improve their psychological status and sleep quality and increase patient satisfaction, which is worthy of clinical promotion.