AIM: To establish early normative rehabilitative procedure at acute stage for maximizing the restoration of injured neural function for the patients with stroke,letting them back to the social life and improving their quality of life.METHODS: Rehabilitative procedure including rehabilitative therapy,rehabilitative nursing,position management,active exercise,passive exercise,training of daily life activity and the management of incontinence.RESULTS: Early rehabilitation in acute stage can maximally restore the injured neural functions in the patients with stroke and reduce complications.CONCLUSION: Early rehabilitation for patients with stroke is helpful to the restoration of injured neural functions.

ObjectiveTo investigate the effect of comprehensive rehabilitation therapy on movement function of stroke patients.Methods121 cases of acute stroke were randomly divided into the rehabilitation group (n=59) and control group (n=62). Patients of the rehabilitation group were treated with Bobaths and motive relearning method. Cases of the control group were treated with ordinary rehabilitation. All patients were assessed by the clinical neural function-defect assessment, concise Fugl-Meyer assessment (FMA) and modified Barthel index (MBI).ResultsThe scores of the clinical neural function-defect assessment set, FMA, and MBI of two groups were not different before treatment (P>0.05), while there was a significant improvement after treatment (P<0.01), and scores of the rehabilitation group was significantly higher than that of the control group.ConclusionComprehensive rehabilitation therapy can facilitate the function recovery, and gain a good functional prognosis to the stroke patients.

As an active oxygen, ozone can induce oxidative stress, however, small doses of ozone pretreatment of the body may devel-op to oxidation toleration, even anti-oxidative damage, thereby protecting organ from ischemia-reperfusion injury. This paper reviewed the status of ozone pretreatment in organ ischemia-reperfusion, such as heart, kidney, liver, skeletal muscle, gonads and brain. Ozone therapy may have potential application values in organ transplants and cardiovascular diseases. Meanwhile, whether clinical application of ozone big autohemotherapy in ischemic cerebrovascular disease is reasonable or not in nearly 10 years was put forward.

Objective To explore the therapeutic effect of transcranial electrical stimulation (tDCS) on verbal dysfunction after stroke.Methods 86 patients with stroke aphasia were included in the study.They were divided into two groups according to the time of treatment and single and double numbers.43 patients in the control group received language rehabilitation training,43 cases in the observation group were given tDCS combined with language rehabilitation training.The clinical treatment effect was compared between the two groups.Results The effective rates of the observation group and the control group were 93.02％ and 62.79％ respectively,the difference between the two groups was statistically significant (χ2=7.667,P＜0.05).The language proficiency scores of the observation group and the control group were (176.60±13.23) and (144.62±10.29),respectively,which were significantly higher than pre-treatment (t=6.553,7.919,all P＜0.05),which of the observation group was superior to the control group,the difference between the two groups was statistically significant (t=6.830,P＜0.05).The CADL scores of the observation group and the control group were (85.86±6.87)points and (68.76±5.88)points,respectively,which were significantly higher than pre-treatment (t=6.879,8.472,all P＜0.05),which of the observation group was better than the control group,the difference was statistically significant (t=6.692,P＜0.05).ConclusiontDCS combined with language rehabilitation training can improve the verbal function of patients and improve their daily communication ability,which is beneficial to the rehabilitation of patients,and it is worth to learn.

Objective To explore any effect of proprioceptive neuromuscular facilitation (PNF) on the proprioception and balance of patients with knee osteoarthritis (KOA).Methods Forty patients with KOA were randomly divided into an experimental group (EG) and a control group (CG),each of 20.The PNF techniques of isotonic combined contraction,and rhythmic stable and dynamic reversal were applied in the EG,while the CG received quadriceps muscle strength training.Knee proprioception was evaluated using knee angle reconstruction experiments,and balance ability was measured using the one leg standing test (OLS) and the five times sit to stand test (FTSST).Results The errors in active and passive knee angle reconstruction at 30°,60° and 110° all improved significantly in the EG,but not in the CG.After the treatment,the OLS and FTSST results improved significantly in the EG,but only the OLS results improved significantly in the CG,not the FTSST times.Even so,the average OLS time in the EG was significantly longer than that of the CG after the training.Conclusion Proprioceptive neuromuscular facilitation can improve the proprioception and balance of persons with knee osteoarthritis.

BACKGROUND: Ischemic stroke has a younger tendency; hence to explore the risk factors of stroke in the middle-aged and youth for primary rehabilitation has extremely important clinical significance.OBJECTIVE: To investigate the risk factor-of stroke in the middle-aged and youth.DESIGN: A case-control analysis based on diagnose.SETTING: Department of neurology in a university hospital.PARTICIPANTS: Totally 100 hospitalized patients including the middle-aged and youth ( ＜ 44 years old, n = 63 ) and the pre-elderly (45 - 49years old, n = 37) with mean age of(42. 91 ±6.8) were selected into stroke group from the Department of Neurology, Xiangya Second Hospital, Central South University between July 1997 and December 2000. Another 100 surgical patients without history of cerebrovascular diseases aged(42.70 ± 2.98) including the middle-aged and youth( n = 61 ) and the pre-elderly( n = 39) were collected randomly from the same corresponding period as control gruop.METHODS: A comparative study of 12 risk factors between two groups was studied and compared the middle-aged group and youth, the pre-elderly group with control group.MAIN OUTCOME MEASURES: Morbidity comparison of each risk factor in each group.RESULTS: Hypertension, hyperlipemia, abnormal electrocardiogram (ECG),family history of stroke, arteriosclerosis of the eyeground, diabetes, and rheumatic heart disease are risk factors of ischemic stroke in the middle-aged.CONCLUSION: It is extremely important significance to reduce blood pressure and blood-fat level in the prevention of ischemic stroke.

Objective To investigate the effect of Ser473-Akt phosphorylation in the protection of atorvastatin to cerebral ischemia-re-perfusion (I/R) injury in rats. Methods Forty male Sprague-Dawley rats were randomly divided into normal group (n=10), sham group (n=10), I/R group (n=10) and intervention group (n=10). A model of cerebral ischemia-reperfusion in rats was establishied, with ischemia for 2 hours and reperfusion for 72 hours. The normal group and the sham group received no injury. I/R group was administered with normal saline only, and the intervention group received atorvastatin 10 mg/kg prepared with normal saline at palinesthesia, 24 and 48 hours after reperfu-sion. All rats were sacrificed 72 hours after reperfusion. HE staining and TUNEL staining were performed in the brain specimens. The ex-pression of Akt and Ser473-Akt in the prefrontal cortex of the brain were detected with Western blotting. Results Compared with I/R group, 72 hours after reperfusion, the damage of nerve cells significantly lessened in the intervention group;the apoptosis positive cells significant-ly reduced in the intervention group (t=-6.014, P<0.001). The expression of Ser473-Akt in prefrontal cortex was higher in I/R group than in the normal group and the sham group (t>20.327, P<0.001), and was higher in the intervention group than in I/R group (t=3.649, P=0.007). Conclusion The Ser473-Akt phosphorylation plays an important role in the protection of atorvastatin in nerve cell through anti-apoptosis of nerve cells, and reducing cerebral I/R injury.

Objective To explore the causes and risk factors affecting early death in patients with traumatic cervical spinal cord injury (SCI). Methods Clinical data of 553 patients with traumatic cervical SCI were analyzed retrospectively to discuss the related factors affecting early death of patients with traumatic cervical SCI by using univariate analysis and multivariate logistic regression analysis. Results The early mortality of the patients with traumatic cervical SCI was 4.0% ( 22/553 ). The main causes of the early death were respiratory failure in nine patients (40.9%) and electrolyte disorders in five (22.7%). Univariate analysis showed that age, cervical spinal cord injury severity, complications in respiratory, cardiovascular, digestive systems and electrolyte disturbance as well as tracheotomy were considered statistically significant for early death in patients with traumatic cervical SCI ( P < 0, 05 ). Multivariate logistic regression analysis showed that age, cervical SCI severity, complications in respiratory,cardiovascular system and electrolyte disturbance as well as tracheotomy. Conclusion Severe cervical SCI, combined respiratory, cardiovascular system and electrolyte disorder complications as well as tracheotomy are high risk factors for the early death in patients with traumatic cervical SCI.

ObjectiveTo investigate the characteristics of traumatic spinal cord injury (TSCI) urban inpatients of Tianjin in 2007. MethodsInpatients with TSCI of 8 hospitals in Tianjin in 2007 were reviewed. ResultsThere were 73 patients in total. Mean age was (51.34±14.597) years. Male∶Female was 3.56∶1. Falling, motor vehicle accidents （MVC） were the main causes of TSCI. The cervical spinal cord injuries were predominant. 26% were complete injury and 74% were incomplete. 6 cases were dead. Patients with ASIA grade D recover well. ConclusionFor the TSCI, the ages of patients increases and falling is the main cause.

Objective To discuss the clinical effect of transcranial magnetic stimulation in treatment of dysfunction and depression of parkinson disease patients. Methods A totao of 50 cases of parkinson patients were randomly divided into the observation group and the control group, each group 25 cases, the control group was given conventional medicine and rehabilitation training, the observation group was given low frequency repetitive transcranial magnetic stimulation based on the control group. Results After 1 months of treatment, UPDRS Ⅰ, UPDRS II, UPDRS III, UP-DRS total scores in the observation group were lower than that in the control group, there was statistical significance (P<0.05). Compared MMSE scores between the observation group and the control group, there was no statistical sig-nificance (P>0.05), but HAMD score in the observation group was lower than that in the control group, there was statis-tical significance (P<0.05). Conclusion Low frequency repetitive transcranial magnetic stimulation can be used as a non-invasive measure of physical therapy for parkinson's disease.