Objective: To explore the clinical characteristics of ST elevation and non-ST elevation acute myocardial infarction (AMI) related with left circumflex artery (LCX) occlusion. Methods: Clinical data of 86 consecutively enrolled patients with LCX occlusion -related AMI undergoing percutaneous coronary intervention (PCI) were retrospectively analyzed. According to manifestations of electrocardiography, the patients were divided into ST elevation myocardial infarction (STEMI) group (n=32) and non STEMI (NSTEMI) group (n=54). Clinical features and prognosis were compared between two groups. Results: Compared with NSTEMI group, there were significant increase in serum level of creatinine [(80±23) μmmol/L vs. (100±30) μmmol/L], in rates of intra-aortic balloon counterpulsation （IABP）support (3.7% vs. 18.8%), usage of invasive respiratory machine (1.9% vs. 15.6%), ischemic mitral reflux (13.0% vs. 40.6%), complete atrioventricular block (0 vs. 9.4%), proportion of left coronary artery dominant type (7.4% vs. 28.1%) and left ventricular end-diastolic diameter [LVEDd,（46±4）mm vs.（48±5）mm?]; And significant decrease in percentage of triple-vessel coronary disease (72.2% vs. 46.9%) in STEMI group, P<0.05 or <0.01. There was no significant difference in mortality rate during admission (3.1% vs. 0, P>0.05) between STEMI group and NSTEMI group. Conclusions: Compared with patients with NSTEMI, patients with STEMI have poorer heart function in patients with left circumflex artery occlusion, which may be related to more left coronary dominance.

This study was aimed to observe the effect ofpomegranate leaf tennis and Ananas coumosus leaf phenols on the growth of lactating mice through breast milk. Intragastric administration of different doses of drug was given to maternal mice. The general condition of newborn mice, body weight, tail length and organ coefficient of liver-related factors regulating the expression of lipid metabolism were observed. The results showed that both pomegranate leaf tennis and A. coumosus leaf phenols can obviously affect the growth and development of newborn mice through breast milk. And the effect of pomegranate leaf tennis was stronger than A. coumosus leaf phenols. Meanwhile, it obviously downregulated the expression of liver-related lipid metabolism enzymes in newborn mice. It was concluded that pomegranate leaf tennis and A. coumosus leaf phenols can affect the growth and development of newborn mice through breast milk. Its effect was related to the influence of lipid metabolism enzyme in the liver. Attention should be paid on taking this medication during lactation. Its clinical significance still required in-depth study.

Objective To evaluate the clinical efficacy and safety of domestic Sirolimus-eluting stents (Firebird) and imported Zotalimus-eluting stents ( Resolute) in the treatment of patients with unprotected left main coronary artery disease ( ULMCA) . Methods We retrospectively enrolled 76 patients with ULMCA treated by percutaneous coronary intervention (PCI) under the guidance of IVUS in our hospital. According to the different stents used in the procedure, the patients were divided into two groups: Domestic Sirolimus-Eluting Stents group (Firebird group, n = 42) and Imported Zotarolimus-Eluting Stents group (Resolute group, n = 34) . We analyzed the baseline characteristics, coronary artery lesion characteristics, stenting strategies and any changes in left ventricular ejection fraction ( LVEF) in both groups and investigated the long-term clinical outcomes. Results There were no significant differences in the baseline characteristics, the SYNTAX scores of the coronary artery lesion and the rate of complete revascularization between the two groups. Compared with that in Firebird group, there were more cases involving the distal left main (79. 4% vs. 45. 2% , P ﹤ 0. 05) and more patients using two stents strategies (29. 4% vs. 7. 1% , P ﹤ 0. 05) in the Resolute group. The change in LVEF post-PCI had no difference between the two groups. The patients were followed up for a mean of (23. 3 ± 10. 7) months. During the follow-up period, the occurrence of MACCE had no significant difference between the two groups. In the Firebird group, there were one sudden cardiac death, one nonfatal myocardial infarction, one stroke and five patients with recurrence of angina pectoris. In the Resolute group there were one sudden cardiac death, one target lesion revascularization and four patients with recurrence of angina pectoris. Conclusions Compared with the imported Zotalimus-Eluting Stents, the domestic Sirolimus-Eluting Stents are safe and effective in the treatment of patients with unprotected left main lesions under the guidance of IVUS. The two kinds of stent showed similar long-term clinical outcomes.

Objective To investigate the effect of improving the symptoms of Meniere's disease and quality of life of health education intervention. Methods From May 2012 to August 2013 in our hospital treated 87 cases of Meniere's disease were divided into intervention group (44 cases) and control group (43 cases), intervention group treated with Meniere's disease health education,vestibular symptom Index (VSI),dizziness handicap inventory (DHI),self-rating anxiety scale(SDS),self-rating depression scale(SAS)to improve the situation were compared. Results The intervention group after the intervention equilibrium,vertigo,dizziness,nausea,visual sensitivity,headache,and scores were signifi cantly lower than the control group(P<0.05). Intervention group after the intervention DHI emotional,functional,phys-ical sexual scores were significantly lower than the control group (P<0.05). After the intervention group SDS and SAS scores were significantly lower than the control group(P<0.05). Conclusion Meniere's disease has a significant impact on the vestibular function,psychological and quality of life of patients, health education helps to improve vestibular symptoms,reduce negative emotions,improve quality of life.

ObjectiveTo systematically review the psychological and behavioral health benefits and quality of life of adolescent participation in physical activity in a health-promoting school perspective, based on the International Classification of Functioning, Disability and Health (ICF) and PRISMA principles. MethodsPubMed, Web of Science, and CNKI were searched to collect randomized controlled trials related to adolescents' participation in physical activity in schools and health outcomes, published from January, 2011 to June 2023, for a systematic review. ResultsEight studies were included, with 23 652 participants from six countries, mainly from journals related to public health, nursing, child and adolescent mental health, and international environmental research. The types of school physical activity interventions included physical fitness (warm-up and stretching, recreation center activities, shuttle runs, jumping jacks and jump ropes, squats and push-ups, running, wrist and arm training), skills (dribbling, passing, throwing, and catching) and sports (Kripalu yoga, basketball, volleyball, soccer sports, Ringo alternative sports, tennis and jump rope). The frequency of activities was one to six times a week, the intensity ranged from low to high, and the duration was mainly from two to 40 weeks. The psychological and behavioral health benefits of school-based physical activity involved three aspects. In terms of mental health, their social-emotional competence improved, negative emotions reduced, self-efficacy increased, subjective emotional feelings, behavioral control and intelligence improved, cognition and mental health improved; the stress coping strategies were developed, and the cognitive structures for emotion regulation, positive thinking and stress coping were learned. In terms of behavioral health aspects related to physical activity, their physical health and physical activity levels increased, the sense of health responsibility and awareness increased, knowledge of nutrition and health was enriched, behavioral control improved, executive functioning improved, academic achievement and participation in school activities increased, and absence from duty decreased. In terms of quality of life, academic performance, exercise habits and healthy lifestyles, positive attitudes, and interpersonal and stress management skills all improved. ConclusionIn the health-promoting school perspective, physical activity is integrated into the school health promotion system, and physical activity interventions in fitness, skills and sports are implemented to improve adolescents' psychological and behavioral health and quality of life, namely improving cognitive and executive functioning; improving social skills, emotional control, positive thinking, positive physical activity behaviors and health literacy, positive mindset; improving academic performance, good health habits and positive attitude towards life, interpersonal and stress management skills; and increasing overall well-being.

Objective To systematically review the evidence from systematic reviews on the impact of physical activity on the men-tal and behavioral health of children and adolescents. Methods Literature was searched across databases including PubMed,Web of Science,Scopus,PsycINFO,Cochrane Li-brary,and CNKI for systematic reviews published between January,2014 and January,2024 regarding the effect of physical activity on the mental and behavioral health of children and adolescents.Relevant evidence was ana-lyzed. Results A total of ten English articles were included,involving 221 580 children and adolescents from Australia,China,Canada,the United States and Spain.The included studies were mainly from journals in the fields of pediatrics,child health and development,and psychology.Participants were aged five to 18 years and included both healthy individuals and those with health conditions such as neurodevelopmental disorders,depression and obesity.The interventions included school physical education programs,community physical activity projects,home exercise plans,extracurricular sports programs,extracurricular physical activities and interventions to reduce sedentary be-havior.Intervention types included aerobic exercise,strength training,and recreational activities.The frequency of interventions ranged from 15 to 120 minutes per session,two to six times per week,with intensities from low to high,lasting from six to 81 weeks.Health outcomes mainly reflected improvements in children's attention,ex-ecutive function,memory,and learning ability,reductions in anxiety and depressive symptoms,increases in self-esteem and self-efficacy,improvements in social adaptability and life satisfaction,reductions in obesity rates,and the promotion of healthier lifestyles. Conclusion Physical activity helps children and adolescents improve attention,executive function,memory and learning ability,reduce anxiety and depressive symptoms,boost self-esteem and self-efficacy,enhance social adaptability and life satisfaction,lower obesity rates,and promote positive lifestyle changes.

Objective: To explore the relationship between sleep quality and executive function among middle school students, so as to provide theoretical support for the promotion of adolescents physical and mental health development. Methods: From September to December 2023, 5 713 junior and senior high school students aged 13 to 18 were selected by stratified cluster random sampling method from Shanghai, Suzhou, Taiyuan, Wuyuan, Xingyi, and Urumqi. Pittsburgh Sleep Quality Index was used to conduct sleep quality survey. And conduct executive function was tested on middle school students, including inhibitory function, refresh function and conversion function tests. Spearman correlation and linear regression were used to analyze the relationship between sleep quality and executive function of middle school students. Results: The total Pittsburgh Sleep Quality Index (PSQI) score of boys was [4.0(2.0,6.0)] and that of girls was [5.0(3.0,6.0)], and the difference was statistically significant ( Z=-10.90, P < 0.01 ). The total PSQI score of boys was positively correlated with both 2-back reaction time and conversion function of executive function ( r =0.04, 0.04); the total PSQI score of girls was negatively correlated with 2-back reaction time ( r =-0.04) ( P <0.05). After controlling for variables such as mental health, physical activity and nutritional status,linear regression analyses showed that PSQI total score of middle school students was positively correlated with the inhibitory function and the conversion function response time [ B (95% CI )=1.28(0.21-2.34), 7.62(2.34-12.90), P <0.05]; the associations of total PSQI scores among middle school students with both 2-back and 1-back response time were not statistically significant [ B (95% CI )=-5.88(-16.14-4.37), 8.05( -3.39 -19.50), P >0.05]. Conclusion Positive correlations are observed on sleep quality with inhibitory and conversion functions of executive function among middle school students.

ObjectiveTo systematically study the global standards and implementation guidelines for health-promoting schools issued by the World Health Organization (WHO) and the United Nations Educational, Scientific and Cultural Organization (UNESCO) in 2021, explore the theories applying the components of WHO health services and construct the policy framework, content standards, and implementation path for integrating physical activity into the construction of health-promoting schools in primary and secondary schools. MethodsBased on the WHO health service system theory, a content analysis of WHO and UNESCO core policy documents in the fields of physical activity and health promotion in schools was conducted, including Making Every School a Health-Promoting School: Global Standards and Indicators; Making Every School a Health-Promoting School: Implementation Guidelines; and WHO Guidelines on School Health Services, to construct the policy framework, standard and implementation guideline framework, core content and implementation path for integrating physical activity into the construction of health-promoting schools in primary and secondary schools. ResultsThe content of the integration of health-promoting schools into the health service system could be constructed in six domains including leadership and governance, financing, service delivery, human resources, health technology and facilities, and health information systems. Implementing health services in the school environment to build health-promoting schools, the main tasks in six areas were refined into eight standards and 13 implementation areas. Integrating physical activity into health-promoting schools could be constructed from the six blocks of the health service system, including leadership and governance, financing for health-promoting schools, human resources for health-promoting schools, provision of school health services, technology and equipment, and health information. There are six implementation approaches in six blocks of health system: to strengthen the policy and governance capacity of integrating physical activity into health-promoting schools; to raise sufficient funds for the construction of physical activity integrated health-promoting schools; to integrate physical activity into the construction of health-promoting schools and provide comprehensive health care for teachers and students; to train human resources related to physical activity and health; to provide support for health technology and equipment and facilities for the construction of physical activity integration into health-promoting schools; and to establish a health-promoting school information system integrating physical activity and conduct related research. ConclusionPhysical activity is an important part of health services. Starting from the six components of health service, with the policy support of concept of health-promoting schools, this paper discussed the framework and content of integrating physical activity into health-promoting schools standards and implementation guidelines from the perspective of health services, and specific approaches to integrate physical activity into health-promoting school.

ObjectiveTo explore the policy framework, core content, and curriculum implementation of physical activity and health-related curriculum in perspective of health-promoting school. MethodsBased on the policies related to health-promoting school and the World Health Organization (WHO) theory of health service system, content analysis was conducted on the core policy documents of WHO and UNESCO, and to construct the policy framework, core contents, and implementation pathways of physical activity and health-related curriculum in schools from the perspective of health-promoting school. The core policy documents included Making Every School a Health-Promoting School: Global Standards and Indicators; Making Every School a Health-Promoting School: Implementation Guidelines; and WHO Guidelines on School Health Services. ResultsPolicy framework, theoretical basis, core content, and implementation pathways of physical activity and health-related curriculum were established in perspectives of WHO policies of health-promoting school. The core content of physical activity and health-related curriculum in health-promoting school context were systematically analyzed in terms of school physical activity and health-related curriculum. The specific implementation path of physical activity and health-related curriculum in health-promoting school involved six aspects: curriculum objectives, curriculum content, curriculum approaches, curriculum evaluation, learning materials, and teacher training. ConclusionHealth promotion is an important part of health service system. Health-related curriculum in schools is the use of educational and health-related tools to provide health services to students in a school context. Physical activity and health-related curriculum is a comprehensive health service for students' physical and mental health development in a health-promoting school setting. The pathways and methods for constructing a physical activity and health-related curriculum in a health-promoting school perspective involve six main areas: curriculum objectives, curriculum content, curriculum approaches, curriculum evaluation, learning materials, and teacher training.

Wound infection is becoming a considerable healthcare crisis due to the abuse of antibiotics and the substantial production of multidrug-resistant bacteria. Seawater immersion wounds usually become a mortal trouble because of the infection of Vibrio vulnificus. Bdellovibrio bacteriovorus, one kind of natural predatory bacteria, is recognized as a promising biological therapy against intractable bacteria. Here, we prepared a B. bacteriovorus-loaded polyvinyl alcohol/alginate hydrogel for the topical treatment of the seawater immersion wounds infected by V. vulnificus. The B. bacteriovorus-loaded hydrogel (BG) owned highly microporous structures with the mean pore size of 90 μm, improving the rapid release of B. bacteriovorus from BG when contacting the aqueous surroundings. BG showed high biosafety with no L929 cell toxicity or hemolysis. More importantly, BG exhibited excellent in vitro anti-V. vulnificus effect. The highly effective infected wound treatment effect of BG was evaluated on mouse models, revealing significant reduction of local V. vulnificus, accelerated wound contraction, and alleviated inflammation. Besides the high bacterial inhibition of BG, BG remarkably reduced inflammatory response, promoted collagen deposition, neovascularization and re-epithelization, contributing to wound healing. BG is a promising topical biological formulation against infected wounds.