Objective To investigate the safety and effectiveness of different nutrition support pathways after gastrectomy.Methods Clinical data of patients with gastric cancer received surgery treatment at our hospital from 2011 to 2013 were retrospectively analyzed.Patients were divided into 3 groups according to different nutrition support pathways,including group A (jejunostomy),group B (intraoperative nasal-bowel tube),and group C (parenteral nutrition).Results A total of 85 patients was retrospectively analyzed,including 28 in group A,26 in group B,and 31 in group C.The exhaust time had significant difference between groups A and B (t =2.312,P =0.02),and between groups A and C (t =3.323,P =0.005).The defecation had significant difference between groups A and B(t =4.211,P =0.001),and between groups B and C(t =3.402,P =0.004).There was significant difference in the adverse effect rate(x2 =6.611,P =0.037) and in hospital stays(P ＜0.01) among 3 groups.The hospitalization expense had significant difference between groups A and C (t =4.012,P =0.001),and between groups B and C (t =5.152,P =0.001).Conclusions Nutrition support via jejunostomy after gastrectomy was better than the other two pathways in the safety and effectiveness.